Gene: GADD45G

10912
CR6|DDIT2|GADD45gamma|GRP17
growth arrest and DNA damage inducible gamma
protein-coding
9q22.2
Ensembl:ENSG00000130222 MIM:604949 Vega:OTTHUMG00000020187 UniprotKB:O95257
NC_000009.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.051e-1 (AD)  4.791e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DHRS30.688
CEBPD0.657
DDIT40.64
MT2A0.63
SMOX0.628
MT1X0.62
SORBS30.613
EML30.612
GMNN0.609
PIEZO10.606

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR85-0.477
IGF1-0.437
PCDHAC1-0.395
TRPC5-0.394
HS6ST3-0.394
ADAMTS5-0.391
COL19A1-0.386
HAPLN1-0.381
SIAH3-0.379
GNRHR-0.377

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C47167410'(Z),13'(E),15'(E)-heptadecatrienylhydroquinone"10'(Z),13'(E),15'(E)-heptadecatrienylhydroquinone results in increased expression of GADD45G mRNA"23088786
C0700461,2-dioleoyloxy-3-(trimethylammonium)propane"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of GADD45G mRNA"22129739
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of GADD45G mRNA"28903501
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GADD45G mRNA"21354444
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of GADD45G mRNA28329830
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of GADD45G mRNA28329830
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GADD45G mRNA"25614096
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of GADD45G mRNA"21920950
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of GADD45G mRNA"20826375
C5736932-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in increased expression of GADD45G mRNA22193206
C0166172-nitropropane2-nitropropane results in increased expression of GADD45G mRNA19268524
C0166172-nitropropaneAPEX1 protein inhibits the reaction [2-nitropropane results in increased expression of GADD45G mRNA]19268524
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GADD45G mRNA"23196670
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of GADD45G mRNA21983209
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of GADD45G mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GADD45G mRNA"27188386
C0067574-biphenylamine4-biphenylamine results in increased expression of GADD45G mRNA24857880
C0944114-phenylcoumarin4-phenylcoumarin analog results in increased expression of GADD45G mRNA27773722
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole affects the expression of GADD45G mRNA"22745752
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GADD45G mRNA"27188386
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of GADD45G mRNA"19936915
D000082AcetaminophenAcetaminophen affects the expression of GADD45G mRNA15606129|1756273
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of GADD45G mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GADD45G mRNA]17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [xanthatin results in increased expression of GADD45G mRNA]23313378
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[xanthatin results in increased expression of GADD45G mRNA] which results in increased abundance of Reactive Oxygen Species]23313378
D000111AcetylcysteineAcetylcysteine inhibits the reaction [xanthatin results in increased expression of GADD45G protein]23313378
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GADD45G mRNA22129741
D020106AcrylamideAcrylamide results in increased expression of GADD45G mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GADD45G mRNA22100608
D000447AldehydesAldehydes results in increased expression of GADD45G mRNA25014914
D000638AmiodaroneAmiodarone results in increased expression of GADD45G mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GADD45G mRNA16483693
C050510arsenic trichloridearsenic trichloride results in increased expression of GADD45G mRNA16283526
C050510arsenic trichlorideIKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45G mRNA]16283526
D001280AtrazineAtrazine results in decreased expression of GADD45G mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of GADD45G mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of GADD45G mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GADD45G mRNA21569818
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of GADD45G mRNA25566086
D004958EstradiolEstradiol affects the expression of GADD45G mRNA22574217
D004958EstradiolEstradiol results in increased expression of GADD45G mRNA19484750
D004958EstradiolEstradiol affects the expression of GADD45G mRNA15598610
D004958EstradiolEstradiol results in increased expression of GADD45G mRNA19484750|2082637
C006780bisphenol Abisphenol A affects the expression of GADD45G mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of GADD45G mRNA20826375
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of GADD45G promoter23359474
C006780bisphenol Abisphenol A results in increased expression of GADD45G mRNA25181051
D000069286BortezomibBortezomib results in increased expression of GADD45G mRNA17898295
C546611brevetoxin 2brevetoxin 2 results in increased expression of GADD45G mRNA20498034
D002065BuspironeBuspirone results in decreased expression of GADD45G mRNA24136188
C018475butyraldehydebutyraldehyde results in increased expression of GADD45G mRNA26079696
D002104CadmiumCadmium affects the expression of GADD45G mRNA22562489
