Gene: ADAMTS13

11093
ADAM-TS13|ADAMTS-13|C9orf8|VWFCP|vWF-CP
ADAM metallopeptidase with thrombospondin type 1 motif 13
protein-coding
9q34.2
Ensembl:ENSG00000160323 MIM:604134 Vega:OTTHUMG00000020876 UniprotKB:Q76LX8
NG_011934.2
PubMed
0   ANCO-SNPs
ND|AD
5   
4.805e-2 (AD)  5.606e-1 (ND)   (Frontal_Cortex)
5.612e-2 (AD)  4.423e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCNN1D0.916
CORO60.899
CUL90.898
NEIL10.887
IFT1720.886
HOOK20.883
RTEL10.882
PTCH20.882
PKD10.88
TSC20.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAS2-0.448
OR4F5-0.445
C9orf135-0.443
AGTR1-0.436
IGF2BP2-0.436
ZNF114-0.424
PABPC4L-0.421
OR4F29-0.415
CD8B-0.414
KIAA0040-0.41

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB12872Vonicog AlfaBiotechDrug109319-16-6Approved|InvestigationalEnzyme
DB13133Von Willebrand Factor HumanBiotechDrug109319-16-6Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ADAMTS13 mRNA"25614096
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ADAMTS13 mRNA22100608
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of ADAMTS13 mRNA25690898
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of ADAMTS13 gene25435355
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased activity of ADAMTS13 protein16689760
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ADAMTS13 protein16689760
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ADAMTS13 mRNA27392435
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in decreased expression of ADAMTS13 mRNA20705681
D004128DimethylnitrosamineDimethylnitrosamine results in decreased activity of ADAMTS13 protein17383642
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ADAMTS13 mRNA27392435
C544151jinfukangjinfukang results in increased expression of ADAMTS13 mRNA27392435
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 affects the expression of ADAMTS13 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ADAMTS13 mRNA21878173
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ADAMTS13 protein21878173
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of ADAMTS13 mRNA16966085
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ADAMTS13 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ADAMTS13 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ADAMTS13 mRNA"25620056
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in decreased expression of ADAMTS13 mRNA20705681
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ADAMTS13 mRNA25895662
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ADAMTS13 mRNA"26179874

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-IEA-  
GO:0005178integrin binding-TAS11557746  
GO:0005509calcium ion binding-TAS11557746  
GO:0005515protein binding-IPI12775718  16221672  18492805  25512528  
GO:0008237metallopeptidase activity-TAS11557746  
GO:0008270zinc ion binding-TAS11557746  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IDA11535495  
GO:0007160cell-matrix adhesion-NAS11557746  
GO:0007229integrin-mediated signaling pathway-NAS11557746  
GO:0009100glycoprotein metabolic process-NAS11557746  
GO:0009636response to toxic substance-IEA-  
GO:0014075response to amine-IEA-  
GO:0016485protein processing-TAS11557746  
GO:0030168platelet activation-NAS11557746  
GO:0035864response to potassium ion-IEA-  
GO:0043171peptide catabolic process-IDA11535495  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0071346cellular response to interferon-gamma-IEA-  
GO:0071353cellular response to interleukin-4-IEA-  
GO:0071356cellular response to tumor necrosis factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0009986cell surface-NAS11557746  
GO:0031012extracellular matrix-TAS11557746  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5173214O-glycosylation of TSR domain-containing proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17606444Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports. (2007 Jul)Swisher KKHaematologica
27067884Hemostatic Markers and Long-Term Risk of Intracerebral Hemorrhage in Postmenopausal Women. (2016 Jul)Lee JMJ Stroke Cerebrovasc Dis
29296746Genetic variants in ADAMTS13 as well as smoking are major determinants of plasma ADAMTS13 levels. (2017 Jun 27)Ma QBlood Adv
27259465The unexpected beneficial role of smoking in preeclampsia. (2016 Aug 1)Alpoim PNClin Chim Acta
29669506Mutations and Common Polymorphisms in ADAMTS13 and vWF Genes Responsible for Increasing Risk of Thrombosis. (2018 Apr 18)Haybar HCardiovasc Hematol Disord Drug Targets