Gene info: ID 10911

Gene: UTS2

GENE ID: 10911

Synonyms: PRO1068|U-II|UCN2|UII

Description: urotensin 2

Gene type: protein-coding

Location: 1p36.23

dbXrefs: Ensembl:ENSG00000049247 MIM:604097 Vega:OTTHUMG00000001218 UniprotKB:O95399

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.251e-1 (AD) 5.616e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NTS	0.771
FOXB1	0.766
SIM1	0.761
LHX5	0.759
OTP	0.758
HMX2	0.757
DAPL1	0.744
C22orf42	0.743
SIX6	0.743
SOX14	0.739

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SHANK3	-0.401
LZTS1	-0.39
MGAT5B	-0.366
PITPNM2	-0.364
CRTC1	-0.364
TNRC18	-0.361
CYTH3	-0.36
DDN	-0.357
ICAM5	-0.354
ELFN2	-0.35

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UTS2 mRNA"	25510870
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UTS2 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UTS2 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UTS2 mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UTS2 mRNA"	25510870
D000082	Acetaminophen	Acetaminophen affects the expression of UTS2 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of UTS2 gene	27153756
D000638	Amiodarone	Amiodarone results in increased expression of UTS2 mRNA	19774075
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of UTS2 mRNA	16483693
D000968	Antimycin A	Antimycin A results in increased expression of UTS2 mRNA	19304788
D004958	Estradiol	Estradiol results in increased expression of UTS2 mRNA	19484750
C006780	bisphenol A	bisphenol A results in decreased expression of UTS2 mRNA	25181051
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of UTS2 mRNA	22079614
C018475	butyraldehyde	butyraldehyde results in increased expression of UTS2 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of UTS2 mRNA	23828170
C089595	cylindrospermopsin	cylindrospermopsin results in decreased expression of UTS2 mRNA	24921660
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of UTS2 mRNA	21056072
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of UTS2 protein	21056072
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in increased methylation of UTS2 promoter	27415467
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of UTS2 mRNA	20044591
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of UTS2 mRNA	23086925
D008727	Methotrexate	Methotrexate affects the expression of UTS2 mRNA	18502557
C119536	nickel acetate	nickel acetate affects the expression of UTS2 mRNA	23828170
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of UTS2 mRNA"	25510870
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of UTS2 mRNA	19710929
D059808	Polyphenols	Polyphenols results in decreased expression of UTS2 mRNA	16293270
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of UTS2 mRNA	24780913
D012402	Rotenone	Rotenone results in increased expression of UTS2 mRNA	19304788
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of UTS2 mRNA	23806026
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of UTS2 mRNA	21998131
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of UTS2 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005102	signaling receptor binding	-	TAS	10499587
GO:0005179	hormone activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006936	muscle contraction	-	TAS	10499587
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007268	chemical synaptic transmission	-	TAS	10499587
GO:0008217	regulation of blood pressure	-	IBA	21873635
GO:0008217	regulation of blood pressure	-	IEA	-
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0097746	regulation of blood vessel diameter	-	IBA	21873635
GO:0097746	regulation of blood vessel diameter	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	TAS	10499587

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
18338983	Increased plasma urotensin-II levels are associated with diabetic retinopathy and carotid atherosclerosis in Type 2 diabetes. (2008 Dec)	Suguro T	Clin Sci (Lond)