Gene: SUB1

10923
P15|PC4|p14
SUB1 homolog, transcriptional regulator
protein-coding
5p13.3
Ensembl:ENSG00000113387 MIM:600503 Vega:OTTHUMG00000131071 UniprotKB:P53999
NC_000005.10
SNP Mapped
0   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.621e-1 (AD)  3.232e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB2A0.972
ACP10.966
SCOC0.965
MPC20.962
UBE2N0.961
MEAF60.959
YWHAZ0.959
UBE2V20.959
NDUFA50.956
VPS290.955

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.682
OR4F29-0.644
CSAG1-0.411
MAGEA12-0.376
MTRNR2L10-0.359
MTRNR2L6-0.346
RUNX3-0.343
EVC2-0.341
CXCR2-0.339
MTRNR2L9-0.336

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SUB1 mRNA"15215175
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of SUB1 mRNA"20206263
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SUB1 mRNA12958071
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SUB1 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of SUB1 mRNA20458559
D001280AtrazineAtrazine results in decreased expression of SUB1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SUB1 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SUB1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SUB1 mRNA"26238291
C044887beta-methylcholinebeta-methylcholine affects the expression of SUB1 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SUB1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of SUB1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SUB1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of SUB1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased phosphorylation of SUB1 protein22174045
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SUB1 protein24527689
C099555CD 437CD 437 results in increased expression of SUB1 mRNA12958071
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SUB1 mRNA20971185
D016572CyclosporineCyclosporine results in decreased expression of SUB1 mRNA25562108|2798913
D013759DronabinolDronabinol results in decreased expression of SUB1 mRNA18454173
D003703DemecolcineDemecolcine results in decreased expression of SUB1 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SUB1 mRNA28628672
C000944dicrotophosdicrotophos results in decreased expression of SUB1 mRNA28302478
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of SUB1 mRNA16931933
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of SUB1 mRNA27638505
D004147DioxinsDioxins affects the expression of SUB1 mRNA20463971
D000431EthanolEthanol results in decreased expression of SUB1 mRNA28986285
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SUB1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SUB1 mRNA17557909
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SUB1 mRNA23649840
C082360fipronilfipronil results in decreased expression of SUB1 mRNA23962444
D005557FormaldehydeFormaldehyde results in decreased expression of SUB1 mRNA23649840
D005839GentamicinsGentamicins results in increased expression of SUB1 mRNA22061828
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of SUB1 mRNA22634610
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SUB1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SUB1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SUB1 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of SUB1 mRNA27392435
C410337K 7174K 7174 results in decreased expression of SUB1 mRNA24086573
D008628MercuryMercury results in decreased expression of SUB1 mRNA19937285
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SUB1 protein25809596
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SUB1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SUB1 mRNA23649840
D016685MitomycinMitomycin results in increased expression of SUB1 mRNA12760830
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SUB1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SUB1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SUB1 mRNA"25554681
D009538NicotineNicotine results in increased expression of SUB1 mRNA17456735
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of SUB1 mRNA17616710
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SUB1 mRNA20971185
D017239PaclitaxelPaclitaxel results in decreased expression of SUB1 protein15907983
D011794QuercetinQuercetin results in increased expression of SUB1 mRNA15309432
C017947sodium arsenitesodium arsenite affects the methylation of SUB1 gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SUB1 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SUB1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SUB1 mRNA25613284
C012589trichostatin Atrichostatin A results in increased expression of SUB1 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SUB1 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of SUB1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of SUB1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SUB1 mRNA23179753
C111237vorinostatvorinostat results in increased expression of SUB1 mRNA27188386
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of SUB1 mRNA16931933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding-IEA-  
GO:0003697single-stranded DNA binding-IDA8062391  
GO:0003713transcription coactivator activity-IBA21873635  
GO:0003713transcription coactivator activity-IDA8062391  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI7809103  9847329  10887206  11389848  22113938  
GO:0042802identical protein binding-IPI16415882  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IDA8062391  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0060261positive regulation of transcription initiation from RNA polymerase II promoter-IBA21873635  
GO:0060395SMAD protein signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005667transcription factor complex-IBA21873635  
GO:0005667transcription factor complex-IDA8062391  
GO:0005730nucleolus-IDA-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal