Gene: MAPRE2

10982
CSCSC2|EB1|EB2|RP1
microtubule associated protein RP/EB family member 2
protein-coding
18q12.1-q12.2
Ensembl:ENSG00000166974 MIM:605789 Vega:OTTHUMG00000132551 UniprotKB:Q15555
NG_047123.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.308e-1 (AD)  8.079e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7228414chr18:35054670 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11672277chr18:32556104MAPRE26.930e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAD23B0.968
UBQLN10.962
WDR820.957
RANBP90.956
SENP20.954
CSNK2A10.954
XPO70.953
SPIN10.953
ATXN7L3B0.952
KAT70.952

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.683
OR4F29-0.644
MTRNR2L6-0.347
CSAG1-0.346
KLRB1-0.342
MTRNR2L10-0.34
ASB4-0.32
IL18RAP-0.32
FZD10-0.32
MTRNR2L9-0.319

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of MAPRE2 mRNA"19031421
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MAPRE2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAPRE2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAPRE2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of MAPRE2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MAPRE2 gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAPRE2 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MAPRE2 mRNA19770486
C044887beta-methylcholinebeta-methylcholine affects the expression of MAPRE2 mRNA21179406
D001663BilirubinBilirubin results in decreased expression of MAPRE2 mRNA20196124
C006780bisphenol Abisphenol A results in increased expression of MAPRE2 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of MAPRE2 mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of MAPRE2 mRNA26191083
C054133casticincasticin results in increased expression of MAPRE2 mRNA28444820
C059262cidofovircidofovir results in increased expression of MAPRE2 mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of MAPRE2 mRNA25596134
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of MAPRE2 mRNA24690739
D016572CyclosporineCyclosporine results in decreased expression of MAPRE2 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of MAPRE2 mRNA25596134
D016572CyclosporineCyclosporine results in decreased expression of MAPRE2 mRNA19770486
C000944dicrotophosdicrotophos results in increased expression of MAPRE2 mRNA28302478
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of MAPRE2 mRNA24690739
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAPRE2 mRNA"27188386
D017313FenretinideFenretinide results in decreased expression of MAPRE2 mRNA28973697
D007052IbuprofenIbuprofen affects the expression of MAPRE2 mRNA17070997
C492448ICG 001ICG 001 results in decreased expression of MAPRE2 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MAPRE2 mRNA25613284
D007854LeadLead affects the expression of MAPRE2 mRNA28903495
C045463leflunomideleflunomide results in decreased expression of MAPRE2 mRNA24136188
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MAPRE2 mRNA21641980
C030667methylazoxymethanolmethylazoxymethanol results in increased expression of MAPRE2 mRNA17107856
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MAPRE2 protein25809596
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MAPRE2 mRNA"20188158
C008493methylselenic acidmethylselenic acid results in increased expression of MAPRE2 mRNA18548127
D015741MetriboloneMetribolone results in decreased expression of MAPRE2 mRNA17010675
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MAPRE2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MAPRE2 mRNA"25554681|2562005
D019319Okadaic AcidOkadaic Acid affects the expression of MAPRE2 mRNA23561263
C006253pirinixic acidpirinixic acid results in decreased expression of MAPRE2 mRNA18445702|2081375
C006253pirinixic acidpirinixic acid results in increased expression of MAPRE2 mRNA17426115
C116926rofecoxibrofecoxib results in decreased expression of MAPRE2 mRNA17070997
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MAPRE2 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MAPRE2 mRNA22903824
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAPRE2 mRNA21570461
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of MAPRE2 mRNA19031421
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MAPRE2 mRNA25613284
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of MAPRE2 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of MAPRE2 mRNA28973697
D014520UrethaneUrethane results in increased expression of MAPRE2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of MAPRE2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MAPRE2 mRNA23179753|2800136

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  25416956  27107012  27173435  
GO:0008017microtubule binding-IBA21873635  
GO:0008017microtubule binding-IEA-  
GO:0042802identical protein binding-IPI16189514  25416956  
GO:0051010microtubule plus-end binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007049cell cycle-IEA-  
GO:0007165signal transduction-TAS9233623  
GO:0008283cell proliferation-TAS9233623  
GO:0031110regulation of microtubule polymerization or depolymerization-IBA21873635  
GO:0035372protein localization to microtubule-IBA21873635  
GO:0051225spindle assembly-IBA21873635  
GO:0051301cell division-IEA-  
GO:1904825protein localization to microtubule plus-end-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-HDA16791210  
GO:0005815microtubule organizing center-IBA21873635  
GO:0005874microtubule-IBA21873635  
GO:0005881cytoplasmic microtubule-IBA21873635  
GO:0015630microtubule cytoskeleton-IDA-  
GO:0035371microtubule plus-end-IBA21873635  
GO:0035371microtubule plus-end-IEA-  
GO:0051233spindle midzone-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal