Gene: TENT4A

11044
LAK-1|LAK1|PAPD7|POLK|POLS|TRF4|TRF4-1|TRF41|TUTASE5
terminal nucleotidyltransferase 4A
protein-coding
5p15.31
Ensembl:ENSG00000112941 MIM:605198 Vega:OTTHUMG00000090457 UniprotKB:Q5XG87
NC_000005.10
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.890e-1 (AD)  7.629e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of TENT4A mRNA"19162173
C0127962-butenal2-butenal results in decreased expression of TENT4A mRNA20471460
D000082AcetaminophenAcetaminophen results in increased expression of TENT4A mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TENT4A gene27153756
D001280AtrazineAtrazine results in decreased expression of TENT4A mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TENT4A mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of TENT4A mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of TENT4A promoter22457795
C018021cobaltous chloridecobaltous chloride results in increased expression of TENT4A mRNA19376846
D003375CoumestrolCoumestrol results in increased expression of TENT4A mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of TENT4A mRNA20106945
D002945CisplatinCisplatin results in decreased expression of TENT4A mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of TENT4A mRNA28302478
C082360fipronilfipronil results in increased expression of TENT4A mRNA23962444
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TENT4A mRNA25613284
D016685MitomycinMitomycin results in decreased expression of TENT4A mRNA25270620
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TENT4A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TENT4A mRNA"25554681
D009532NickelNickel results in increased expression of TENT4A mRNA19031421
D009538NicotineNicotine results in increased splicing of TENT4A mRNA alternative form23825647
D010416PentachlorophenolPentachlorophenol results in increased expression of TENT4A mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TENT4A mRNA19162173
D010634PhenobarbitalPhenobarbital results in increased expression of TENT4A mRNA19162173
C006253pirinixic acidpirinixic acid results in decreased expression of TENT4A mRNA23811191
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TENT4A mRNA19162173
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TENT4A mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TENT4A mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TENT4A mRNA25613284
D014241TrichloroethyleneTrichloroethylene results in increased methylation of TENT4A gene27618143
D014635Valproic AcidValproic Acid results in decreased methylation of TENT4A gene29154799
C025643vinclozolinvinclozolin results in decreased expression of TENT4A mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of TENT4A mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004652polynucleotide adenylyltransferase activity-IBA21873635  
GO:0004652polynucleotide adenylyltransferase activity-IEA-  
GO:0005524ATP binding-IEA-  
GO:0043221SMC family protein binding-TAS10066793  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006302double-strand break repair-NAS10066793  
GO:0006378mRNA polyadenylation-IBA21873635  
GO:0006397mRNA processing-IEA-  
GO:0007062sister chromatid cohesion-TAS10066793  
GO:0007076mitotic chromosome condensation-NAS10066793  
GO:0042493response to drug-IDA10066793  
GO:0043630ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process-IBA21873635  
GO:0071035nuclear polyadenylation-dependent rRNA catabolic process-IBA21873635  
GO:0071036nuclear polyadenylation-dependent snoRNA catabolic process-IBA21873635  
GO:0071037nuclear polyadenylation-dependent snRNA catabolic process-IBA21873635  
GO:0071038nuclear polyadenylation-dependent tRNA catabolic process-IBA21873635  
GO:0071042nuclear polyadenylation-dependent mRNA catabolic process-IBA21873635  
GO:0071044histone mRNA catabolic process-IBA21873635  
GO:0071050snoRNA polyadenylation-IBA21873635  
GO:0071051polyadenylation-dependent snoRNA 3'-end processing-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10066793  
GO:0005654nucleoplasm-IDA-  
GO:0005730nucleolus-IBA21873635  
GO:0005794Golgi apparatus-IDA-  
GO:0031499TRAMP complex-IBA21873635  
GO:0031965nuclear membrane-IDA-  
KEGG ID KEGG Term
hsa03018RNA degradation
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802957Oncogenic MAPK signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal