Gene info: ID 1103

Gene: CHAT

GENE ID: 1103

Synonyms: CHOACTASE|CMS1A|CMS1A2|CMS6

Description: choline O-acetyltransferase

Gene type: protein-coding

Location: 10q11.23

dbXrefs: Ensembl:ENSG00000070748 MIM:118490 Vega:OTTHUMG00000018198 UniprotKB:P28329

RefSeq: NG_011797.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 18

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.269e-1 (AD) 4.450e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DRD3	0.949
GPR101	0.947
SAG	0.945
SLC35D3	0.941
ENTHD1	0.938
DGKK	0.938
AMBN	0.926
GPR1	0.918
SLC18A3	0.915
TMPRSS6	0.912

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SLC17A7	-0.407
SYTL2	-0.373
NANOS3	-0.352
NEUROD2	-0.346
ALDH1A1	-0.338
GALNT9	-0.324
SOHLH1	-0.321
RNF182	-0.317
TNNT2	-0.315
NXPH3	-0.312

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00184	Nicotine	Small Molecule	54-11-5	Approved	Target
DB00122	Choline	Small Molecule	62-49-7	Approved\|Nutraceutical	Enzyme

ID	Drug Name	Action	PubMed
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CHAT mRNA"	20816883
C464538	(3,3-dibenzylimidazo(1,2-a)pyridin-2-(3H)-one)	"(3,3-dibenzylimidazo(1,2-a)pyridin-2-(3H)-one) results in increased activity of CHAT protein"	11885975
C012587	3,5,6-trichloro-2-pyridinol	"3,5,6-trichloro-2-pyridinol results in decreased activity of CHAT protein"	15541749
C024836	4-nitrophenol	4-nitrophenol results in decreased activity of CHAT protein	15541749
D000109	Acetylcholine	CHAT results in increased chemical synthesis of Acetylcholine	20338223
D000111	Acetylcysteine	Acetylcysteine results in increased expression of CHAT protein	25891525
D000111	Acetylcysteine	[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein	25891525
D000111	Acetylcysteine	Tobacco Smoke Pollution inhibits the reaction [[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein]	25891525
D020106	Acrylamide	Acrylamide results in decreased activity of CHAT protein	11779407
D020106	Acrylamide	Acrylamide results in decreased expression of CHAT mRNA	28959563
D020106	Acrylamide	NTF3 protein inhibits the reaction [Acrylamide results in decreased activity of CHAT protein]	11779407
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CHAT mRNA	26260870
D024502	alpha-Tocopherol	[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein	25891525
D024502	alpha-Tocopherol	Tobacco Smoke Pollution inhibits the reaction [[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein]	25891525
D000535	Aluminum	Aluminum results in decreased activity of CHAT protein	16724269
D000535	Aluminum	Aluminum results in decreased expression of CHAT protein	16928369
D000535	Aluminum	APP protein promotes the reaction [Aluminum results in decreased activity of CHAT protein]	16724269
D000535	Aluminum	meloxicam inhibits the reaction [Aluminum results in decreased expression of CHAT protein]	16928369
C010845	aluminum chloride	aluminum chloride results in decreased expression of CHAT protein	18482095
C010845	aluminum chloride	caffeic acid inhibits the reaction [aluminum chloride results in decreased expression of CHAT protein]	18482095
C010845	aluminum chloride	aluminum chloride results in decreased activity of CHAT protein	2303807
C104223	aluminum lactate	aluminum lactate results in decreased activity of CHAT protein	7595502
D000638	Amiodarone	Amiodarone results in decreased expression of CHAT protein	25659768
D000639	Amitriptyline	Amitriptyline results in increased expression of CHAT mRNA	21820738
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CHAT mRNA	16483693
C015001	arsenite	arsenite results in increased methylation of CHAT promoter	23974009
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein	25891525
D001205	Ascorbic Acid	Tobacco Smoke Pollution inhibits the reaction [[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein]	25891525
D001374	Azacitidine	Azacitidine results in increased expression of CHAT mRNA	19151599
D001374	Azacitidine	Azacitidine results in increased expression of CHAT protein	19151599
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CHAT protein	28049045
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased activity of CHAT mRNA	22265711
C006780	bisphenol A	bisphenol A results in decreased expression of CHAT mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of CHAT gene	28505145
C018475	butyraldehyde	butyraldehyde results in increased expression of CHAT mRNA	26079696
D002101	Cacodylic Acid	Cacodylic Acid results in increased activity of CHAT protein	21440049
D002104	Cadmium	Cadmium results in decreased expression of CHAT mRNA	24376830
D019256	Cadmium Chloride	ACHE mRNA promotes the reaction [Cadmium Chloride results in decreased expression of CHAT protein]	27377441
D019256	Cadmium Chloride	Cadmium Chloride results in decreased activity of CHAT protein	25201352
D019256	Cadmium Chloride	[[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in decreased expression of CHAT protein	27377441
D019256	Cadmium Chloride	[Cadmium Chloride results in decreased activity of CHRM1 protein] which results in decreased expression of CHAT protein	27377441
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CHAT protein	27377441
D019256	Cadmium Chloride	CHRM1 mRNA inhibits the reaction [Cadmium Chloride results in decreased expression of CHAT protein]	27377441
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CHAT mRNA	27389774
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CHAT protein	27389774
D019256	Cadmium Chloride	Quercetin inhibits the reaction [Cadmium Chloride results in decreased expression of CHAT mRNA]	27389774
D019256	Cadmium Chloride	Quercetin inhibits the reaction [Cadmium Chloride results in decreased expression of CHAT protein]	27389774
C040048	caffeic acid	caffeic acid inhibits the reaction [aluminum chloride results in decreased expression of CHAT protein]	18482095
D002217	Carbachol	Carbachol results in decreased expression of CHAT mRNA	1317495
C078040	catalpol	catalpol inhibits the reaction [Galactose results in decreased activity of CHAT protein]	23612000
D004390	Chlorpyrifos	CHAT protein affects the reaction [Chlorpyrifos results in increased expression of ACHE mRNA]	26210949
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of CHAT mRNA	17452286\|1881221
C555710	chong-myung-tang	chong-myung-tang results in increased activity of CHAT protein	20673844
D003474	Curcumin	Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHAT protein]	21839772
D003484	Cyanamide	Cyanamide affects the reaction [Ethanol results in decreased expression of CHAT mRNA]	17045751
D003484	Cyanamide	Cyanamide affects the reaction [Ethanol results in decreased expression of CHAT protein]	17045751
C052570	cyfluthrin	cyfluthrin results in decreased expression of CHAT protein	26604153
D003561	Cytarabine	Cytarabine results in increased activity of CHAT protein	2900045
C004742	daidzein	daidzein results in increased activity of CHAT protein	16428827
D003671	DEET	[Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] results in increased activity of CHAT protein	11248143
D003976	Diazinon	Diazinon affects the expression of CHAT mRNA	16207942
D003976	Diazinon	Diazinon results in decreased activity of CHAT protein	16675431
D003976	Diazinon	Diazinon results in decreased expression of CHAT mRNA	17452286\|1881221
C020735	dibutyldichlorotin	dibutyldichlorotin results in decreased activity of CHAT protein	9015740
D003994	Bucladesine	[Bucladesine co-treated with Tretinoin] results in increased activity of CHAT protein	16724269
D003994	Bucladesine	Bucladesine results in increased expression of CHAT protein	20361958
D003994	Bucladesine	Nicotine promotes the reaction [Bucladesine results in increased expression of CHAT protein]	20361958
D004006	Dichlorvos	Dichlorvos results in increased activity of CHAT protein	17722737
D004041	Dietary Fats	Dietary Fats affects the reaction [Parathion affects the expression of CHAT protein]	19590683
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of CHAT mRNA	19542621
D004112	Dimercaprol	Dimercaprol inhibits the reaction [Mercury results in decreased activity of CHAT protein]	15795686
D016291	Dizocilpine Maleate	Dizocilpine Maleate inhibits the reaction [Quinolinic Acid results in decreased activity of CHAT protein]	2976130
D004317	Doxorubicin	Doxorubicin affects the methylation of CHAT gene	28962528
D004967	Estrogens	Estrogens affects the expression of CHAT mRNA	15893308
D004966	Estrogens, Conjugated (USP)	"Estrogens, Conjugated (USP) results in increased expression of CHAT protein"	19101559
D000431	Ethanol	Cyanamide affects the reaction [Ethanol results in decreased expression of CHAT mRNA]	17045751
D000431	Ethanol	Cyanamide affects the reaction [Ethanol results in decreased expression of CHAT protein]	17045751
D000431	Ethanol	Ethanol results in decreased expression of CHAT mRNA	17045751
D000431	Ethanol	Ethanol results in decreased expression of CHAT protein	17045751\|1910028
D005033	Ethylmaleimide	Ethylmaleimide results in decreased activity of CHAT protein	3437937
D005690	Galactose	catalpol inhibits the reaction [Galactose results in decreased activity of CHAT protein]	23612000
D005690	Galactose	Galactose results in decreased activity of CHAT protein	23612000
C049863	ginsenoside Rd	ginsenoside Rd results in increased expression of CHAT mRNA	24599032
C049863	ginsenoside Rd	ginsenoside Rd results in increased expression of CHAT protein	24599032
C049863	ginsenoside Rd	staurosporine aglycone inhibits the reaction [ginsenoside Rd results in increased expression of CHAT mRNA]	24599032
C049863	ginsenoside Rd	staurosporine aglycone inhibits the reaction [ginsenoside Rd results in increased expression of CHAT protein]	24599032
C049864	ginsenoside Re	ginsenoside Re results in increased expression of CHAT mRNA	24599032
C049864	ginsenoside Re	ginsenoside Re results in increased expression of CHAT protein	24599032
C049864	ginsenoside Re	staurosporine aglycone inhibits the reaction [ginsenoside Re results in increased expression of CHAT mRNA]	24599032
C049864	ginsenoside Re	staurosporine aglycone inhibits the reaction [ginsenoside Re results in increased expression of CHAT protein]	24599032
D012701	Serotonin	Serotonin analog inhibits the reaction [Scopolamine Hydrobromide results in decreased activity of CHAT protein]	26408985
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of CHAT protein	22381256
D006861	Hydrogen Peroxide	[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein	22381256
D006861	Hydrogen Peroxide	shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of CHAT protein]	22381256
D006861	Hydrogen Peroxide	staurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein]	22381256
D006861	Hydrogen Peroxide	[Hydrogen Peroxide co-treated with BDNF protein] results in increased expression of CHAT protein	22381256
D006861	Hydrogen Peroxide	staurosporine aglycone inhibits the reaction [[Hydrogen Peroxide co-treated with BDNF protein] results in increased expression of CHAT protein]	22381256
C499403	icaritin	icaritin results in increased expression of CHAT protein	19135036
D007294	Inositol	Inositol inhibits the reaction [Streptozocin affects the localization of CHAT protein]	2431858
D007461	Iodoacetates	Iodoacetates results in decreased activity of CHAT protein	3437937
C553674	kangshuai yizhi	kangshuai yizhi inhibits the reaction [Scopolamine Hydrobromide results in decreased activity of CHAT protein]	20694781
C008261	lead acetate	lead acetate results in decreased expression of CHAT mRNA	19737576
D008345	Manganese	Manganese results in decreased activity of CHAT protein	24885898
D008345	Manganese	Taurine inhibits the reaction [Manganese results in decreased activity of CHAT protein]	24885898
C065757	meloxicam	meloxicam inhibits the reaction [Aluminum results in decreased expression of CHAT protein]	16928369
D008628	Mercury	Dimercaprol inhibits the reaction [Mercury results in decreased activity of CHAT protein]	15795686
D008628	Mercury	Mercury results in decreased activity of CHAT protein	15795686
D008628	Mercury	Mercury results in decreased expression of CHAT mRNA	7781173
D008694	Methamphetamine	Methamphetamine results in decreased activity of CHAT protein	10089005
C054634	methyllycaconitine	methyllycaconitine inhibits the reaction [SLURP1 protein results in increased expression of CHAT]	24365495
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of CHAT mRNA	21145954
D009538	Nicotine	Nicotine inhibits the reaction [Vanadium results in decreased expression of CHAT protein]	22119111
D009538	Nicotine	Nicotine promotes the reaction [Bucladesine results in increased expression of CHAT protein]	20361958
D009538	Nicotine	Nicotine results in decreased activity of CHAT protein	21633116
D009538	Nicotine	Nicotine results in increased activity of CHAT protein	21633116
D009599	Nitroprusside	APP protein promotes the reaction [Nitroprusside results in decreased activity of CHAT protein]	16724269
D009599	Nitroprusside	Nitroprusside results in decreased activity of CHAT protein	16724269
C072936	notoginsenoside R1	notoginsenoside R1 results in increased expression of CHAT	25714973
C029407	oleylamide	oleylamide results in increased activity of CHAT protein	12843655
D010269	Paraquat	Paraquat results in decreased activity of CHAT protein	24521700
D010269	Paraquat	Paraquat results in decreased expression of CHAT mRNA	28916328
D010278	Parathion	Dietary Fats affects the reaction [Parathion affects the expression of CHAT protein]	19590683
D010278	Parathion	Parathion affects the expression of CHAT protein	18941570\|1959068
D010278	Parathion	Parathion results in decreased expression of CHAT protein	20015457
D010433	Pentylenetetrazole	[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of CHAT mRNA	21503142
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased activity of CHAT protein	12773772
D026023	Permethrin	Permethrin results in decreased activity of CHAT protein	1459649
D026023	Permethrin	[Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] results in increased activity of CHAT protein	11248143
D010830	Physostigmine	CHAT affects the susceptibility to Physostigmine	20338223
D010830	Physostigmine	Physostigmine results in decreased expression of CHAT protein	22640809
D010830	Physostigmine	Physostigmine results in increased expression of CHAT protein	22640809
D010862	Pilocarpine	Pilocarpine results in decreased activity of CHAT protein	19669875\|1993273
D010862	Pilocarpine	Pilocarpine results in decreased expression of CHAT protein	19941057
D010862	Pilocarpine	[Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein	19669875
D010936	Plant Extracts	Plant Extracts results in decreased expression of CHAT mRNA	23557933
D010936	Plant Extracts	Plant Extracts results in increased expression of CHAT protein	19463889
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons results in increased expression of CHAT protein	28049045
D011374	Progesterone	Progesterone inhibits the reaction [VPS54 gene mutant form results in decreased activity of CHAT protein]	17052708
D011374	Progesterone	Progesterone inhibits the reaction [VPS54 gene mutant form results in decreased expression of CHAT protein]	17052708
D011374	Progesterone	Progesterone inhibits the reaction [VPS54 mutant form results in decreased expression of CHAT protein]	19693665
C062916	protopanaxadiol	protopanaxadiol inhibits the reaction [Scopolamine Hydrobromide results in decreased activity of CHAT protein]	29133030
D011729	Pyridostigmine Bromide	[Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] results in increased activity of CHAT protein	11248143
D011794	Quercetin	Quercetin inhibits the reaction [Cadmium Chloride results in decreased expression of CHAT mRNA]	27389774
D011794	Quercetin	Quercetin inhibits the reaction [Cadmium Chloride results in decreased expression of CHAT protein]	27389774
D017378	Quinolinic Acid	Dizocilpine Maleate inhibits the reaction [Quinolinic Acid results in decreased activity of CHAT protein]	2976130
D017378	Quinolinic Acid	Quinolinic Acid results in decreased activity of CHAT protein	2976130
C059514	resveratrol	resveratrol results in increased expression of CHAT protein	23075401
D012524	Sarin	Sarin results in decreased expression of CHAT protein	22640809
D012601	Scopolamine Hydrobromide	kangshuai yizhi inhibits the reaction [Scopolamine Hydrobromide results in decreased activity of CHAT protein]	20694781
D012601	Scopolamine Hydrobromide	Scopolamine Hydrobromide results in decreased activity of CHAT protein	20694781
D012601	Scopolamine Hydrobromide	protopanaxadiol inhibits the reaction [Scopolamine Hydrobromide results in decreased activity of CHAT protein]	29133030
D012601	Scopolamine Hydrobromide	Scopolamine Hydrobromide results in decreased activity of CHAT protein	26408985\|2913303
D012601	Scopolamine Hydrobromide	Serotonin analog inhibits the reaction [Scopolamine Hydrobromide results in decreased activity of CHAT protein]	26408985
C040115	shogaol	[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein	22381256
C040115	shogaol	shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of CHAT protein]	22381256
C040115	shogaol	[shogaol results in increased expression of BDNF protein] which results in increased expression of CHAT protein	22381256
C040115	shogaol	shogaol results in increased expression of CHAT protein	22381256
C040115	shogaol	staurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein]	22381256
D019821	Simvastatin	Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the activity of CHAT protein]	16828882
D019821	Simvastatin	Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHAT mRNA]	16828882
C027744	S-methylisothiopseudouronium	S-methylisothiopseudouronium inhibits the reaction [NGF protein results in increased activity of CHAT protein]	12065671
C027744	S-methylisothiopseudouronium	S-methylisothiopseudouronium inhibits the reaction [NGF protein results in increased expression of CHAT mRNA]	12065671
C017947	sodium arsenite	sodium arsenite results in increased activity of CHAT protein	3437937
C017947	sodium arsenite	Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHAT protein]	21839772
C017947	sodium arsenite	sodium arsenite results in decreased expression of CHAT protein	21839772\|2451789
C049985	staurosporine aglycone	staurosporine aglycone inhibits the reaction [ginsenoside Rd results in increased expression of CHAT mRNA]	24599032
C049985	staurosporine aglycone	staurosporine aglycone inhibits the reaction [ginsenoside Rd results in increased expression of CHAT protein]	24599032
C049985	staurosporine aglycone	staurosporine aglycone inhibits the reaction [ginsenoside Re results in increased expression of CHAT mRNA]	24599032
C049985	staurosporine aglycone	staurosporine aglycone inhibits the reaction [ginsenoside Re results in increased expression of CHAT protein]	24599032
C049985	staurosporine aglycone	staurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein]	22381256
C049985	staurosporine aglycone	staurosporine aglycone inhibits the reaction [[Hydrogen Peroxide co-treated with BDNF protein] results in increased expression of CHAT protein]	22381256
D013311	Streptozocin	Inositol inhibits the reaction [Streptozocin affects the localization of CHAT protein]	2431858
D013311	Streptozocin	Streptozocin affects the localization of CHAT protein	2431858
D013619	Tacrine	Tacrine results in increased expression of CHAT protein	15990178
D013654	Taurine	Taurine inhibits the reaction [Manganese results in decreased activity of CHAT protein]	24885898
D013853	Thioacetamide	Thioacetamide results in decreased expression of CHAT mRNA	23411599
D008063	Thioctic Acid	[Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein	19669875
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the activity of CHAT protein	27633979
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution inhibits the reaction [[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein]	25891525
D014212	Tretinoin	[Bucladesine co-treated with Tretinoin] results in increased activity of CHAT protein	16724269
D014212	Tretinoin	Tretinoin results in increased expression of CHAT mRNA	17203487
D014212	Tretinoin	Tretinoin results in increased expression of CHAT protein	19135036
C011559	tributyltin	tributyltin results in decreased activity of CHAT protein	9015740
D014403	Tubocurarine	Tubocurarine results in decreased expression of CHAT mRNA	1317495
D014639	Vanadium	Nicotine inhibits the reaction [Vanadium results in decreased expression of CHAT protein]	22119111
D014639	Vanadium	Vanadium results in decreased expression of CHAT protein	22119111
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of CHAT mRNA	23940539
D020888	Vigabatrin	[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of CHAT mRNA	21503142
C060637	zhi-mu saponin	zhi-mu saponin results in increased activity of CHAT protein	11668742

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004102	choline O-acetyltransferase activity	-	IBA	21873635
GO:0004102	choline O-acetyltransferase activity	-	TAS	-
GO:0008374	O-acyltransferase activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006656	phosphatidylcholine biosynthetic process	-	TAS	-
GO:0007269	neurotransmitter secretion	-	TAS	-
GO:0007274	neuromuscular synaptic transmission	-	IBA	21873635
GO:0008292	acetylcholine biosynthetic process	-	IBA	21873635
GO:0042136	neurotransmitter biosynthetic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	TAS	10861222
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	TAS	10861222
GO:0005829	cytosol	-	TAS	-
GO:0043005	neuron projection	-	IBA	21873635
GO:0098793	presynapse	-	IEA	-

KEGG ID	KEGG Term
hsa00564	Glycerophospholipid metabolism

Reactome ID	Reactome Term	Evidence
R-HSA-112310	Neurotransmitter release cycle	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-1483191	Synthesis of PC	TAS
R-HSA-1483206	Glycerophospholipid biosynthesis	TAS
R-HSA-1483257	Phospholipid metabolism	TAS
R-HSA-264642	Acetylcholine Neurotransmitter Release Cycle	TAS
R-HSA-556833	Metabolism of lipids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
15019433	Involvement of cholinergic neuronal systems in intravenous cocaine self-administration. (2004 Jan)	Smith JE	Neurosci Biobehav Rev
29273661	Design and rationale of the Cardiovascular Health and Text Messaging (CHAT) Study and the CHAT-Diabetes Mellitus (CHAT-DM) Study: two randomised controlled trials of text messaging to improve secondary prevention for coronary heart disease and diabetes. (2017 Dec 21)	Huo X	BMJ Open
17341425	The cutaneous non-neuronal cholinergic system and smoking related dermatoses: studies of the psoriasis variant palmoplantar pustulosis. (2007 May 30)	Hagforsen E	Life Sci
7877755	Choline acetyltransferase activity is reduced in rat nucleus accumbens after unlimited access to self-administration of cocaine. (1994 Oct 10)	Wilson JM	Neurosci Lett
24893293	Chronic alcohol consumption leads to neurochemical changes in the nucleus accumbens that are not fully reversed by withdrawal. (2014 Jul-Aug)	Pereira PA	Neurotoxicol Teratol
17673711	Visceral adipose tissue, a potential risk factor for carotid atherosclerosis: results of the Multicultural Community Health Assessment Trial (M-CHAT). (2007 Sep)	Lear SA	Stroke
28325449	TControl: A mobile app to follow up tobacco-quitting patients. (2017 Apr)	Pifarre M	Comput Methods Programs Biomed
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