D002104Cadmium[Cadmium co-treated with Copper co-treated with Mercury] results in increased expression of GADD45G mRNA23355883
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GADD45G mRNA12160620
D019256Cadmium ChlorideCadmium Chloride affects the expression of GADD45G mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of GADD45G promoter22457795
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GADD45G mRNA19010381
D002166CamptothecinCamptothecin results in increased expression of GADD45G mRNA24792648
D002220CarbamazepineCarbamazepine affects the expression of GADD45G mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of GADD45G mRNA27339419
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of GADD45G mRNA19395590
D002737ChloropreneChloroprene results in increased expression of GADD45G mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in decreased expression of GADD45G mRNA20350560
D002784Cholesterol"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of GADD45G mRNA"22129739
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GADD45G gene20938992
C039671ciglitazoneciglitazone results in increased expression of GADD45G mRNA22193206
D002922CiguatoxinsCiguatoxins affects the expression of GADD45G mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of GADD45G mRNA16081524
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of GADD45G mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of GADD45G mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GADD45G mRNA]17585979
D002994ClofibrateClofibrate results in decreased expression of GADD45G mRNA22008536
D060729Coal AshCoal Ash results in increased expression of GADD45G mRNA19000753
C018021cobaltous chloridecobaltous chloride results in decreased expression of GADD45G mRNA21139344
D003078ColchicineColchicine results in increased expression of GADD45G mRNA20624997
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of GADD45G mRNA20971185
D003300Copper[Cadmium co-treated with Copper co-treated with Mercury] results in increased expression of GADD45G mRNA23355883
D019327Copper SulfateCopper Sulfate results in increased expression of GADD45G mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of GADD45G mRNA22077320
C030973cupric oxidecupric oxide results in increased expression of GADD45G protein22077320
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of GADD45G mRNA17383702
D016572CyclosporineCyclosporine results in increased expression of GADD45G mRNA20106945|2798913
D016572CyclosporineCyclosporine results in decreased expression of GADD45G mRNA19770486
D015255IdarubicinDexrazoxane inhibits the reaction [Idarubicin results in increased expression of GADD45G mRNA]28973540
D015255IdarubicinIdarubicin results in increased expression of GADD45G mRNA28973540
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GADD45G mRNA16054899
D003907Dexamethasone[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GADD45G mRNA]16054899
D003907DexamethasoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GADD45G mRNA]16054899
D064730DexrazoxaneDexrazoxane inhibits the reaction [Idarubicin results in increased expression of GADD45G mRNA]28973540
D003976DiazinonDiazinon affects the expression of GADD45G mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GADD45G mRNA21266533
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of GADD45G promoter23359474
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GADD45G mRNA21266533
D002945CisplatinCisplatin results in decreased expression of GADD45G mRNA22023808
D004008DiclofenacDiclofenac results in increased expression of GADD45G mRNA26934552
D004026DieldrinDieldrin affects the expression of GADD45G mRNA22546817
D004041Dietary FatsDietary Fats results in decreased expression of GADD45G mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of GADD45G mRNA26219507|2706063
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of GADD45G promoter23359474
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GADD45G mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of GADD45G mRNA]17942915
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GADD45G mRNA22129741
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of GADD45G mRNA21658437
D002117CalcitriolCalcitriol promotes the reaction [Testosterone results in increased expression of GADD45G mRNA]21592394
D002117CalcitriolCalcitriol results in increased expression of GADD45G mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of GADD45G mRNA21592394
D002117CalcitriolTestosterone promotes the reaction [Calcitriol results in increased expression of GADD45G mRNA]21592394
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of GADD45G mRNA22193206
D004317DoxorubicinDoxorubicin promotes the reaction [NR1I3 protein results in increased expression of GADD45G mRNA]21557330
D004317DoxorubicinDoxorubicin results in increased expression of GADD45G mRNA16404146
D000431EthanolEthanol results in decreased expression of GADD45G mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GADD45G mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GADD45G mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GADD45G mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GADD45G mRNA16174780|1735126
D005031EthylenethioureaEthylenethiourea results in increased expression of GADD45G mRNA18801409
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of GADD45G mRNA28329830
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of GADD45G mRNA28329830
C007738fluoranthenefluoranthene results in decreased expression of GADD45G mRNA28329830
D005472FluorouracilFluorouracil results in increased expression of GADD45G mRNA19272435
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GADD45G gene20938992
D004397FonofosFonofos results in increased methylation of GADD45G promoter22847954
C039281furanfuran results in decreased expression of GADD45G mRNA26194646
C419708gefitinibgefitinib results in decreased expression of GADD45G mRNA16685379
D019833GenisteinGenistein results in increased expression of GADD45G mRNA23019147
D019833GenisteinGenistein results in increased expression of GADD45G mRNA24967385
D005947GlucoseGlucose results in increased expression of GADD45G mRNA17178593
C004312glycidolglycidol results in decreased expression of GADD45G mRNA24915197
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of GADD45G mRNA19376150
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GADD45G mRNA22129741
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GADD45G mRNA25613284
C051890irinotecanirinotecan results in increased expression of GADD45G mRNA20097248
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GADD45G mRNA16054899
D0150561-Methyl-3-isobutylxanthine[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GADD45G mRNA]16054899
D0150561-Methyl-3-isobutylxanthineTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GADD45G mRNA]16054899
D007545IsoproterenolIsoproterenol results in increased expression of GADD45G mRNA21823215
D007608Kainic AcidKainic Acid results in decreased expression of GADD45G mRNA17997037
C533894LG 100815LG 100815 results in increased expression of GADD45G mRNA16951191
D008628Mercury[Cadmium co-treated with Copper co-treated with Mercury] results in increased expression of GADD45G mRNA23355883
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of GADD45G mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of GADD45G mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GADD45G gene20938992
D008727MethotrexateMethotrexate results in increased expression of GADD45G mRNA21678067
D008731MethoxychlorMethoxychlor affects the expression of GADD45G mRNA20829426
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GADD45G mRNA23458150
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GADD45G mRNA28001369
C030957methylmercury IImethylmercury II results in increased expression of GADD45G mRNA17905399
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of GADD45G mRNA24810058
C005246myristicinmyristicin results in decreased expression of GADD45G mRNA24792648
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of GADD45G mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GADD45G mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GADD45G mRNA"25554681|2562005
C017096n-butoxyethanoln-butoxyethanol results in increased expression of GADD45G mRNA19812364
D009532NickelNickel results in decreased expression of GADD45G mRNA24084258
C022838nickel chloridenickel chloride affects the expression of GADD45G mRNA22546817
C028007nickel monoxidenickel monoxide results in increased expression of GADD45G mRNA19167457
D009534NiclosamideNiclosamide results in increased expression of GADD45G mRNA26452273
C012655nimesulidenimesulide results in decreased expression of GADD45G mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of GADD45G mRNA20971185
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of GADD45G mRNA"16951191
D000069463Olive OilOlive Oil analog affects the expression of GADD45G mRNA17349074
D009966OrphenadrineOrphenadrine affects the expression of GADD45G mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of GADD45G mRNA25729387
D010126OzoneOzone results in increased expression of GADD45G mRNA19555225
D000073878Palm OilPalm Oil results in decreased expression of GADD45G mRNA18042831
C496932panobinostatGADD45G protein affects the susceptibility to [SRT2183 co-treated with panobinostat]23681230
C496932panobinostatpanobinostat inhibits the reaction [STAT3 protein binds to GADD45G promoter]23681230
C496932panobinostatpanobinostat promotes the reaction [resveratrol inhibits the reaction [STAT3 protein binds to GADD45G promoter]]23681230
C496932panobinostatpanobinostat promotes the reaction [resveratrol results in increased expression of GADD45G mRNA]23681230
C496932panobinostatpanobinostat promotes the reaction [SRT2183 inhibits the reaction [STAT3 protein binds to GADD45G promoter]]23681230
C496932panobinostatpanobinostat promotes the reaction [SRT2183 results in increased expression of GADD45G mRNA]23681230
C496932panobinostatpanobinostat results in increased expression of GADD45G mRNA23681230
C496932panobinostatresveratrol promotes the reaction [panobinostat results in increased expression of GADD45G mRNA]23681230
C496932panobinostatSRT2183 promotes the reaction [panobinostat results in increased expression of GADD45G mRNA]23681230
D010269ParaquatParaquat results in increased expression of GADD45G mRNA12595580|1524699
