Gene: COPS5

10987
CSN5|JAB1|MOV-34|SGN5
COP9 signalosome subunit 5
protein-coding
8q13.1
Ensembl:ENSG00000121022 MIM:604850 Vega:OTTHUMG00000164563 UniprotKB:Q92905
NC_000008.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.181e-1 (AD)  9.739e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EMC30.956
CSE1L0.952
MRPS230.951
PSMC10.95
PSMD140.949
MAGEH10.947
ATXN100.947
CCT70.945
MRPL450.944
TRAPPC30.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.681
OR4F29-0.645
MTRNR2L6-0.371
KLRB1-0.36
P2RY14-0.349
IL18RAP-0.347
C8orf74-0.345
MTRNR2L9-0.342
MMP9-0.341
MTRNR2L10-0.337

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of COPS5 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of COPS5 mRNA21420995
D000661AmphetamineAmphetamine results in increased expression of COPS5 protein23459167
C006632arsenic trioxide[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of COPS5 protein17077332
C006632arsenic trioxidearsenic trioxide results in decreased expression of and results in increased localization of COPS5 protein20698225
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of COPS5 mRNA22209252
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of COPS5 mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of COPS5 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of COPS5 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of COPS5 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of COPS5 mRNA26982218
C006780bisphenol Abisphenol A results in increased expression of COPS5 mRNA25181051
C089595cylindrospermopsincylindrospermopsin results in increased expression of COPS5 mRNA24921660
D016190CarboplatinCOPS5 results in increased susceptibility to Carboplatin21755009
D002945CisplatinCOPS5 results in increased susceptibility to Cisplatin21755009
C000944dicrotophosdicrotophos results in decreased expression of COPS5 mRNA28302478
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of COPS5 mRNA"22485181
D004281Docosahexaenoic Acids[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of COPS5 protein17077332
D004642Emodin[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of COPS5 protein17077332
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of COPS5 mRNA19118595
D018120FinasterideFinasteride results in increased expression of COPS5 mRNA24136188
D005485FlutamideFlutamide results in increased expression of COPS5 mRNA24136188
C069837fullerene C60fullerene C60 results in decreased expression of COPS5 mRNA19167457
D006418HemeHeme metabolite results in increased expression of COPS5 mRNA19191707
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of COPS5 mRNA20044591
D007213IndomethacinIndomethacin results in increased expression of COPS5 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COPS5 mRNA25613284
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of COPS5 mRNA23458150
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of COPS5 protein26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of COPS5 mRNA26011545
C051752nefazodonenefazodone results in increased expression of COPS5 mRNA24136188
C012655nimesulidenimesulide results in increased expression of COPS5 mRNA24136188
C006253pirinixic acidpirinixic acid results in increased expression of COPS5 mRNA23811191
D010936Plant ExtractsPlant Extracts results in increased expression of COPS5 mRNA23557933
D011794QuercetinQuercetin results in decreased expression of COPS5 mRNA21632981
C009277sodium arsenatesodium arsenate results in increased expression of COPS5 mRNA23922661
D018038Sodium SeleniteSodium Selenite results in increased expression of COPS5 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of COPS5 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COPS5 mRNA25613284
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of COPS5 mRNA19042947
C406224valdecoxibvaldecoxib results in increased expression of COPS5 mRNA24136188
D001335Vehicle EmissionsVehicle Emissions affects the methylation of COPS5 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-TAS8837781  
GO:0003743translation initiation factor activity-TAS9341143  
GO:0004222metalloendopeptidase activity-IEA-  
GO:0004843thiol-dependent ubiquitin-specific protease activity-IDA19246649  
GO:0005515protein binding-IPI12082530  14993265  15234121  15304329  15480426  15757663  
15887118  16410250  17050680  18850735  19214193  19444310  
19615732  20399188  20978819  21499297  21625211  23776465  
23840749  24421388  25043011  26456823  27029275  27173435  
GO:0008237metallopeptidase activity-IBA21873635  
GO:0008237metallopeptidase activity-IMP19214193  
GO:0019784NEDD8-specific protease activity-IBA21873635  
GO:0019784NEDD8-specific protease activity-TAS-  
GO:0019899enzyme binding-IEA-  
GO:0035718macrophage migration inhibitory factor binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000338protein deneddylation-IBA21873635  
GO:0000338protein deneddylation-IDA19141280  
GO:0000338protein deneddylation-IMP19214193  
GO:0000715nucleotide-excision repair, DNA damage recognition-TAS-  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006366transcription by RNA polymerase II-TAS8837781  
GO:0006412translation-TAS9341143  
GO:0006413translational initiation-IEA-  
GO:0016579protein deubiquitination-IDA19246649  
GO:0043066negative regulation of apoptotic process-IMP20978819  
GO:0043687post-translational protein modification-TAS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16410250  
GO:0046328regulation of JNK cascade-IDA16410250  
GO:0051091positive regulation of DNA-binding transcription factor activity-IDA20978819  
GO:0051726regulation of cell cycle-IEA-  
GO:1903894regulation of IRE1-mediated unfolded protein response-IMP15234121  
GO:1990182exosomal secretion-IDA19246649  
GO ID GO Term Qualifier Evidence PubMed
GO:0000785chromatincolocalizes_withIDA20978819  
GO:0005634nucleus-IDA17050680  20978819  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA17050680  
GO:0005829cytosol-IDA20978819  
GO:0005829cytosol-TAS-  
GO:0005852eukaryotic translation initiation factor 3 complex-TAS9341143  
GO:0008021synaptic vesicle-IDA21102408  
GO:0008180COP9 signalosome-IBA21873635  
GO:0008180COP9 signalosome-IDA18850735  19214193  
GO:0030054cell junction-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5696394DNA Damage Recognition in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6781823Formation of TC-NER Pre-Incision ComplexTAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-73894DNA RepairTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-8951664NeddylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics