Gene: LILRA1

11024
CD85I|LIR-6|LIR6
leukocyte immunoglobulin like receptor A1
protein-coding
19q13.42
Ensembl:ENSG00000104974 MIM:604810 Vega:OTTHUMG00000065701 UniprotKB:O75019
NC_000019.10
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.127e-1 (AD)  3.542e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12980993chr19:54593944 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LILRB10.925
IKZF10.916
APBB1IP0.915
SYK0.908
NCKAP1L0.907
TLR10.906
PTPRC0.902
BIN20.901
LILRB40.899
HLA-DOA0.898

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.495
MAGIX-0.476
KCNIP3-0.459
CYP46A1-0.456
WNT7A-0.446
CHRNA4-0.44
DBP-0.439
TMEM179-0.438
FUT9-0.438
BDH1-0.438

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of LILRA1 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of LILRA1 mRNA"23195993
C068073Am 580Am 580 results in increased expression of LILRA1 mRNA16982809
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of LILRA1 mRNA24449571
D009532NickelNickel results in decreased expression of LILRA1 mRNA23195993
D009532NickelNickel results in increased expression of LILRA1 mRNA24768652|2558310
C089730rosiglitazonerosiglitazone results in increased expression of LILRA1 mRNA16982809
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of LILRA1 mRNA20370541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003823antigen binding-TAS9548455  
GO:0004888transmembrane signaling receptor activity-TAS9548455  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-IEA-  
GO:0006952defense response-TAS9548455  
GO:0007166cell surface receptor signaling pathway-TAS9548455  
GO:0050776regulation of immune response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04380Osteoclast differentiation
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21547531Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence. (2012 Feb)Wang KSJ Mol Neurosci