Gene: IFI44L

10964
C1orf29|GS3686
interferon induced protein 44 like
protein-coding
1p31.1
Ensembl:ENSG00000137959 MIM:613975 Vega:OTTHUMG00000009724 UniprotKB:Q53G44
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.831e-1 (AD)  2.796e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03607951chr1:79085586IFI44L8.550e-9Alcohol consumption per day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IFI440.916
OAS30.886
OAS20.88
EPSTI10.833
XAF10.83
OAS10.828
IFIH10.826
RSAD20.817
MX20.816
DDX580.803

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HRH3-0.254
FAM43B-0.252
C19orf73-0.234
ASPDH-0.233
HYAL3-0.224
ZNF835-0.22
MYADML2-0.218
BRDT-0.217
TTC9B-0.216
FBLL1-0.214

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IFI44L mRNA"23146750
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of IFI44L mRNA"19167446
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of IFI44L mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of IFI44L mRNA]28655636
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IFI44L mRNA"23146750
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of IFI44L mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI44L mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of IFI44L mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI44L mRNA"27188386
D012436S-AdenosylmethionineS-Adenosylmethionine results in decreased expression of IFI44L mRNA18098314
D001151ArsenicArsenic affects the methylation of IFI44L gene25304211
D001379AzathioprineAzathioprine results in decreased expression of IFI44L mRNA19192274
D001554BenzeneBenzene results in decreased expression of IFI44L mRNA19162166
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of IFI44L mRNA19619570
D004958EstradiolEstradiol results in decreased expression of IFI44L mRNA21795739
D004958EstradiolEstradiol results in increased expression of IFI44L mRNA19619570|2118537
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of IFI44L mRNA17404688
C006780bisphenol Abisphenol A affects the expression of IFI44L mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of IFI44L mRNA26079696
D019256Cadmium ChlorideCadmium Chloride affects the expression of IFI44L mRNA18974090
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IFI44L mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of IFI44L mRNA17484886
C023676chloroquine diphosphatechloroquine diphosphate results in decreased expression of IFI44L mRNA19192274
C012843cinnamic aldehydecinnamic aldehyde results in decreased expression of IFI44L mRNA19524605
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of IFI44L mRNA"19167446
D016572CyclosporineCyclosporine results in increased expression of IFI44L mRNA22147139
D003703DemecolcineDemecolcine results in increased expression of IFI44L mRNA23649840
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of IFI44L mRNA28962523
D004008DiclofenacDiclofenac results in decreased expression of IFI44L mRNA19192274
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of IFI44L mRNA23876855
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of IFI44L mRNA18242016
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of IFI44L mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of IFI44L mRNA28937961
C064925gadodiamidegadodiamide results in increased expression of IFI44L mRNA20959327
D005839GentamicinsGentamicins results in increased expression of IFI44L mRNA22061828
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in decreased expression of IFI44L mRNA19192274
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IFI44L mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IFI44L mRNA23086925|2479639
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of IFI44L mRNA24231268
C008261lead acetatelead acetate affects the expression of IFI44L mRNA21829687
C008261lead acetatelead acetate results in decreased expression of IFI44L mRNA22609695
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of IFI44L mRNA21641980
D022542Measles-Mumps-Rubella VaccineIFI44L gene results in increased susceptibility to Measles-Mumps-Rubella Vaccine25344690
D008727MethotrexateMethotrexate results in decreased expression of IFI44L mRNA19192274
D008775MethylprednisoloneMethylprednisolone results in decreased expression of IFI44L mRNA19192274
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of IFI44L mRNA22108045|2387685
C047806monomethylpropionmonomethylpropion affects the expression of IFI44L mRNA22303338
D009532NickelNickel results in increased expression of IFI44L mRNA24768652|2558310
C022838nickel chloridenickel chloride results in increased expression of IFI44L mRNA21455298
D009538NicotineNicotine results in increased expression of IFI44L mRNA23825647
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of IFI44L mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of IFI44L mRNA25729387
D010081OxazoloneOxazolone results in increased expression of IFI44L mRNA18242016
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of IFI44L mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of IFI44L mRNA28655636
D010894PiroxicamPiroxicam results in decreased expression of IFI44L mRNA19192274
D011239PrednisolonePrednisolone results in decreased expression of IFI44L mRNA19192274
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of IFI44L mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of IFI44L mRNA19690047
D012822Silicon DioxideSilicon Dioxide results in increased expression of IFI44L mRNA22300531
C017947sodium arsenitesodium arsenite results in decreased expression of IFI44L mRNA23876855
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of IFI44L mRNA21641980
D013629TamoxifenTamoxifen results in increased expression of IFI44L mRNA19155303
C004648testosterone enanthatetestosterone enanthate affects the expression of IFI44L mRNA17440010
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of IFI44L mRNA27914987
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of IFI44L mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IFI44L mRNA19619570
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IFI44L mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of IFI44L mRNA28065790
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of IFI44L mRNA"18242016
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of IFI44L mRNA25729387
D019772TopotecanTopotecan results in increased expression of IFI44L mRNA25729387
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI44L mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of IFI44L mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of IFI44L mRNA17292431
D014640VancomycinVancomycin results in decreased expression of IFI44L mRNA18930951
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of IFI44L mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of IFI44L mRNA28655636
C025643vinclozolinvinclozolin results in increased expression of IFI44L mRNA23034163
D014750VincristineVincristine results in increased expression of IFI44L mRNA23649840
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI44L mRNA20370541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005525GTP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0051607defense response to virus-IDA21478870  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29762635An Epigenome-Wide Association Study (EWAS) of Obesity-Related Traits. (2018 May 14)Dhana KAm J Epidemiol