Gene: KLK11

11012
PRSS20|TLSP
kallikrein related peptidase 11
protein-coding
19q13.41
Ensembl:ENSG00000167757 MIM:604434 Vega:OTTHUMG00000182915 UniprotKB:Q9UBX7
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.293e-1 (AD)  4.072e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SERPINB50.787
LAD10.773
DSC30.738
SPRR2E0.695
SLURP10.688
NCCRP10.687
KRT6B0.686
SPINK50.677
KRT140.674
TACSTD20.672

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF835-0.288
PSPN-0.284
PNPO-0.279
HDDC3-0.273
KHK-0.268
TRAPPC9-0.266
MICU3-0.265
RPAP1-0.262
FAM50B-0.262
ZFP41-0.261

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of KLK11 mRNA17562736
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KLK11 mRNA19619570
D004958EstradiolEstradiol results in increased expression of KLK11 mRNA19619570|2118537
D003300CopperCopper deficiency results in increased expression of KLK11 mRNA26033743
D002945CisplatinKLK11 protein affects the susceptibility to Cisplatin16217747
C121718dicyclanildicyclanil results in increased expression of KLK11 mRNA15664270
D004041Dietary FatsDietary Fats results in increased expression of KLK11 mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of KLK11 mRNA26033743
D011374ProgesteroneProgesterone results in decreased expression of KLK11 mRNA22238285
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KLK11 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KLK11 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLK11 mRNA21296121|2315218
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of KLK11 mRNA20133372

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IEA-  
GO:0008236serine-type peptidase activity-TAS9765601  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA16502470  
GO:0005794Golgi apparatus-IEA-  
GO:0030141secretory granule-IBA21873635  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18316555A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma. (2008 Mar 1)Planque CClin Cancer Res