Gene: ERP29

10961
C12orf8|ERp28|ERp31|HEL-S-107|PDI-DB|PDIA9
endoplasmic reticulum protein 29
protein-coding
12q24.13
Ensembl:ENSG00000089248 MIM:602287 Vega:OTTHUMG00000169637 UniprotKB:P30040
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.549e-2 (AD)  3.014e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLTA0.941
CUTA0.94
NHP20.937
PDAP10.937
AP2S10.935
COX5A0.934
PSMD80.932
NEDD80.931
DCTN30.931
NDUFAB10.931

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.725
OR4F29-0.705
MTRNR2L6-0.369
MTRNR2L9-0.351
MTRNR2L10-0.343
IL18RAP-0.338
P2RY14-0.337
KCNJ15-0.326
CXCR2-0.322
CXCR1-0.319

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of ERP29 mRNA"19162173
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ERP29 mRNA"21346803
C1217077,3'-dihydroxy-4'-methoxyisoflavone"7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of ERP29 protein"24455688
D000082AcetaminophenAcetaminophen affects the expression of ERP29 mRNA17562736
C000188alachloralachlor results in increased expression of ERP29 mRNA12419858
D000638AmiodaroneAmiodarone affects the expression of ERP29 mRNA18355885|1948338
D000639AmitriptylineAmitriptyline affects the expression of ERP29 mRNA18355885
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ERP29 mRNA16483693
D000661Amphetamine[MDK gene mutant form results in decreased susceptibility to Amphetamine] which results in increased expression of and results in increased phosphorylation of ERP29 protein23459167
D000661Amphetamine[PTN gene mutant form results in decreased susceptibility to Amphetamine] which results in increased expression of and results in increased phosphorylation of ERP29 protein23459167
D047310ApigeninApigenin results in increased expression of ERP29 mRNA22359648
D001151ArsenicArsenic results in increased expression of ERP29 protein19818359
C547126AZM551248AZM551248 results in increased expression of ERP29 mRNA22323515
D001553BenzbromaroneBenzbromarone affects the expression of ERP29 mRNA19483382
C095105bexarotenebexarotene results in increased expression of ERP29 mRNA16648578
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ERP29 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ERP29 mRNA25181051
C032036bromobenzenebromobenzene metabolite binds to ERP29 protein12018992
D002065BuspironeBuspirone results in decreased expression of ERP29 mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ERP29 mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ERP29 protein21699967
D002994ClofibrateClofibrate results in decreased expression of ERP29 mRNA17585979
D002994ClofibrateClofibrate affects the expression of ERP29 mRNA19483382
D002994ClofibrateClofibrate results in decreased expression of ERP29 mRNA21318169
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ERP29 mRNA17602206
D002997ClomipramineClomipramine affects the expression of ERP29 mRNA18355885
C030973cupric oxidecupric oxide analog results in increased expression of ERP29 protein23882024
D003676DeferoxamineDeferoxamine results in decreased expression of ERP29 protein19515424
D003676Deferoxamineferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ERP29 protein]19515424
D003907DexamethasoneDexamethasone results in increased expression of ERP29 mRNA21356098
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ERP29 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of ERP29 mRNA14618091
D003976DiazinonDiazinon results in increased methylation of ERP29 gene22964155
C000944dicrotophosdicrotophos results in decreased expression of ERP29 mRNA28302478
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of ERP29 mRNA21318169
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ERP29 mRNA17602206
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of ERP29 protein"22248470
C024629dimethyl phthalatedimethyl phthalate affects the expression of ERP29 mRNA26924002
D004298DopamineDopamine results in increased expression of ERP29 mRNA21983523
D004317DoxorubicinERP29 protein results in decreased susceptibility to Doxorubicin20833165
D004317DoxorubicinHSPB1 protein promotes the reaction [ERP29 protein results in decreased susceptibility to Doxorubicin]20833165
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ERP29 mRNA22079256
D000431EthanolEthanol results in increased expression of ERP29 protein20621659
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ERP29 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ERP29 mRNA17942748
D005001EthionineEthionine affects the expression of ERP29 mRNA19483382
C506425eurycomanoneeurycomanone results in decreased expression of ERP29 mRNA21903368
C506425eurycomanoneeurycomanone results in decreased expression of ERP29 protein21903368
D018818FenoldopamFenoldopam results in increased expression of ERP29 mRNA21983523
C013531ferric ammonium citrateferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ERP29 protein]19515424
D005411Flame RetardantsFlame Retardants results in decreased expression of ERP29 protein18550172
D005459FluoridesFluorides results in decreased expression of ERP29 protein19497429
D005472FluorouracilFluorouracil results in decreased expression of ERP29 protein15585135|1680352
D005485FlutamideFlutamide results in decreased expression of ERP29 mRNA24136188
D005897GlafenineGlafenine results in increased expression of ERP29 mRNA24136188
D006820Hyaluronic AcidHyaluronic Acid analog results in decreased expression of ERP29 protein23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of ERP29 protein23178681
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of ERP29 mRNA19376150
D007099ImipramineImipramine affects the expression of ERP29 mRNA18355885
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ERP29 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ERP29 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ERP29 mRNA28628672
D007529Isoflavones"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of ERP29 protein"22248470
D007545IsoproterenolIsoproterenol results in increased expression of ERP29 mRNA21335049
C544151jinfukangjinfukang results in increased expression of ERP29 mRNA27392435
D007654KetoconazoleKetoconazole affects the expression of ERP29 mRNA18355885
D008148LovastatinLovastatin results in decreased expression of ERP29 mRNA20493250
D008727MethotrexateMethotrexate results in decreased expression of ERP29 protein24736981
C063855microcystin RRmicrocystin RR results in decreased expression of ERP29 protein19111056
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ERP29 mRNA26924002
D009255NafenopinNafenopin results in decreased expression of ERP29 protein10903494
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ERP29 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ERP29 mRNA"25926378
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ERP29 mRNA"25554681|2562005
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of ERP29 protein19716841
C025256nonylphenolnonylphenol results in decreased expression of ERP29 protein19260726
D009853OmeprazoleOmeprazole affects the expression of ERP29 mRNA19483382
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of ERP29 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of ERP29 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of ERP29 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of ERP29 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of ERP29 mRNA]17655762
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of ERP29 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of ERP29 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of ERP29 mRNA]17655762
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of ERP29 protein18550172
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ERP29 mRNA19162173|2131816
D010634PhenobarbitalPhenobarbital results in increased expression of ERP29 mRNA19162173|2131816
C006253pirinixic acidpirinixic acid affects the expression of ERP29 mRNA19483382
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ERP29 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ERP29 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of ERP29 protein18563748
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ERP29 mRNA19162173|2131816
D011441PropylthiouracilPropylthiouracil affects the expression of ERP29 mRNA19483382
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of ERP29 mRNA25626140
D011794QuercetinQuercetin results in increased expression of ERP29 mRNA21356098
D011794QuercetinQuercetin results in decreased expression of ERP29 protein14750173
D011794QuercetinQuercetin results in increased expression of ERP29 protein17292933
D012715Sesame OilSesame Oil results in decreased expression of ERP29 mRNA29191790
C016104sodium bichromatesodium bichromate results in increased expression of ERP29 mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of ERP29 mRNA22561333
D012999SomanSoman results in increased expression of ERP29 mRNA19281266
D013605T-2 ToxinT-2 Toxin affects the expression of ERP29 protein26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ERP29 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ERP29 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ERP29 protein15822908
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of ERP29 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ERP29 mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of ERP29 mRNA19483382
C009495titanium dioxidetitanium dioxide results in increased expression of ERP29 mRNA23557971
C082097tocotrienol, delta"tocotrienol, delta results in increased expression of ERP29 mRNA"21356098
D014303TrinitrotolueneTrinitrotoluene affects the expression of ERP29 mRNA21346803
C057693troglitazonetroglitazone results in increased expression of ERP29 protein21315101
C080163trovafloxacintrovafloxacin results in decreased expression of ERP29 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased methylation of ERP29 gene29154799
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of ERP29 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of ERP29 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of ERP29 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ERP29 gene25560391
D012256RiboflavinRiboflavin results in increased expression of ERP29 mRNA21356098
D014859WarfarinWarfarin results in decreased expression of ERP29 mRNA20493250

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003756protein disulfide isomerase activityNOTIKR9738895  
GO:0042803protein homodimerization activity-ISS-  
GO:0051087chaperone binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IDA22064321  
GO:0001934positive regulation of protein phosphorylation-IDA22064321  
GO:0006457protein folding-NAS9738895  
GO:0006886intracellular protein transport-NAS9738895  
GO:0009306protein secretion-IEA-  
GO:0010628positive regulation of gene expression-IDA22064321  
GO:0010629negative regulation of gene expression-IDA22064321  
GO:0043335protein unfolding-NAS22064321  
GO:0050709negative regulation of protein secretion-IDA22064321  
GO:1902235regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA9738895  
GO:0005788endoplasmic reticulum lumen-NAS22064321  
GO:0005790smooth endoplasmic reticulum-ISS-  
GO:0009986cell surface-IDA19995400  
GO:0016020membrane-HDA19946888  
GO:0030133transport vesicle-ISS-  
GO:0042470melanosome-IEA-  
KEGG ID KEGG Term
hsa04141Protein processing in endoplasmic reticulum
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25803269Maternal Smoking Dysregulates Protein Expression in Second Trimester Human Fetal Livers in a Sex-Specific Manner. (2015 Jun)Filis PJ Clin Endocrinol Metab