Gene: CHAD

1101
SLRR4A
chondroadherin
protein-coding
17q21.33
Ensembl:ENSG00000136457 MIM:602178 Vega:OTTHUMG00000162129 UniprotKB:O15335
NC_000017.11
PubMed
0   ANCO-SNPs
ND
3   
3.315e-1 (AD)  2.937e-1 (ND)   (Frontal_Cortex)
2.473e-1 (AD)  4.831e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SOX120.55
MZF10.539
ASIC10.526
ZNF4440.521
COL20A10.513
ACAP30.508
B4GALNT40.506
TNK20.505
QTRT10.502
NLGN30.5

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.351
TFPI2-0.349
HPD-0.333
IGFL3-0.331
CXCL3-0.322
TMEM95-0.321
SGMS2-0.317
SERPINE1-0.316
OR4F29-0.313
CNTF-0.31

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of CHAD mRNA"26377693
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of CHAD mRNA"20702594
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CHAD mRNA"28973690
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl affects the expression of CHAD mRNA"20702594
D000082AcetaminophenAcetaminophen results in decreased expression of CHAD mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of CHAD mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHAD mRNA16483693
D001151ArsenicArsenic affects the methylation of CHAD gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CHAD mRNA26001963
C006780bisphenol Abisphenol A results in decreased expression of CHAD mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CHAD mRNA21457566
D003300CopperCopper deficiency results in increased expression of CHAD mRNA26033743
D003471CuprizoneCuprizone results in increased expression of CHAD mRNA26577399
D004041Dietary FatsDietary Fats results in increased expression of CHAD mRNA18042831|2501614
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of CHAD promoter27415467
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CHAD mRNA17942748
D004397FonofosFonofos results in increased methylation of CHAD promoter22847954
C069837fullerene C60fullerene C60 results in decreased expression of CHAD mRNA19167457
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CHAD mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CHAD mRNA"25554681
C031721naphthalenenaphthalene analog results in decreased expression of CHAD mRNA24976557
C028007nickel monoxidenickel monoxide results in decreased expression of CHAD mRNA19167457
D000073878Palm OilPalm Oil results in increased expression of CHAD mRNA18042831
D010278ParathionParathion results in increased methylation of CHAD promoter22847954
D011441PropylthiouracilPropylthiouracil results in decreased expression of CHAD mRNA24780913
D012834SilverSilver results in increased expression of CHAD mRNA27131904
D053260SootSoot results in decreased expression of CHAD mRNA26551751
C012568terbufosterbufos results in increased methylation of CHAD promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CHAD mRNA20702594
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CHAD mRNA17942748
C009495titanium dioxidetitanium dioxide results in decreased expression of CHAD mRNA23409001|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CHAD mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CHAD mRNA18087596
D014635Valproic AcidValproic Acid affects the expression of CHAD mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0060348bone development-IEA-  
GO:1900155negative regulation of bone trabecula formation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
8138386The CHAD program for the control of cardiovascular risk factors in a Jerusalem community: a 24-year retrospect. (1994 Jan)Abramson JHIsr J Med Sci
7228646Evaluation of a community program for the control of cardiovascular risk factors: the CHAD program in Jerusalem. (1981 Feb-Mar)Abramson JHIsr J Med Sci
3749010Ten-year evaluation of hypertension, overweight, cholesterol, and smoking control: the CHAD program in Jerusalem. Community Syndrome of Hypertension, Atherosclerosis and Diabetes. (1986 May)Gofin JPrev Med