Gene: FERMT2

10979
KIND2|MIG2|PLEKHC1|UNC112|UNC112B|mig-2
fermitin family member 2
protein-coding
14q22.1
Ensembl:ENSG00000073712 MIM:607746 Vega:OTTHUMG00000140309 UniprotKB:Q96AC1
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.966e-2 (AD)  5.987e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPNE30.939
YAP10.934
SDC20.919
RHOBTB30.918
PDLIM50.917
LRP100.913
CYBRD10.908
FGF20.902
DPY19L30.899
S1PR10.899

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.52
CALHM1-0.516
AGMAT-0.509
ADRA1D-0.499
CACNA1F-0.476
RHO-0.474
RTP1-0.474
MYOZ3-0.47
SLC7A4-0.469
TRABD2A-0.466

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FERMT2 mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of FERMT2 mRNA"21346803
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of FERMT2 mRNA21983209
C006632arsenic trioxidearsenic trioxide results in increased expression of FERMT2 mRNA27829220
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FERMT2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FERMT2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FERMT2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FERMT2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FERMT2 mRNA"19150397|2001819
D004958EstradiolEstradiol affects the expression of FERMT2 mRNA15721199
C006780bisphenol Abisphenol A results in decreased expression of FERMT2 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of FERMT2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FERMT2 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of FERMT2 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of FERMT2 mRNA26079696
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of FERMT2 mRNA23650126
C100187chloropicrinchloropicrin results in increased expression of FERMT2 mRNA26352163
D002922CiguatoxinsCiguatoxins affects the expression of FERMT2 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in decreased expression of FERMT2 mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of FERMT2 mRNA20971185
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FERMT2 mRNA"19167446
D016572CyclosporineCyclosporine results in increased expression of FERMT2 mRNA25562108
C004742daidzeindaidzein affects the expression of FERMT2 mRNA15721199
D003907DexamethasoneDexamethasone results in increased expression of FERMT2 mRNA25047013
D003976DiazinonDiazinon results in increased methylation of FERMT2 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FERMT2 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FERMT2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of FERMT2 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of FERMT2 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of FERMT2 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of FERMT2 mRNA]19030233
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of FERMT2 mRNA25242112
D004054DiethylstilbestrolDiethylstilbestrol affects the expression of FERMT2 mRNA15721199
D004237DiuronDiuron results in decreased expression of FERMT2 mRNA25152437
D004237DiuronDiuron results in increased expression of FERMT2 mRNA21551480
D004391DustDust results in increased expression of FERMT2 mRNA17805423
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of FERMT2 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FERMT2 mRNA22079256
C082360fipronilfipronil results in increased expression of FERMT2 mRNA23962444
D005472FluorouracilFERMT2 protein affects the susceptibility to Fluorouracil16217747
D005557FormaldehydeFormaldehyde results in decreased expression of FERMT2 mRNA20655997
D005557FormaldehydeFormaldehyde results in increased expression of FERMT2 mRNA27664576
D005897GlafenineGlafenine results in decreased expression of FERMT2 mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of FERMT2 mRNA22634610
D017313FenretinideFenretinide results in increased expression of FERMT2 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FERMT2 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of FERMT2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of FERMT2 mRNA27392435
D048628KetolidesKetolides analog results in increased expression of FERMT2 mRNA24967691
D007657Ketone BodiesKetone Bodies results in increased expression of FERMT2 mRNA16807920
C045463leflunomideleflunomide results in increased expression of FERMT2 mRNA28988120
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FERMT2 mRNA28001369
C008493methylselenic acidmethylselenic acid results in increased expression of FERMT2 mRNA18548127
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of FERMT2 protein24625837
C523799MRK 003FERMT2 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of FERMT2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FERMT2 mRNA"25554681|2562005
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of FERMT2 mRNA19074003
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of FERMT2 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of FERMT2 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of FERMT2 mRNA25729387
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of FERMT2 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of FERMT2 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of FERMT2 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of FERMT2 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of FERMT2 mRNA]17655762
C016030pantogabpantogab results in decreased expression of FERMT2 mRNA17379144
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of FERMT2 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of FERMT2 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of FERMT2 mRNA]17655762
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of FERMT2 mRNA18593933
D010416PentachlorophenolPentachlorophenol results in decreased expression of FERMT2 mRNA23892564
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of FERMT2 mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of FERMT2 mRNA23091169
D048789PhytoestrogensPhytoestrogens affects the expression of FERMT2 mRNA15721199
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FERMT2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of FERMT2 mRNA18445702
D010938Plant OilsPlant Oils results in increased expression of FERMT2 mRNA23370395
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FERMT2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FERMT2 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of FERMT2 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of FERMT2 mRNA20864642
D011794QuercetinQuercetin results in decreased expression of FERMT2 mRNA21632981
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of FERMT2 mRNA]19030233
D012822Silicon DioxideSilicon Dioxide results in increased expression of FERMT2 mRNA25351596
C009277sodium arsenatesodium arsenate results in increased expression of FERMT2 mRNA21795629
D012969Sodium FluorideSodium Fluoride results in decreased expression of FERMT2 protein28918527
D018038Sodium SeleniteSodium Selenite results in decreased expression of FERMT2 mRNA18175754
D018038Sodium SeleniteSodium Selenite results in decreased expression of FERMT2 mRNA23274088
D053260SootSoot results in decreased expression of FERMT2 mRNA26551751
D019311StaurosporineStaurosporine affects the expression of FERMT2 mRNA15721199
C004648testosterone enanthatetestosterone enanthate affects the expression of FERMT2 mRNA17440010
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of FERMT2 mRNA19074003
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FERMT2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of FERMT2 mRNA23557971
D019772TopotecanFERMT2 protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of FERMT2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of FERMT2 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of FERMT2 mRNA21934132
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of FERMT2 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased expression of FERMT2 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of FERMT2 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of FERMT2 mRNA17963808
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of FERMT2 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of FERMT2 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of FERMT2 mRNA]17655762
D014750VincristineVincristine results in increased expression of FERMT2 mRNA23649840
C111237vorinostatvorinostat results in increased expression of FERMT2 mRNA18769122
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of FERMT2 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI22699938  
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding-IDA21325030  22030399  
GO ID GO Term Qualifier Evidence PubMed
GO:0007160cell-matrix adhesion-IMP21325030  
GO:0007160cell-matrix adhesion-ISS-  
GO:0007179transforming growth factor beta receptor signaling pathway-IMP21325030  
GO:0007229integrin-mediated signaling pathway-IMP21325030  
GO:0008360regulation of cell shape-IEA-  
GO:0016055Wnt signaling pathway-IMP22699938  
GO:0033622integrin activation-IMP22030399  
GO:0034329cell junction assembly-TAS-  
GO:0034446substrate adhesion-dependent cell spreading-ISS-  
GO:0048041focal adhesion assembly-ISS-  
GO:0072657protein localization to membrane-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001725stress fiber-IEA-  
GO:0005634nucleus-IDA22699938  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA22699938  
GO:0005829cytosol-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IDA21325030  
GO:0005938cell cortex-IEA-  
GO:0009986cell surface-IEA-  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IDA21325030  
GO:0031258lamellipodium membrane-IEA-  
GO:0031674I band-IEA-  
GO:0031941filamentous actin-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-446353Cell-extracellular matrix interactionsTAS
R-HSA-446728Cell junction organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget