Gene: STARD3

10948
CAB1|MLN64|es64
StAR related lipid transfer domain containing 3
protein-coding
17q12
Ensembl:ENSG00000131748 MIM:607048 Vega:OTTHUMG00000133213 UniprotKB:Q14849
NC_000017.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.091e-1 (AD)  7.476e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WDR590.904
CDK5RAP30.897
GTF3C50.894
NUMA10.894
DVL20.89
TMEM2590.888
SNRNP700.887
XAB20.885
FADS30.881
GGA10.881

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.69
OR4F29-0.67
MTRNR2L9-0.289
OR4F16-0.283
MTRNR2L6-0.281
TTLL10-AS1-0.259
KLRB1-0.256
MTRNR2L10-0.238
XCL2-0.237
TTLL10-0.232

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C547126AZM551248AZM551248 results in increased expression of STARD3 mRNA22323515
D004958EstradiolEstradiol results in increased expression of STARD3 mRNA15289156
C006780bisphenol Abisphenol A results in increased expression of STARD3 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of STARD3 mRNA22079614
D002104CadmiumCadmium results in decreased expression of STARD3 mRNA24067728
D002994ClofibrateClofibrate results in decreased expression of STARD3 mRNA23811191
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of STARD3 mRNA15289156
D004147DioxinsDioxins affects the expression of STARD3 mRNA20463971
D018120FinasterideFinasteride results in increased expression of STARD3 mRNA24136188
D019833GenisteinGenistein results in increased expression of STARD3 mRNA15289156
D017313FenretinideFenretinide results in increased expression of STARD3 mRNA28973697
D008731MethoxychlorMethoxychlor results in decreased expression of STARD3 mRNA21276474
C028007nickel monoxidenickel monoxide results in increased expression of STARD3 mRNA19167457
C059514resveratrolresveratrol results in increased expression of STARD3 mRNA22610192
D013467SulindacSulindac results in increased expression of STARD3 mRNA24136188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STARD3 mRNA21570461
D014520UrethaneUrethane results in increased expression of STARD3 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of STARD3 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of STARD3 gene29154799
D014638VanadatesVanadates results in decreased expression of STARD3 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of STARD3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15718238  24105263  25416956  28377464  
GO:0015485cholesterol binding-IDA12011453  15718238  28377464  
GO:0017127cholesterol transporter activity-IEA-  
GO:0042803protein homodimerization activity-IDA15718238  
GO ID GO Term Qualifier Evidence PubMed
GO:0006629lipid metabolic process-TAS7490069  
GO:0006700C21-steroid hormone biosynthetic process-TAS-  
GO:0006701progesterone biosynthetic process-IEA-  
GO:0006839mitochondrial transport-TAS9270027  
GO:0008202steroid metabolic process-TAS9139840  
GO:0008203cholesterol metabolic process-TAS9270027  
GO:0030301cholesterol transport-IDA28377464  
GO:0099044vesicle tethering to endoplasmic reticulum-IDA24105263  28377464  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS9139840  
GO:0005739mitochondrion-IEA-  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005789endoplasmic reticulum membranecolocalizes_withIDA24105263  28377464  
GO:0005829cytosol-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0031902late endosome membrane-IDA24105263  28377464  
GO:0044232organelle membrane contact site-IDA24105263  28377464  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196071Metabolism of steroid hormonesTAS
R-HSA-196108Pregnenolone biosynthesisTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28101967Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans. (2017 Jun)Bohn TMol Nutr Food Res
27058054Asthma susceptibility variants are more strongly associated with clinically similar subgroups. (2016 Nov)Lavoie-Charland EJ Asthma