Gene: CBX1

10951
CBX|HP1-BETA|HP1Hs-beta|HP1Hsbeta|M31|MOD1|p25beta
chromobox 1
protein-coding
17q21.32
Ensembl:ENSG00000108468 MIM:604511 Vega:OTTHUMG00000150417 UniprotKB:P83916
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.133e-2 (AD)  3.460e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OAZ20.964
YWHAQ0.947
C1orf430.943
GABARAPL20.943
EIF4H0.941
MRFAP10.935
MFF0.934
C22orf390.934
DNAJC80.932
HNRNPK0.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.84
OR4F29-0.837
MTRNR2L6-0.313
MTRNR2L10-0.283
C8orf74-0.277
MTRNR2L9-0.269
MTRNR2L3-0.263
DPPA4-0.258
FCER2-0.253
KRT73-0.246

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of CBX1 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of CBX1 mRNA]28655636
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBX1 mRNA"27188386
C016601afimoxifeneafimoxifene results in decreased expression of CBX1 mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CBX1 mRNA19770486
C040534alpha-hexachlorocyclohexanealpha-hexachlorocyclohexane results in decreased expression of CBX1 mRNA16940010
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CBX1 mRNA24449571
D001280AtrazineAtrazine results in increased expression of CBX1 mRNA25929836
D004958EstradiolEstradiol results in decreased expression of CBX1 mRNA15757668
D004958EstradiolEstradiol results in increased expression of CBX1 mRNA16514628
C044887beta-methylcholinebeta-methylcholine affects the expression of CBX1 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CBX1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of CBX1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CBX1 mRNA28628672
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CBX1 mRNA24763279
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CBX1 gene20938992
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of CBX1 mRNA19684285
D013759DronabinolDronabinol results in increased expression of CBX1 protein18163980
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CBX1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CBX1 mRNA28628672
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CBX1 mRNA17475347
D005472FluorouracilCBX1 protein affects the susceptibility to Fluorouracil16217747
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CBX1 gene20938992
C070081fulvestrantfulvestrant results in decreased expression of CBX1 mRNA16514628
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CBX1 mRNA24763279
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CBX1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CBX1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of CBX1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CBX1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CBX1 mRNA28628672
C410337K 7174K 7174 results in decreased expression of CBX1 mRNA24086573
D007649KetamineKetamine results in decreased expression of CBX1 mRNA20080153
C008261lead acetatelead acetate results in decreased expression of CBX1 mRNA21829687
D008353MannitolMannitol results in increased expression of CBX1 mRNA25270620
D008694MethamphetamineMethamphetamine results in decreased expression of CBX1 mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CBX1 gene20938992
D008777MethyltestosteroneMethyltestosterone results in decreased expression of CBX1 mRNA29191790
C022838nickel chloridenickel chloride affects the expression of CBX1 mRNA21496282
D019319Okadaic AcidOkadaic Acid results in increased expression of CBX1 mRNA25270620
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CBX1 mRNA25729387
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of CBX1 mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of CBX1 mRNA28655636
D010416PentachlorophenolPentachlorophenol results in increased expression of CBX1 mRNA23892564
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBX1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CBX1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of CBX1 mRNA18445702
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of CBX1 mRNA16514628
C059514resveratrolresveratrol results in decreased expression of CBX1 mRNA25905778
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CBX1 mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of CBX1 mRNA21297353
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of CBX1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CBX1 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CBX1 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of CBX1 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CBX1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of CBX1 protein16569592
D014212TretinoinEHMT2 protein promotes the reaction [Tretinoin promotes the reaction [CBX1 protein binds to POU5F1 promoter]]16415856
D014212TretinoinEHMT2 protein promotes the reaction [Tretinoin promotes the reaction [CBX1 protein binds to ZFP42 promoter]]16415856
D014212TretinoinTretinoin promotes the reaction [[HIST3H3 protein modified form binds to CBX1 protein] which binds to POU5F1 promoter]16415856
D014212TretinoinTretinoin promotes the reaction [[HIST3H3 protein modified form binds to CBX1 protein] which binds to ZFP42 promoter]16415856
C012589trichostatin Atrichostatin A results in decreased expression of CBX1 mRNA15901671
C057693troglitazonetroglitazone results in decreased expression of CBX1 mRNA19140230
D014635Valproic AcidValproic Acid affects the expression of CBX1 mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of CBX1 mRNA15901671
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of CBX1 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of CBX1 mRNA28655636
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CBX1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of CBX1 mRNA18042343

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-TAS9169582  
GO:0005515protein binding-IPI9636146  11242053  16415788  16615912  20195357  20850016  
20871592  21346195  21383955  21888893  27705803  29568061  
GO:0019899enzyme binding-IPI19486527  
GO:0042803protein homodimerization activity-IEA-  
GO:1990226histone methyltransferase binding-IPI19486527  
GO ID GO Term Qualifier Evidence PubMed
GO:0045892negative regulation of transcription, DNA-templated-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000775chromosome, centromeric region-IDA8287692  
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0000784nuclear chromosome, telomeric regioncolocalizes_withIDA24270157  
GO:0000785chromatin-IDA11101528  
GO:0001939female pronucleus-IEA-  
GO:0001940male pronucleus-IEA-  
GO:0005634nucleus-IDA21383955  
GO:0005654nucleoplasm-TAS9169582  
GO:0005720nuclear heterochromatin-TAS9169582  
GO:0005721pericentric heterochromatin-IEA-  
GO:0005819spindle-IDA11101528  
GO:0010369chromocenter-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29464021Association of serum levels of antibodies against MMP1, CBX1, and CBX5 with transient ischemic attack and cerebral infarction. (2018 Jan 19)Wang HOncotarget