Gene: CHAT

1103
CHOACTASE|CMS1A|CMS1A2|CMS6
choline O-acetyltransferase
protein-coding
10q11.23
Ensembl:ENSG00000070748 MIM:118490 Vega:OTTHUMG00000018198 UniprotKB:P28329
NG_011797.1
PubMed
CD|ND|AD
18   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.269e-1 (AD)  4.450e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DRD30.949
GPR1010.947
SAG0.945
SLC35D30.941
ENTHD10.938
DGKK0.938
AMBN0.926
GPR10.918
SLC18A30.915
TMPRSS60.912

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC17A7-0.407
SYTL2-0.373
NANOS3-0.352
NEUROD2-0.346
ALDH1A1-0.338
GALNT9-0.324
SOHLH1-0.321
RNF182-0.317
TNNT2-0.315
NXPH3-0.312

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00184NicotineSmall Molecule54-11-5ApprovedTarget
DB00122CholineSmall Molecule62-49-7Approved|NutraceuticalEnzyme
ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CHAT mRNA"20816883
C464538(3,3-dibenzylimidazo(1,2-a)pyridin-2-(3H)-one)"(3,3-dibenzylimidazo(1,2-a)pyridin-2-(3H)-one) results in increased activity of CHAT protein"11885975
C0125873,5,6-trichloro-2-pyridinol"3,5,6-trichloro-2-pyridinol results in decreased activity of CHAT protein"15541749
C0248364-nitrophenol4-nitrophenol results in decreased activity of CHAT protein15541749
D000109AcetylcholineCHAT results in increased chemical synthesis of Acetylcholine20338223
D000111AcetylcysteineAcetylcysteine results in increased expression of CHAT protein25891525
D000111Acetylcysteine[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein25891525
D000111AcetylcysteineTobacco Smoke Pollution inhibits the reaction [[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein]25891525
D020106AcrylamideAcrylamide results in decreased activity of CHAT protein11779407
D020106AcrylamideAcrylamide results in decreased expression of CHAT mRNA28959563
D020106AcrylamideNTF3 protein inhibits the reaction [Acrylamide results in decreased activity of CHAT protein]11779407
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CHAT mRNA26260870
D024502alpha-Tocopherol[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein25891525
D024502alpha-TocopherolTobacco Smoke Pollution inhibits the reaction [[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein]25891525
D000535AluminumAluminum results in decreased activity of CHAT protein16724269
D000535AluminumAluminum results in decreased expression of CHAT protein16928369
D000535AluminumAPP protein promotes the reaction [Aluminum results in decreased activity of CHAT protein]16724269
D000535Aluminummeloxicam inhibits the reaction [Aluminum results in decreased expression of CHAT protein]16928369
C010845aluminum chloridealuminum chloride results in decreased expression of CHAT protein18482095
C010845aluminum chloridecaffeic acid inhibits the reaction [aluminum chloride results in decreased expression of CHAT protein]18482095
C010845aluminum chloridealuminum chloride results in decreased activity of CHAT protein2303807
C104223aluminum lactatealuminum lactate results in decreased activity of CHAT protein7595502
D000638AmiodaroneAmiodarone results in decreased expression of CHAT protein25659768
D000639AmitriptylineAmitriptyline results in increased expression of CHAT mRNA21820738
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHAT mRNA16483693
C015001arsenitearsenite results in increased methylation of CHAT promoter23974009
D001205Ascorbic Acid[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein25891525
D001205Ascorbic AcidTobacco Smoke Pollution inhibits the reaction [[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein]25891525
D001374AzacitidineAzacitidine results in increased expression of CHAT mRNA19151599
D001374AzacitidineAzacitidine results in increased expression of CHAT protein19151599
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CHAT protein28049045
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased activity of CHAT mRNA22265711
C006780bisphenol Abisphenol A results in decreased expression of CHAT mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CHAT gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of CHAT mRNA26079696
D002101Cacodylic AcidCacodylic Acid results in increased activity of CHAT protein21440049
D002104CadmiumCadmium results in decreased expression of CHAT mRNA24376830
D019256Cadmium ChlorideACHE mRNA promotes the reaction [Cadmium Chloride results in decreased expression of CHAT protein]27377441
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of CHAT protein25201352
D019256Cadmium Chloride[[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in decreased expression of CHAT protein27377441
D019256Cadmium Chloride[Cadmium Chloride results in decreased activity of CHRM1 protein] which results in decreased expression of CHAT protein27377441
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CHAT protein27377441
D019256Cadmium ChlorideCHRM1 mRNA inhibits the reaction [Cadmium Chloride results in decreased expression of CHAT protein]27377441
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CHAT mRNA27389774
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CHAT protein27389774
D019256Cadmium ChlorideQuercetin inhibits the reaction [Cadmium Chloride results in decreased expression of CHAT mRNA]27389774
D019256Cadmium ChlorideQuercetin inhibits the reaction [Cadmium Chloride results in decreased expression of CHAT protein]27389774
C040048caffeic acidcaffeic acid inhibits the reaction [aluminum chloride results in decreased expression of CHAT protein]18482095
D002217CarbacholCarbachol results in decreased expression of CHAT mRNA1317495
C078040catalpolcatalpol inhibits the reaction [Galactose results in decreased activity of CHAT protein]23612000
D004390ChlorpyrifosCHAT protein affects the reaction [Chlorpyrifos results in increased expression of ACHE mRNA]26210949
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CHAT mRNA17452286|1881221
C555710chong-myung-tangchong-myung-tang results in increased activity of CHAT protein20673844
D003474CurcuminCurcumin inhibits the reaction [sodium arsenite results in decreased expression of CHAT protein]21839772
D003484CyanamideCyanamide affects the reaction [Ethanol results in decreased expression of CHAT mRNA]17045751
D003484CyanamideCyanamide affects the reaction [Ethanol results in decreased expression of CHAT protein]17045751
C052570cyfluthrincyfluthrin results in decreased expression of CHAT protein26604153
D003561CytarabineCytarabine results in increased activity of CHAT protein2900045
C004742daidzeindaidzein results in increased activity of CHAT protein16428827
D003671DEET[Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] results in increased activity of CHAT protein11248143
D003976DiazinonDiazinon affects the expression of CHAT mRNA16207942
D003976DiazinonDiazinon results in decreased activity of CHAT protein16675431
D003976DiazinonDiazinon results in decreased expression of CHAT mRNA17452286|1881221
C020735dibutyldichlorotindibutyldichlorotin results in decreased activity of CHAT protein9015740
D003994Bucladesine[Bucladesine co-treated with Tretinoin] results in increased activity of CHAT protein16724269
D003994BucladesineBucladesine results in increased expression of CHAT protein20361958
D003994BucladesineNicotine promotes the reaction [Bucladesine results in increased expression of CHAT protein]20361958
D004006DichlorvosDichlorvos results in increased activity of CHAT protein17722737
D004041Dietary FatsDietary Fats affects the reaction [Parathion affects the expression of CHAT protein]19590683
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CHAT mRNA19542621
D004112DimercaprolDimercaprol inhibits the reaction [Mercury results in decreased activity of CHAT protein]15795686
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [Quinolinic Acid results in decreased activity of CHAT protein]2976130
D004317DoxorubicinDoxorubicin affects the methylation of CHAT gene28962528
D004967EstrogensEstrogens affects the expression of CHAT mRNA15893308
D004966Estrogens, Conjugated (USP)"Estrogens, Conjugated (USP) results in increased expression of CHAT protein"19101559
D000431EthanolCyanamide affects the reaction [Ethanol results in decreased expression of CHAT mRNA]17045751
D000431EthanolCyanamide affects the reaction [Ethanol results in decreased expression of CHAT protein]17045751
D000431EthanolEthanol results in decreased expression of CHAT mRNA17045751
D000431EthanolEthanol results in decreased expression of CHAT protein17045751|1910028
D005033EthylmaleimideEthylmaleimide results in decreased activity of CHAT protein3437937
D005690Galactosecatalpol inhibits the reaction [Galactose results in decreased activity of CHAT protein]23612000
D005690GalactoseGalactose results in decreased activity of CHAT protein23612000
C049863ginsenoside Rdginsenoside Rd results in increased expression of CHAT mRNA24599032
C049863ginsenoside Rdginsenoside Rd results in increased expression of CHAT protein24599032
C049863ginsenoside Rdstaurosporine aglycone inhibits the reaction [ginsenoside Rd results in increased expression of CHAT mRNA]24599032
C049863ginsenoside Rdstaurosporine aglycone inhibits the reaction [ginsenoside Rd results in increased expression of CHAT protein]24599032
C049864ginsenoside Reginsenoside Re results in increased expression of CHAT mRNA24599032
C049864ginsenoside Reginsenoside Re results in increased expression of CHAT protein24599032
C049864ginsenoside Restaurosporine aglycone inhibits the reaction [ginsenoside Re results in increased expression of CHAT mRNA]24599032
C049864ginsenoside Restaurosporine aglycone inhibits the reaction [ginsenoside Re results in increased expression of CHAT protein]24599032
D012701SerotoninSerotonin analog inhibits the reaction [Scopolamine Hydrobromide results in decreased activity of CHAT protein]26408985
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CHAT protein22381256
D006861Hydrogen Peroxide[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein22381256
D006861Hydrogen Peroxideshogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of CHAT protein]22381256
D006861Hydrogen Peroxidestaurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein]22381256
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with BDNF protein] results in increased expression of CHAT protein22381256
D006861Hydrogen Peroxidestaurosporine aglycone inhibits the reaction [[Hydrogen Peroxide co-treated with BDNF protein] results in increased expression of CHAT protein]22381256
C499403icaritinicaritin results in increased expression of CHAT protein19135036
D007294InositolInositol inhibits the reaction [Streptozocin affects the localization of CHAT protein]2431858
D007461IodoacetatesIodoacetates results in decreased activity of CHAT protein3437937
C553674kangshuai yizhikangshuai yizhi inhibits the reaction [Scopolamine Hydrobromide results in decreased activity of CHAT protein]20694781
C008261lead acetatelead acetate results in decreased expression of CHAT mRNA19737576
D008345ManganeseManganese results in decreased activity of CHAT protein24885898
D008345ManganeseTaurine inhibits the reaction [Manganese results in decreased activity of CHAT protein]24885898
C065757meloxicammeloxicam inhibits the reaction [Aluminum results in decreased expression of CHAT protein]16928369
D008628MercuryDimercaprol inhibits the reaction [Mercury results in decreased activity of CHAT protein]15795686
D008628MercuryMercury results in decreased activity of CHAT protein15795686
D008628MercuryMercury results in decreased expression of CHAT mRNA7781173
D008694MethamphetamineMethamphetamine results in decreased activity of CHAT protein10089005
C054634methyllycaconitinemethyllycaconitine inhibits the reaction [SLURP1 protein results in increased expression of CHAT]24365495
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of CHAT mRNA21145954
D009538NicotineNicotine inhibits the reaction [Vanadium results in decreased expression of CHAT protein]22119111
D009538NicotineNicotine promotes the reaction [Bucladesine results in increased expression of CHAT protein]20361958
D009538NicotineNicotine results in decreased activity of CHAT protein21633116
D009538NicotineNicotine results in increased activity of CHAT protein21633116
D009599NitroprussideAPP protein promotes the reaction [Nitroprusside results in decreased activity of CHAT protein]16724269
D009599NitroprussideNitroprusside results in decreased activity of CHAT protein16724269
C072936notoginsenoside R1notoginsenoside R1 results in increased expression of CHAT25714973
C029407oleylamideoleylamide results in increased activity of CHAT protein12843655
D010269ParaquatParaquat results in decreased activity of CHAT protein24521700
D010269ParaquatParaquat results in decreased expression of CHAT mRNA28916328
D010278ParathionDietary Fats affects the reaction [Parathion affects the expression of CHAT protein]19590683
D010278ParathionParathion affects the expression of CHAT protein18941570|1959068
D010278ParathionParathion results in decreased expression of CHAT protein20015457
D010433Pentylenetetrazole[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of CHAT mRNA21503142
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased activity of CHAT protein12773772
D026023PermethrinPermethrin results in decreased activity of CHAT protein1459649
D026023Permethrin[Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] results in increased activity of CHAT protein11248143
D010830PhysostigmineCHAT affects the susceptibility to Physostigmine20338223
D010830PhysostigminePhysostigmine results in decreased expression of CHAT protein22640809
D010830PhysostigminePhysostigmine results in increased expression of CHAT protein22640809
D010862PilocarpinePilocarpine results in decreased activity of CHAT protein19669875|1993273
D010862PilocarpinePilocarpine results in decreased expression of CHAT protein19941057
D010862Pilocarpine[Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein19669875
D010936Plant ExtractsPlant Extracts results in decreased expression of CHAT mRNA23557933
D010936Plant ExtractsPlant Extracts results in increased expression of CHAT protein19463889
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons results in increased expression of CHAT protein28049045
D011374ProgesteroneProgesterone inhibits the reaction [VPS54 gene mutant form results in decreased activity of CHAT protein]17052708
D011374ProgesteroneProgesterone inhibits the reaction [VPS54 gene mutant form results in decreased expression of CHAT protein]17052708
D011374ProgesteroneProgesterone inhibits the reaction [VPS54 mutant form results in decreased expression of CHAT protein]19693665
C062916protopanaxadiolprotopanaxadiol inhibits the reaction [Scopolamine Hydrobromide results in decreased activity of CHAT protein]29133030
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with Permethrin co-treated with DEET] results in increased activity of CHAT protein11248143
D011794QuercetinQuercetin inhibits the reaction [Cadmium Chloride results in decreased expression of CHAT mRNA]27389774
D011794QuercetinQuercetin inhibits the reaction [Cadmium Chloride results in decreased expression of CHAT protein]27389774
D017378Quinolinic AcidDizocilpine Maleate inhibits the reaction [Quinolinic Acid results in decreased activity of CHAT protein]2976130
D017378Quinolinic AcidQuinolinic Acid results in decreased activity of CHAT protein2976130
C059514resveratrolresveratrol results in increased expression of CHAT protein23075401
D012524SarinSarin results in decreased expression of CHAT protein22640809
D012601Scopolamine Hydrobromidekangshuai yizhi inhibits the reaction [Scopolamine Hydrobromide results in decreased activity of CHAT protein]20694781
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in decreased activity of CHAT protein20694781
D012601Scopolamine Hydrobromideprotopanaxadiol inhibits the reaction [Scopolamine Hydrobromide results in decreased activity of CHAT protein]29133030
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in decreased activity of CHAT protein26408985|2913303
D012601Scopolamine HydrobromideSerotonin analog inhibits the reaction [Scopolamine Hydrobromide results in decreased activity of CHAT protein]26408985
C040115shogaol[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein22381256
C040115shogaolshogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of CHAT protein]22381256
C040115shogaol[shogaol results in increased expression of BDNF protein] which results in increased expression of CHAT protein22381256
C040115shogaolshogaol results in increased expression of CHAT protein22381256
C040115shogaolstaurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein]22381256
D019821SimvastatinSimvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the activity of CHAT protein]16828882
D019821SimvastatinSimvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHAT mRNA]16828882
C027744S-methylisothiopseudouroniumS-methylisothiopseudouronium inhibits the reaction [NGF protein results in increased activity of CHAT protein]12065671
C027744S-methylisothiopseudouroniumS-methylisothiopseudouronium inhibits the reaction [NGF protein results in increased expression of CHAT mRNA]12065671
C017947sodium arsenitesodium arsenite results in increased activity of CHAT protein3437937
C017947sodium arseniteCurcumin inhibits the reaction [sodium arsenite results in decreased expression of CHAT protein]21839772
C017947sodium arsenitesodium arsenite results in decreased expression of CHAT protein21839772|2451789
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [ginsenoside Rd results in increased expression of CHAT mRNA]24599032
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [ginsenoside Rd results in increased expression of CHAT protein]24599032
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [ginsenoside Re results in increased expression of CHAT mRNA]24599032
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [ginsenoside Re results in increased expression of CHAT protein]24599032
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein]22381256
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [[Hydrogen Peroxide co-treated with BDNF protein] results in increased expression of CHAT protein]22381256
D013311StreptozocinInositol inhibits the reaction [Streptozocin affects the localization of CHAT protein]2431858
D013311StreptozocinStreptozocin affects the localization of CHAT protein2431858
D013619TacrineTacrine results in increased expression of CHAT protein15990178
D013654TaurineTaurine inhibits the reaction [Manganese results in decreased activity of CHAT protein]24885898
D013853ThioacetamideThioacetamide results in decreased expression of CHAT mRNA23411599
D008063Thioctic Acid[Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein19669875
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the activity of CHAT protein27633979
D014028Tobacco Smoke PollutionTobacco Smoke Pollution inhibits the reaction [[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein]25891525
D014212Tretinoin[Bucladesine co-treated with Tretinoin] results in increased activity of CHAT protein16724269
D014212TretinoinTretinoin results in increased expression of CHAT mRNA17203487
D014212TretinoinTretinoin results in increased expression of CHAT protein19135036
C011559tributyltintributyltin results in decreased activity of CHAT protein9015740
D014403TubocurarineTubocurarine results in decreased expression of CHAT mRNA1317495
D014639VanadiumNicotine inhibits the reaction [Vanadium results in decreased expression of CHAT protein]22119111
D014639VanadiumVanadium results in decreased expression of CHAT protein22119111
D001335Vehicle EmissionsVehicle Emissions affects the expression of CHAT mRNA23940539
D020888Vigabatrin[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of CHAT mRNA21503142
C060637zhi-mu saponinzhi-mu saponin results in increased activity of CHAT protein11668742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004102choline O-acetyltransferase activity-IBA21873635  
GO:0004102choline O-acetyltransferase activity-TAS-  
GO:0008374O-acyltransferase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006656phosphatidylcholine biosynthetic process-TAS-  
GO:0007269neurotransmitter secretion-TAS-  
GO:0007274neuromuscular synaptic transmission-IBA21873635  
GO:0008292acetylcholine biosynthetic process-IBA21873635  
GO:0042136neurotransmitter biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-TAS10861222  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS10861222  
GO:0005829cytosol-TAS-  
GO:0043005neuron projection-IBA21873635  
GO:0098793presynapse-IEA-  
KEGG ID KEGG Term
hsa00564Glycerophospholipid metabolism
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1430728MetabolismTAS
R-HSA-1483191Synthesis of PCTAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-264642Acetylcholine Neurotransmitter Release CycleTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15019433Involvement of cholinergic neuronal systems in intravenous cocaine self-administration. (2004 Jan)Smith JENeurosci Biobehav Rev
29273661Design and rationale of the Cardiovascular Health and Text Messaging (CHAT) Study and the CHAT-Diabetes Mellitus (CHAT-DM) Study: two randomised controlled trials of text messaging to improve secondary prevention for coronary heart disease and diabetes. (2017 Dec 21)Huo XBMJ Open
17341425The cutaneous non-neuronal cholinergic system and smoking related dermatoses: studies of the psoriasis variant palmoplantar pustulosis. (2007 May 30)Hagforsen ELife Sci
7877755Choline acetyltransferase activity is reduced in rat nucleus accumbens after unlimited access to self-administration of cocaine. (1994 Oct 10)Wilson JMNeurosci Lett
24893293Chronic alcohol consumption leads to neurochemical changes in the nucleus accumbens that are not fully reversed by withdrawal. (2014 Jul-Aug)Pereira PANeurotoxicol Teratol
17673711Visceral adipose tissue, a potential risk factor for carotid atherosclerosis: results of the Multicultural Community Health Assessment Trial (M-CHAT). (2007 Sep)Lear SAStroke
28325449TControl: A mobile app to follow up tobacco-quitting patients. (2017 Apr)Pifarre MComput Methods Programs Biomed
10730754The distribution of choline acetyltransferase- and acetylcholinesterase-like immunoreactivity in the palmar skin of patients with palmoplantar pustulosis. (2000 Feb)Hagforsen EBr J Dermatol
26059306[Depression and addiction comorbidity: towards a common molecular target?]. (2015 May)Arango-Lievano MMed Sci (Paris)
19465085Combined exposure to nicotine and ethanol in adolescent mice: effects on the central cholinergic systems during short and long term withdrawal. (2009 Sep 15)Ribeiro-Carvalho ANeuroscience
14970833Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal. (2004 May)Abreu-Villaca YNeuropsychopharmacology
10744060Chronic prenatal exposure to carbon monoxide results in a reduction in tyrosine hydroxylase-immunoreactivity and an increase in choline acetyltransferase-immunoreactivity in the fetal medulla: implications for Sudden Infant Death Syndrome. (2000 Mar)Tolcos MJ Neuropathol Exp Neurol
26623516An essential role of acetylcholine-glutamate synergy at habenular synapses in nicotine dependence. (2015 Dec 1)Frahm SElife
6994921Prolonged ethanol consumption produces persistent alterations of cholinergic function in rat brain. (1980 Jul)Pelham RWAlcohol Clin Exp Res
24647098I'll txt U if I have a problem: how the Societe Canadienne du cancer in Quebec applied behavior-change theory, data mining and agile software development to help young adults quit smoking. (2014)van Mierlo TPLoS One
23987237Adiposity and the relationship between vitamin D and blood pressure. (2013 Dec)Sulistyoningrum DCMetabolism
23222296Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma. (2013 Feb 15)Lau JKCancer Res
15935216Neurochemical correlates of nicotine neurotoxicity on rat habenulo-interpeduncular cholinergic neurons. (2005 Jun)Ciani ENeurotoxicology