Gene: CHD4

1108
CHD-4|Mi-2b|Mi2-BETA|SIHIWES
chromodomain helicase DNA binding protein 4
protein-coding
12p13.31
Ensembl:ENSG00000111642 MIM:603277 Vega:OTTHUMG00000169164 UniprotKB:Q14839
NG_052823.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.985e-1 (AD)  2.868e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HNRNPUL10.915
HNRNPU0.903
IST10.891
BAZ1B0.889
SRSF10.888
RAF10.886
SRSF40.882
HNRNPA2B10.881
LSM14A0.879
CTNNA10.877

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.818
OR4F5-0.811
C17orf112-0.134
MUC7-0.128
PIP-0.127
STATH-0.124
OR2A2-0.123
PRAMEF7-0.12
HMHB1-0.119
ZG16B-0.117

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CHD4 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHD4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHD4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CHD4 mRNA21420995
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of CHD4 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CHD4 mRNA]17585979
D001151ArsenicArsenic results in decreased expression of CHD4 mRNA19654921
C517975AZD 6244AZD 6244 inhibits the reaction [Harmine results in increased phosphorylation of CHD4 protein]27805061
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of CHD4 mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CHD4 mRNA19770486|2222880
C044887beta-methylcholinebeta-methylcholine affects the expression of CHD4 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CHD4 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of CHD4 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of CHD4 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CHD4 mRNA28628672
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of CHD4 protein19552622
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased phosphorylation of CHD4 protein22174045
D020148Butyric AcidButyric Acid inhibits the reaction [CHD4 protein binds to OGT protein]27231347
D020148Butyric AcidButyric Acid inhibits the reaction [thiamet G results in increased O-linked glycosylation of CHD4 protein]27231347
D020148Butyric AcidButyric Acid results in decreased O-linked glycosylation of CHD4 protein27231347
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CHD4 mRNA26472689
D002509CephaloridineCephaloridine results in decreased expression of CHD4 mRNA18500788
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of CHD4 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CHD4 mRNA]17585979
D013759DronabinolDronabinol results in decreased expression of CHD4 mRNA18454173
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CHD4 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CHD4 mRNA28628672
D003976DiazinonDiazinon results in increased methylation of CHD4 gene22964155
C000944dicrotophosdicrotophos results in increased expression of CHD4 mRNA28302478
D004237DiuronDiuron results in decreased expression of CHD4 mRNA25152437
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CHD4 protein23301498
D000431EthanolEthanol affects the expression of CHD4 mRNA26730594
D005485FlutamideFlutamide results in decreased expression of CHD4 mRNA24793618
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of CHD4 mRNA22634610
D006247HarmineAZD 6244 inhibits the reaction [Harmine results in increased phosphorylation of CHD4 protein]27805061
D006247HarmineHarmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]27805061
D006247HarmineHarmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]27805061
D006247HarmineHarmine results in increased phosphorylation of CHD4 protein27805061
D006427Hemin[Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein]27231347
D006427Hemin[Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [thiamet G results in increased O-linked glycosylation of CHD4 protein]27231347
D006427Hemin[Hemin co-treated with hexamethylene bisacetamide] results in decreased O-linked glycosylation of CHD4 protein27231347
C014026hexamethylene bisacetamide[Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein]27231347
C014026hexamethylene bisacetamide[Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [thiamet G results in increased O-linked glycosylation of CHD4 protein]27231347
C014026hexamethylene bisacetamide[Hemin co-treated with hexamethylene bisacetamide] results in decreased O-linked glycosylation of CHD4 protein27231347
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CHD4 mRNA20044591
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of CHD4 mRNA19376150
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CHD4 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CHD4 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CHD4 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CHD4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CHD4 mRNA28628672
D007854LeadLead affects the expression of CHD4 mRNA28903495
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CHD4 mRNA26378955
D008694MethamphetamineMethamphetamine results in decreased methylation of CHD4 promoter26307267
D008694MethamphetamineMethamphetamine results in increased expression of CHD4 mRNA26307267
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CHD4 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHD4 mRNA"27188386
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CHD4 mRNA"20188158
C028007nickel monoxidenickel monoxide results in increased expression of CHD4 mRNA19167457
D052638Particulate MatterParticulate Matter results in increased expression of CHD4 mRNA28412507
D010416PentachlorophenolPentachlorophenol results in increased expression of CHD4 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CHD4 protein26879310
D010634PhenobarbitalPhenobarbital results in decreased expression of CHD4 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CHD4 mRNA19710929
C045950propiconazolepropiconazole results in decreased expression of CHD4 mRNA21278054
D012643SeleniumSelenium results in increased expression of CHD4 mRNA19244175
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CHD4 mRNA26378955
C004648testosterone enanthatetestosterone enanthate affects the expression of CHD4 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CHD4 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CHD4 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of CHD4 protein24648495
C572247thiamet GButyric Acid inhibits the reaction [thiamet G results in increased O-linked glycosylation of CHD4 protein]27231347
C572247thiamet G[Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [thiamet G results in increased O-linked glycosylation of CHD4 protein]27231347
C572247thiamet Gthiamet G promotes the reaction [CHD4 protein binds to HBG2 promoter]27231347
C572247thiamet Gthiamet G results in increased O-linked glycosylation of CHD4 protein27231347
D013849ThimerosalThimerosal results in decreased expression of CHD4 mRNA27188386
C483909torcetrapibtorcetrapib results in increased expression of CHD4 mRNA23228038
D014241TrichloroethyleneTrichloroethylene results in increased expression of CHD4 mRNA19448997
C025643vinclozolinvinclozolin results in decreased expression of CHD4 mRNA18042343
C111237vorinostatvorinostat results in decreased expression of CHD4 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA bindingcontributes_toHDA16217013  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingcontributes_toHDA16217013  
GO:0001103RNA polymerase II repressing transcription factor binding-IPI22926524  
GO:0003677DNA binding-TAS9326634  
GO:0004003ATP-dependent DNA helicase activity-TAS9326634  
GO:0004407histone deacetylase activity-TAS-  
GO:0005515protein binding-IPI9804427  10220385  10228159  17314511  19644445  20693977  
21258344  22720776  23752268  25150861  26859351  28977666  
GO:0005524ATP binding-IEA-  
GO:0008270zinc ion binding-TAS7560064  
GO:0031492nucleosomal DNA bindingcontributes_toHDA16217013  
GO:0042826histone deacetylase binding-IPI27616479  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-TAS9326634  
GO:0016575histone deacetylation-IEA-  
GO:0032508DNA duplex unwinding-IEA-  
GO:0043044ATP-dependent chromatin remodeling-HDA16217013  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-HDA16217013  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA22720776  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA17626165  
GO:0005813centrosome-IDA17626165  
GO:0016020membrane-HDA19946888  
GO:0016581NuRD complex-IDA19644445  
GO:0032991protein-containing complex-HDA16217013  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1257604PIP3 activates AKT signalingIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-212165Epigenetic regulation of gene expressionIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3214815HDACs deacetylate histonesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-427389ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionIEA
R-HSA-4839726Chromatin organizationTAS
R-HSA-5250913Positive epigenetic regulation of rRNA expressionIEA
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-6804758Regulation of TP53 Activity through AcetylationTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-6807070PTEN RegulationIEA
R-HSA-73762RNA Polymerase I Transcription InitiationTAS
R-HSA-73854RNA Polymerase I Promoter ClearanceTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73864RNA Polymerase I TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-8943724Regulation of PTEN gene transcriptionTAS
R-HSA-8943724Regulation of PTEN gene transcriptionIEA
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006925Intracellular signaling by second messengersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25407497Association of the chromodomain helicase DNA-binding protein 4 (CHD4) missense variation p.D140E with cancer: potential interaction with smoking. (2015 Feb)Yamada MGenes Chromosomes Cancer