D010278ParathionParathion results in increased methylation of GADD45G promoter22847954
C046012pentanalpentanal results in increased expression of GADD45G mRNA26079696
C494474perchlorateperchlorate results in increased expression of GADD45G mRNA18801409
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of GADD45G mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of GADD45G mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of GADD45G mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of GADD45G mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of GADD45G mRNA22008536
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GADD45G mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of GADD45G mRNA26272509
D010705PhosgenePhosgene affects the expression of GADD45G mRNA16300373
C030090phosphoramide mustardphosphoramide mustard results in increased expression of GADD45G mRNA26708502
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of GADD45G mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of GADD45G mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of GADD45G mRNA16985257|1830175
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of GADD45G mRNA]20059764
D010938Plant OilsPlant Oils results in increased expression of GADD45G mRNA23370395
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GADD45G mRNA28903501
D011374ProgesteroneProgesterone affects the expression of GADD45G mRNA17251523
C005556propionaldehydepropionaldehyde results in increased expression of GADD45G mRNA26079696
C513428pyrachlostrobinpyrachlostrobin results in increased expression of GADD45G mRNA27029645
D017382Reactive Oxygen SpeciesAcetylcysteine inhibits the reaction [[xanthatin results in increased expression of GADD45G mRNA] which results in increased abundance of Reactive Oxygen Species]23313378
D017382Reactive Oxygen Species[xanthatin results in increased expression of GADD45G mRNA] which results in increased abundance of Reactive Oxygen Species23313378
C059514resveratrolpanobinostat promotes the reaction [resveratrol inhibits the reaction [STAT3 protein binds to GADD45G promoter]]23681230
C059514resveratrolpanobinostat promotes the reaction [resveratrol results in increased expression of GADD45G mRNA]23681230
C059514resveratrolresveratrol inhibits the reaction [STAT3 protein binds to GADD45G promoter]23681230
C059514resveratrolresveratrol promotes the reaction [panobinostat results in increased expression of GADD45G mRNA]23681230
C059514resveratrolresveratrol results in increased expression of GADD45G mRNA23681230
D012312RitodrineRitodrine results in decreased expression of GADD45G mRNA23370008
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GADD45G mRNA16054899
C089730rosiglitazone[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GADD45G mRNA]16054899
C089730rosiglitazoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GADD45G mRNA]16054899
D012402RotenoneRotenone results in decreased expression of GADD45G mRNA19013527
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of GADD45G mRNA"16678137
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of GADD45G mRNA21427059
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of GADD45G mRNA19564919
D012822Silicon DioxideSilicon Dioxide results in increased expression of GADD45G mRNA25351596
C009277sodium arsenatesodium arsenate results in increased expression of GADD45G mRNA23922661
C009277sodium arsenatesodium arsenate results in decreased expression of GADD45G mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of GADD45G mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of GADD45G mRNA26535918
C017947sodium arsenitesodium arsenite results in decreased expression of GADD45G mRNA16014739
C016104sodium bichromatesodium bichromate results in decreased expression of GADD45G mRNA25993096
C016104sodium bichromatesodium bichromate results in increased expression of GADD45G mRNA22561333
D012999SomanSoman results in increased expression of GADD45G mRNA19281266
D053260SootSoot results in increased expression of GADD45G mRNA22461453|2655175
C471405sorafenibGADD45G mutant form results in decreased susceptibility to sorafenib26172295
C471405sorafenibsorafenib promotes the reaction [CEBPD protein binds to GADD45G promoter]26172295
C471405sorafenibsorafenib results in increased expression of GADD45G mRNA26172295
C471405sorafenibsorafenib results in increased expression of GADD45G protein26172295
C525423SRT2183GADD45G protein affects the susceptibility to SRT218323681230
C525423SRT2183GADD45G protein affects the susceptibility to [SRT2183 co-treated with panobinostat]23681230
C525423SRT2183panobinostat promotes the reaction [SRT2183 inhibits the reaction [STAT3 protein binds to GADD45G promoter]]23681230
C525423SRT2183panobinostat promotes the reaction [SRT2183 results in increased expression of GADD45G mRNA]23681230
C525423SRT2183SRT2183 inhibits the reaction [RELA protein modified form binds to GADD45G promoter]23681230
C525423SRT2183SRT2183 inhibits the reaction [STAT3 protein modified form binds to GADD45G promoter]23681230
C525423SRT2183SRT2183 promotes the reaction [panobinostat results in increased expression of GADD45G mRNA]23681230
C525423SRT2183SRT2183 results in increased expression of GADD45G mRNA23681230
D013605T-2 ToxinT-2 Toxin results in increased expression of GADD45G mRNA26141394
D013629TamoxifenTamoxifen affects the expression of GADD45G mRNA17555576|2093736
C012568terbufosterbufos results in increased methylation of GADD45G promoter22847954
D013739TestosteroneCalcitriol promotes the reaction [Testosterone results in increased expression of GADD45G mRNA]21592394
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of GADD45G mRNA21592394
D013739TestosteroneTestosterone promotes the reaction [Calcitriol results in increased expression of GADD45G mRNA]21592394
D013739TestosteroneTestosterone results in increased expression of GADD45G mRNA21592394
D013739TestosteroneTestosterone affects the expression of GADD45G mRNA20403060
D013739TestosteroneTestosterone results in increased expression of GADD45G mRNA21669218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GADD45G mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GADD45G mRNA21570461|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GADD45G mRNA]16054899
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with EGF protein] results in decreased expression of GADD45G mRNA16054899
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GADD45G mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of GADD45G mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of GADD45G mRNA]16054899
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GADD45G promoter]21889950
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GADD45G mRNA16054899
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GADD45G mRNA25613284
D013849ThimerosalThimerosal results in increased expression of GADD45G mRNA16870260
D013853ThioacetamideThioacetamide results in decreased expression of GADD45G mRNA23411599
C523062thio-dimethylarsinatethio-dimethylarsinate results in decreased expression of GADD45G mRNA27320638
C009495titanium dioxidetitanium dioxide results in increased expression of GADD45G mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of GADD45G mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of GADD45G mRNA25729387
D019772TopotecanTopotecan results in increased expression of GADD45G mRNA25729387
D014212TretinoinTretinoin results in decreased expression of GADD45G mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of GADD45G mRNA15901671
C001899triptolidetriptolide results in decreased expression of GADD45G mRNA23639586
C080163trovafloxacintrovafloxacin results in decreased expression of GADD45G mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of GADD45G mRNA24383497
D014635Valproic AcidValproic Acid results in increased expression of GADD45G mRNA23179753
D014635Valproic AcidValproic Acid results in decreased expression of GADD45G mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of GADD45G mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of GADD45G mRNA19165385
D014747VinblastineVinblastine results in increased expression of GADD45G mRNA20624997
C025643vinclozolinvinclozolin results in increased expression of GADD45G mRNA23555832
D014750VincristineVincristine results in increased expression of GADD45G mRNA20624997
C029297vinylidene chloridevinylidene chloride results in decreased expression of GADD45G mRNA26682919
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of GADD45G mRNA"24525044
C022186xanthatinAcetylcysteine inhibits the reaction [xanthatin results in increased expression of GADD45G mRNA]23313378
C022186xanthatinAcetylcysteine inhibits the reaction [[xanthatin results in increased expression of GADD45G mRNA] which results in increased abundance of Reactive Oxygen Species]23313378
C022186xanthatinAcetylcysteine inhibits the reaction [xanthatin results in increased expression of GADD45G protein]23313378
C022186xanthatin[xanthatin results in decreased expression of TOP2A] which results in increased expression of GADD45G mRNA23824011
C022186xanthatinxanthatin results in increased expression of GADD45G mRNA21568272|2331337
C022186xanthatin[xanthatin results in increased expression of GADD45G mRNA] which results in increased abundance of Reactive Oxygen Species23313378
C022186xanthatinxanthatin results in increased expression of GADD45G protein23313378
C088658zoledronic acidzoledronic acid results in increased expression of GADD45G mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12716909  15383276  16189514  21900206  21988832  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0000185activation of MAPKKK activity-IBA21873635  
GO:0000185activation of MAPKKK activity-IDA9827804  
GO:0006915apoptotic process-IEA-  
GO:0006950response to stress-IEA-  
GO:0007275multicellular organism development-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0043065positive regulation of apoptotic process-IDA9827804  
GO:0046330positive regulation of JNK cascade-IDA9827804  
GO:0051726regulation of cell cycle-IBA21873635  
GO:1900745positive regulation of p38MAPK cascade-IDA9827804  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA9827804  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA9827804  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04110Cell cycle
hsa04115p53 signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23512105Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (2013 Jul)Beaty THHum Genet