Gene: CHD1

1105
PILBOS
chromodomain helicase DNA binding protein 1
protein-coding
5q15-q21.1
Ensembl:ENSG00000153922 MIM:602118 Vega:OTTHUMG00000162744 UniprotKB:O14646
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.814e-1 (AD)  1.557e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KAT6A0.861
NUP1600.858
ELK40.857
ZKSCAN80.848
ARID20.846
KDM5A0.834
PCF110.829
SMC50.827
ANKHD10.826
SLC30A70.826

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.391
OR4F29-0.389
HES5-0.289
CRH-0.285
CRYBA2-0.282
LYPD8-0.266
PRSS56-0.263
ASPDH-0.252
NANOS3-0.248
SPEF1-0.248

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00445EpirubicinSmall Molecule56420-45-2ApprovedTarget
ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CHD1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CHD1 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of CHD1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CHD1 gene27153756
D001280AtrazineAtrazine results in increased expression of CHD1 mRNA25929836
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CHD1 mRNA"19150397|2038263
C044887beta-methylcholinebeta-methylcholine affects the expression of CHD1 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CHD1 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CHD1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of CHD1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CHD1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CHD1 mRNA28628672
D002737ChloropreneChloroprene results in increased expression of CHD1 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in increased expression of CHD1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of CHD1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of CHD1 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of CHD1 mRNA19770486
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CHD1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CHD1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CHD1 mRNA28628672
D002945CisplatinCisplatin results in increased phosphorylation of CHD1 protein22006019
C000944dicrotophosdicrotophos results in decreased expression of CHD1 mRNA28302478
C121718dicyclanildicyclanil results in increased expression of CHD1 mRNA15664270
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CHD1 mRNA17942748
D005557FormaldehydeFormaldehyde results in decreased expression of CHD1 mRNA20655997|2364984
D005839GentamicinsGentamicins results in increased expression of CHD1 mRNA22061828
D007213IndomethacinIndomethacin results in decreased expression of CHD1 mRNA16984733
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CHD1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CHD1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CHD1 mRNA28628672
C051890irinotecanirinotecan metabolite results in decreased expression of CHD1 mRNA15956246
C051890irinotecanirinotecan results in decreased expression of CHD1 mRNA15956246
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CHD1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CHD1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CHD1 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of CHD1 mRNA27392435
C410337K 7174K 7174 results in increased expression of CHD1 mRNA24086573
D007854LeadLead affects the expression of CHD1 mRNA28903495
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CHD1 mRNA"26251327
D009151Mustard GasMustard Gas results in increased expression of CHD1 mRNA15674844
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CHD1 mRNA25729387
C016030pantogabpantogab results in increased expression of CHD1 mRNA17379144
D010416PentachlorophenolPentachlorophenol results in increased expression of CHD1 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CHD1 mRNA27153767
C049032pinosylvinpinosylvin results in increased expression of CHD1 mRNA23333577
C006253pirinixic acidpirinixic acid results in increased expression of CHD1 mRNA18445702
D010936Plant ExtractsPlant Extracts results in increased expression of CHD1 mRNA23557933
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of CHD1 mRNA19244175
D012643SeleniumSelenium results in decreased expression of CHD1 mRNA19244175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CHD1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CHD1 mRNA19770486
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CHD1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CHD1 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of CHD1 mRNA19448997
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CHD1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of CHD1 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of CHD1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of CHD1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of CHD1 gene29154799
C025643vinclozolinvinclozolin affects the expression of CHD1 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of CHD1 mRNA18042343
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of CHD1 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of CHD1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0004003ATP-dependent DNA helicase activity-TAS9326634  
GO:0005515protein binding-IPI22419161  26751641  
GO:0005524ATP binding-IEA-  
GO:0035064methylated histone binding-IDA21029866  
GO:0035064methylated histone binding-IMP28866611  
GO ID GO Term Qualifier Evidence PubMed
GO:0006338chromatin remodeling-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-TAS9326634  
GO:0016569covalent chromatin modification-IMP28866611  
GO:0032508DNA duplex unwinding-IEA-  
GO:0043923positive regulation by host of viral transcription-IMP25297984  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IDA22046413  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA22046413  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25214829Effect of cigarette smoke condensate on gene promoter methylation in human lung cells. (2014)Lyn-Cook LTob Induc Dis