Gene: STIP1

10963
HEL-S-94n|HOP|IEF-SSP-3521|P60|STI1|STI1L
stress induced phosphoprotein 1
protein-coding
11q13.1
Ensembl:ENSG00000168439 MIM:605063 Vega:OTTHUMG00000167789 UniprotKB:P31948
NC_000011.10
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.529e-1 (AD)  7.991e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FKBP40.97
AHSA10.958
DNAJA10.931
RBM40.923
DEDD20.92
DNAJB60.918
CCT30.916
HSPH10.913
CACYBP0.911
HSPA40.909

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.592
OR4F29-0.55
CC2D2B-0.358
KLRF1-0.33
CNGA1-0.312
CCT6B-0.311
KLRB1-0.309
IL18RAP-0.309
COX4I2-0.299
CEACAM4-0.292

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0245661,1,1-trichloroethane"1,1,1-trichloroethane results in increased expression of STIP1 mRNA"25270620
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of STIP1 mRNA"20453058
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of STIP1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of STIP1 mRNA"21346803
C0247092,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone"2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone binds to STIP1 protein"16533022
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of STIP1 mRNA"18648102
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of STIP1 mRNA"21346803
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to STIP1 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to STIP1 protein]26598702
C1217077,3'-dihydroxy-4'-methoxyisoflavone"7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of STIP1 protein"24455688
D000082AcetaminophenAcetaminophen results in increased expression of STIP1 mRNA21420995
D020106AcrylamideAcrylamide results in increased expression of STIP1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of STIP1 mRNA22100608
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of STIP1 mRNA"23195993
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of STIP1 protein26072098
D000643Ammonium ChlorideAmmonium Chloride affects the expression of STIP1 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of STIP1 mRNA12205029
D003913DextroamphetamineSOD1 inhibits the reaction [Dextroamphetamine results in increased expression of STIP1 mRNA]12205029
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to STIP1 protein]26598702
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STIP1 mRNA22300585
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of STIP1 mRNA"20018196
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of STIP1 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of STIP1 mRNA20106945
D004958EstradiolEstradiol results in increased expression of STIP1 mRNA14664709
C110172BHTOH-QMBHTOH-QM binds to STIP1 protein16533022
C053541bicalutamidebicalutamide results in decreased expression of STIP1 mRNA15638997
C006780bisphenol Abisphenol A affects the expression of STIP1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of STIP1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of STIP1 mRNA28628672
D000069286BortezomibBortezomib results in decreased expression of STIP1 mRNA20977926
D000069286BortezomibBortezomib results in increased expression of STIP1 mRNA17895889
C013418bromfenacoumbromfenacoum results in increased expression of STIP1 protein28903499
C018475butyraldehydebutyraldehyde results in increased expression of STIP1 mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of STIP1 mRNA26191083
D002104CadmiumCadmium affects the reaction [Tetrachlorodibenzodioxin affects the expression of STIP1 protein]29107029
D019256Cadmium ChlorideCadmium Chloride results in increased expression of STIP1 mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in increased expression of STIP1 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in increased expression of STIP1 mRNA18636176
C037123cadmium sulfatecadmium sulfate results in increased expression of STIP1 mRNA12064557|1467641
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of STIP1 mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STIP1 mRNA]"20230807
D000069287CapecitabineSTIP1 protein results in decreased susceptibility to Capecitabine16734730
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of STIP1 mRNA18804290
C100187chloropicrinchloropicrin results in increased expression of STIP1 mRNA26352163
D002793Cholic Acids[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of STIP1 mRNA27344345
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of STIP1 mRNA28472532
D002994ClofibrateClofibrate affects the expression of STIP1 mRNA23811191
C018021cobaltous chloridecobaltous chloride results in increased expression of STIP1 mRNA24612858
C018021cobaltous chloridecobaltous chloride results in increased expression of STIP1 mRNA24386269
D003300CopperSTIP1 protein binds to Copper15359738
D019327Copper SulfateCopper Sulfate results in increased expression of STIP1 mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of STIP1 mRNA19167446
C029892cupric chloridecupric chloride results in increased expression of STIP1 protein21641295
D003520CyclophosphamideCyclophosphamide results in decreased expression of STIP1 mRNA15331540
D003520CyclophosphamideCyclophosphamide results in decreased expression of STIP1 mRNA11906922
D016572CyclosporineCyclosporine results in increased expression of STIP1 mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of STIP1 mRNA28628672
D003976DiazinonDiazinon results in increased methylation of STIP1 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of STIP1 mRNA17361019
D002945CisplatinCisplatin results in decreased expression of STIP1 mRNA27594783
D004041Dietary FatsDietary Fats results in decreased expression of STIP1 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of STIP1 mRNA21318169
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased metabolism of STIP1 protein29267982
C025034doxifluridineSTIP1 protein results in decreased susceptibility to doxifluridine16734730
D004317DoxorubicinDoxorubicin affects the expression of STIP1 protein29385562
D004317DoxorubicinSTIP1 protein results in decreased susceptibility to Doxorubicin24675091
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of STIP1 mRNA"23811387
D004642EmodinEmodin results in decreased expression of STIP1 mRNA16045814
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of STIP1 mRNA20064776
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of STIP1 protein23301498
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of STIP1 mRNA27344345
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of STIP1 mRNA23649840
D018120FinasterideFinasteride results in increased expression of STIP1 mRNA24136188
D005411Flame RetardantsFlame Retardants results in decreased expression of STIP1 protein18550172
D005411Flame RetardantsFlame Retardants results in increased expression of STIP1 protein18550172
D005485FlutamideFlutamide results in increased expression of STIP1 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of STIP1 mRNA23649840
C106014geduningedunin results in increased expression of STIP1 mRNA17010675
D005839GentamicinsGentamicins results in increased expression of STIP1 mRNA22061828
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers results in increased expression of STIP1 protein24239914
D006493HeparinHeparin results in increased expression of STIP1 protein17488504
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of STIP1 protein]23178681
D006820Hyaluronic AcidHyaluronic Acid analog results in decreased expression of STIP1 protein23178681
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of STIP1 protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of STIP1 protein23178681
C492448ICG 001ICG 001 results in decreased expression of STIP1 mRNA26191083
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of STIP1 mRNA"26377693
C020758indium trichlorideindium trichloride results in increased expression of STIP1 protein19539025
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of STIP1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of STIP1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of STIP1 mRNA28628672
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of STIP1 mRNA12832151
C008261lead acetatelead acetate results in decreased expression of STIP1 mRNA21829687
D008094LithiumLithium results in increased expression of STIP1 protein18296634
D008148LovastatinLovastatin results in decreased expression of STIP1 mRNA20493250
D008464MecamylamineMecamylamine results in decreased expression of STIP1 mRNA16949557
D008627Mercuric ChlorideMercuric Chloride affects the expression of STIP1 mRNA20353558
D008627Mercuric ChlorideMercuric Chloride results in increased expression of STIP1 mRNA16507785
D008694MethamphetamineMethamphetamine results in decreased expression of STIP1 protein19826936
D008694MethamphetamineMethamphetamine results in increased expression of STIP1 mRNA19149911|1956491
D008748MethylcholanthreneMethylcholanthrene results in increased expression of STIP1 mRNA18804290
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of STIP1 mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of STIP1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of STIP1 mRNA23649840
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STIP1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of STIP1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STIP1 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of STIP1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STIP1 mRNA]"20230807
D015741MetriboloneMetribolone affects the localization of STIP1 protein17440980
D015741MetriboloneMetribolone results in increased expression of STIP1 protein17152098
D052998MicrocystinsMicrocystins results in increased expression of STIP1 protein22430071
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of STIP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of STIP1 mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of STIP1 mRNA23811387
C051752nefazodonenefazodone results in increased expression of STIP1 mRNA24136188
D009532NickelNickel results in decreased expression of STIP1 mRNA23195993
D009532NickelNickel results in increased expression of STIP1 mRNA24768652
D009538NicotineNicotine results in decreased expression of STIP1 mRNA16949557
D009538NicotineTubocurarine inhibits the reaction [Nicotine results in decreased expression of STIP1 mRNA]16949557
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of STIP1 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STIP1 mRNA]"20230807
C012655nimesulidenimesulide results in increased expression of STIP1 mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of STIP1 mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of STIP1 protein19716841
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of STIP1 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of STIP1 protein25937538
D017239PaclitaxelPaclitaxel results in increased expression of STIP1 protein15907983
D000073878Palm OilPalm Oil results in decreased expression of STIP1 mRNA18042831
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of STIP1 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of STIP1 protein18550172
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of STIP1 protein18550172
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of STIP1 protein19954255
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of STIP1 protein25616259
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of STIP1 protein22609092
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of STIP1 mRNA18804290
D010634PhenobarbitalPhenobarbital affects the expression of STIP1 mRNA23091169
D010634PhenobarbitalPhenobarbital affects the expression of STIP1 mRNA19162173
D010695PhlorhizinPhlorhizin results in decreased expression of STIP1 mRNA22538082
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of STIP1 mRNA22484513
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of STIP1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of STIP1 mRNA18301758|2131816
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of STIP1 mRNA]21318169
C006253pirinixic acidpirinixic acid results in increased expression of STIP1 mRNA19162173
D010894PiroxicamPiroxicam results in increased expression of STIP1 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of STIP1 mRNA23557933
D011374ProgesteroneProgesterone affects the expression of STIP1 mRNA17251523
C059514resveratrolresveratrol results in decreased expression of STIP1 protein23724044
D015474IsotretinoinIsotretinoin results in decreased expression of STIP1 mRNA18769122
D012524SarinSarin affects the expression of STIP1 protein28973502
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of STIP1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of STIP1 mRNA25351596
C016104sodium bichromatesodium bichromate results in increased expression of STIP1 mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of STIP1 mRNA22561333
D013749TetrachlorodibenzodioxinCadmium affects the reaction [Tetrachlorodibenzodioxin affects the expression of STIP1 protein]29107029
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STIP1 protein29107029
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STIP1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STIP1 mRNA20959002|2121527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of STIP1 protein16548065
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of STIP1 mRNA25613284
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of STIP1 protein"25852303
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of STIP1 mRNA22363418|2806579
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of STIP1 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of STIP1 mRNA19042947
C050414tripterinetripterine results in increased expression of STIP1 mRNA17010675
C080163trovafloxacintrovafloxacin results in decreased expression of STIP1 mRNA24136188
D014403TubocurarineTubocurarine inhibits the reaction [Nicotine results in decreased expression of STIP1 mRNA]16949557
D014403TubocurarineTubocurarine results in decreased expression of STIP1 mRNA16949557
C406224valdecoxibvaldecoxib results in increased expression of STIP1 mRNA24136188
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of STIP1 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of STIP1 mRNA19165385
D014750VincristineVincristine results in decreased expression of STIP1 mRNA23649840
C111237vorinostatvorinostat results in increased expression of STIP1 protein20543569
D014859WarfarinWarfarin results in decreased expression of STIP1 mRNA20493250
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of STIP1 mRNA18593933
D015032ZincZinc deficiency results in decreased expression of STIP1 mRNA12888634

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0005515protein binding-IPI20029029  21044950  21170051  21360678  23349634  23431407  
24880080  25036637  27353360  28330616  
GO:0008022protein C-terminus binding-IEA-  
GO:0030544Hsp70 protein binding-IEA-  
GO:0051087chaperone binding-IEA-  
GO:0051879Hsp90 protein binding-IBA21873635  
GO:0051879Hsp90 protein binding-IPI29127155  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-TAS16130169  
GO:0005794Golgi apparatus-TAS1569099  
GO:0005829cytosol-TAS-  
GO:0032991protein-containing complex-IDA23349634  
GO:0043209myelin sheath-IEA-  
GO:0101031chaperone complex-IDA29127155  
KEGG ID KEGG Term
hsa05020Prion diseases
Reactome ID Reactome Term Evidence
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3371497HSP90 chaperone cycle for steroid hormone receptors (SHR)TAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24673601GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids. (2014 May)Izuhara YAllergy