Gene: KCNQ1OT1

10984
KCNQ1-AS2|KCNQ10T1|Kncq1|KvDMR1|KvLQT1-AS|LIT1|NCRNA00012
KCNQ1 opposite strand/antisense transcript 1
ncRNA
11p15.5
Ensembl:ENSG00000269821 MIM:604115
NG_016178.2
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.188e-3 (AD)  5.830e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12574151chr11:2659888 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05740879chr11:2721866KCNQ1OT1Promoter4.124e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRR260.792
PRDM140.764
OR56A40.763
POU5F20.761
PRSS480.76
IFNK0.758
MTRNR2L50.758
PRAMEF170.754
TAS2R300.753
OR10K10.747

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KAZALD1-0.337
FBXL22-0.303
CTXN3-0.298
ARL9-0.297
F7-0.295
NEK2-0.292
FAM149A-0.292
PAH-0.29
CSDC2-0.288
HDDC3-0.288

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in decreased expression of KCNQ1OT1 mRNA"26377693
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of KCNQ1OT1 mRNA"26377693
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of KCNQ1OT1 mRNA"28073004
D000082AcetaminophenAcetaminophen results in increased expression of KCNQ1OT1 mRNA21420995
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of KCNQ1OT1 mRNA24449571
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of KCNQ1OT1 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of KCNQ1OT1 mRNA26377693
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of KCNQ1OT1 mRNA27685785
C006780bisphenol Abisphenol A results in decreased methylation of KCNQ1OT1 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of KCNQ1OT1 mRNA23593014
D003033Coal TarCoal Tar results in decreased expression of KCNQ1OT1 mRNA27858113
D002945Cisplatin[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of KCNQ1OT1 mRNA23625948
D005557FormaldehydeFormaldehyde results in increased expression of KCNQ1OT1 mRNA20655997
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of KCNQ1OT1 mRNA21641980
D008727MethotrexateMethotrexate results in increased expression of KCNQ1OT1 mRNA24449571
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of KCNQ1OT1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KCNQ1OT1 mRNA"25620056
D010416PentachlorophenolPentachlorophenol results in increased expression of KCNQ1OT1 mRNA23892564
D010634PhenobarbitalPhenobarbital results in decreased expression of KCNQ1OT1 mRNA23091169
C009277sodium arsenatesodium arsenate results in increased expression of KCNQ1OT1 mRNA21795629
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of KCNQ1OT1 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KCNQ1OT1 mRNA24680724
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of KCNQ1OT1 gene26756918
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of KCNQ1OT1 mRNA28065790
D014212TretinoinTretinoin results in increased expression of KCNQ1OT1 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of KCNQ1OT1 mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of KCNQ1OT1 mRNA26705709
D014635Valproic AcidValproic Acid results in increased methylation of KCNQ1OT1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0006342chromatin silencing-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal