Gene: TOPBP1

11073
TOP2BP1
DNA topoisomerase II binding protein 1
protein-coding
3q22.1
Ensembl:ENSG00000163781 MIM:607760 Vega:OTTHUMG00000159773 UniprotKB:Q92547
NC_000003.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.292e-2 (AD)  2.637e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10935070chr3:133623144 (GRCh38.p7)T>C / T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARFGEF10.953
AVL90.95
CEP680.95
HEATR5B0.948
POLR2B0.944
ANAPC10.941
RC3H20.94
ARFGEF20.939
CEP1700.938
HECTD10.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.455
OR4F29-0.43
S100A1-0.429
EYA2-0.41
HMX1-0.392
HEY2-0.374
AQP5-0.373
S100A14-0.371
FOXJ1-0.371
PLA2G5-0.368

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TOPBP1 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TOPBP1 mRNA"25614096
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TOPBP1 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TOPBP1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TOPBP1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TOPBP1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TOPBP1 mRNA"25510870
D000082AcetaminophenAcetaminophen results in decreased expression of TOPBP1 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen results in increased expression of TOPBP1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of TOPBP1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of TOPBP1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TOPBP1 mRNA19770486
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of TOPBP1 mRNA"22863853
D001280AtrazineAtrazine results in increased expression of TOPBP1 mRNA25929836
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of TOPBP1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TOPBP1 mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TOPBP1 mRNA"19150397|2038263
D004958EstradiolEstradiol affects the expression of TOPBP1 mRNA15598610
C006780bisphenol Abisphenol A results in decreased expression of TOPBP1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of TOPBP1 mRNA26982218
C006780bisphenol Abisphenol A results in increased expression of TOPBP1 mRNA25181051
D002104CadmiumCadmium results in decreased expression of TOPBP1 mRNA21297354
D002220CarbamazepineCarbamazepine affects the expression of TOPBP1 mRNA25979313
C099555CD 437CD 437 results in decreased expression of TOPBP1 mRNA12958071
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TOPBP1 mRNA23650126
D002737ChloropreneChloroprene results in increased expression of TOPBP1 mRNA23125180
D019327Copper SulfateCopper Sulfate results in decreased expression of TOPBP1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TOPBP1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of TOPBP1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of TOPBP1 mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of TOPBP1 mRNA21878529
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of TOPBP1 mRNA21878529
D016572CyclosporineCyclosporine results in decreased expression of TOPBP1 mRNA20106945|2556210
D003703DemecolcineDemecolcine results in decreased expression of TOPBP1 mRNA23649840
D015255IdarubicinDexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TOPBP1 mRNA]28973540
D015255IdarubicinIdarubicin results in decreased expression of TOPBP1 mRNA28973540
D064730DexrazoxaneDexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TOPBP1 mRNA]28973540
D064730DexrazoxaneDexrazoxane results in decreased expression of TOPBP1 mRNA28973540
D002945CisplatinCisplatin results in increased expression of TOPBP1 mRNA21151649
D004026DieldrinDieldrin results in increased expression of TOPBP1 mRNA20438755
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TOPBP1 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TOPBP1 mRNA]17854601
D002117CalcitriolCalcitriol results in decreased expression of TOPBP1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of TOPBP1 mRNA21592394
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of TOPBP1 mRNA27638505
D004317DoxorubicinDoxorubicin results in decreased expression of TOPBP1 mRNA27181935
D004317DoxorubicinFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of TOPBP1 mRNA]27181935
D005472FluorouracilTOPBP1 protein affects the susceptibility to Fluorouracil15548681
D062610Fungal PolysaccharidesFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of TOPBP1 mRNA]27181935
D017313FenretinideFenretinide results in increased expression of TOPBP1 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in decreased expression of TOPBP1 mRNA17183730
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of TOPBP1 mRNA19376150
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TOPBP1 mRNA21641980
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TOPBP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TOPBP1 mRNA"25554681
D009538NicotineNicotine results in increased expression of TOPBP1 mRNA16949557
C025589ochratoxin Aochratoxin A results in decreased acetylation of TOPBP1 promoter29098329
C025589ochratoxin A[ochratoxin A results in decreased acetylation of TOPBP1 promoter] which results in decreased expression of TOPBP1 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in decreased expression of TOPBP1 mRNA29098329
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TOPBP1 mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TOPBP1 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of TOPBP1 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of TOPBP1 mRNA23091169
C030090phosphoramide mustardphosphoramide mustard results in increased expression of TOPBP1 mRNA26708502
C006253pirinixic acidpirinixic acid results in increased expression of TOPBP1 mRNA18301758
D010894PiroxicamPiroxicam results in decreased expression of TOPBP1 mRNA21858171
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of TOPBP1 mRNA19167446
C059514resveratrolresveratrol results in decreased expression of TOPBP1 mRNA15767336
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TOPBP1 mRNA21641980
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of TOPBP1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of TOPBP1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TOPBP1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TOPBP1 mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TOPBP1 mRNA22298810
C009495titanium dioxidetitanium dioxide results in increased expression of TOPBP1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TOPBP1 mRNA25729387
C012589trichostatin Atrichostatin A affects the expression of TOPBP1 mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TOPBP1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TOPBP1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of TOPBP1 mRNA19140230
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in decreased expression of TOPBP1 mRNA17183730
D014640VancomycinVancomycin results in decreased expression of TOPBP1 mRNA18930951
D014750VincristineVincristine results in decreased expression of TOPBP1 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of TOPBP1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI11934899  12773567  14576432  17006541  17887956  18923429  
20080954  21659603  
GO:0008022protein C-terminus binding-TAS9461304  
GO:0042802identical protein binding-IPI17006541  
GO ID GO Term Qualifier Evidence PubMed
GO:0006259DNA metabolic process-TAS9461304  
GO:0006281DNA repair-NAS12773567  
GO:0006974cellular response to DNA damage stimulus-IDA12773567  
GO:0010212response to ionizing radiation-IDA12773567  
GO:0033314mitotic DNA replication checkpoint-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000794condensed nuclear chromosome-IEA-  
GO:0000922spindle pole-IEA-  
GO:0001673male germ cell nucleus-IEA-  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005694chromosome-IDA21659603  
GO:0005737cytoplasm-IEA-  
GO:0005815microtubule organizing center-IEA-  
GO:0015629actin cytoskeleton-IDA-  
GO:0016604nuclear body-IDA-  
GO:0016605PML body-IDA12773567  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5685938HDR through Single Strand Annealing (SSA)TAS
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693579Homologous DNA Pairing and Strand ExchangeTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchangeTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26003539Correlation between BRCA1 and TopBP1 protein expression and clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy. (2015 Jul)Wang LRCancer Chemother Pharmacol
23908141Interaction of polymorphisms in mitotic regulator genes with cigarette smoking and pancreatic cancer risk. (2013 Nov)Jang JHMol Carcinog