Gene: ADAMTS5

11096
ADAM-TS 11|ADAM-TS 5|ADAM-TS5|ADAMTS-11|ADAMTS-5|ADAMTS11|ADMP-2
ADAM metallopeptidase with thrombospondin type 1 motif 5
protein-coding
21q21.3
Ensembl:ENSG00000154736 MIM:605007 Vega:OTTHUMG00000078686 UniprotKB:Q9UNA0
NC_000021.9
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.153e-1 (AD)  1.966e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IGF10.831
HAPLN10.767
NPR30.766
LGI20.745
PLD50.722
ZNF385D0.715
PTHLH0.707
KIT0.697
NXPH10.697
MYO5B0.696

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIF19-0.485
ATOH8-0.474
NPIPB6-0.45
PLIN2-0.443
NRN1L-0.441
SLC52A3-0.436
FXYD3-0.435
ANGPTL4-0.433
ITGB4-0.426
ROM1-0.422

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03880BatimastatSmall Molecule130370-60-4ExperimentalTarget
DB06837(2R)-N~4~-hydroxy-2-(3-hydroxybenzyl)-N~1~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamideSmall MoleculeExperimentalTarget
DB06945N-hydroxy-4-({4-[4-(trifluoromethyl)phenoxy]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamideSmall Molecule-ExperimentalTarget
ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of ADAMTS5 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ADAMTS5 mRNA19933214
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of ADAMTS5 mRNA]"19414516
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of ADAMTS5 mRNA25088246
C1088922-phenylcyclopropanecarboxylic acid2-phenylcyclopropanecarboxylic acid analog binds to and results in decreased activity of ADAMTS5 protein21417219
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ADAMTS5 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADAMTS5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADAMTS5 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ADAMTS5 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ADAMTS5 mRNA23630614
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ADAMTS5 mRNA21298039
D001151ArsenicArsenic affects the methylation of ADAMTS5 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of ADAMTS5 mRNA25258189
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ADAMTS5 mRNA"24160326
C547126AZM551248AZM551248 results in increased expression of ADAMTS5 mRNA22323515
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ADAMTS5 mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of ADAMTS5 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of ADAMTS5 protein28285737
C006780bisphenol ASodium Selenite inhibits the reaction [bisphenol A results in decreased expression of ADAMTS5 protein]28285737
D002220CarbamazepineCarbamazepine affects the expression of ADAMTS5 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ADAMTS5 mRNA17484886
D002737ChloropreneChloroprene results in decreased expression of ADAMTS5 mRNA23125180
D002809Chondroitin Sulfates[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of ADAMTS5 mRNA17605605
D002857ChromiumChromium results in increased expression of ADAMTS5 mRNA21437242
D000069439DasatinibDasatinib results in increased expression of ADAMTS5 mRNA20579391
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in decreased expression of ADAMTS5 mRNA20705681
D004041Dietary FatsDietary Fats results in increased expression of ADAMTS5 mRNA18042831
D004237DiuronDiuron results in decreased expression of ADAMTS5 mRNA25152437
D004317DoxorubicinDoxorubicin results in decreased expression of ADAMTS5 mRNA16404146
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of ADAMTS5 mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ADAMTS5 mRNA22079256
C024565ethylene dichlorideethylene dichloride results in decreased expression of ADAMTS5 mRNA28189721
C540355fenamidonefenamidone results in increased expression of ADAMTS5 mRNA27029645
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of ADAMTS5 mRNA28329830
D004397FonofosFonofos results in increased methylation of ADAMTS5 promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of ADAMTS5 mRNA28937961
C039281furanfuran results in increased expression of ADAMTS5 mRNA27387713
D005944Glucosamine[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of ADAMTS5 mRNA17605605
D005944GlucosamineGlucosamine analog results in decreased expression of ADAMTS5 mRNA16300972
D005944GlucosamineGlucosamine results in decreased cleavage of and results in decreased activity of ADAMTS5 protein alternative form19909832
C065632glucosamine 3-O-sulfateglucosamine 3-O-sulfate results in decreased expression of ADAMTS5 mRNA16300972
C412815GW 4064GW 4064 results in decreased expression of ADAMTS5 mRNA26655953
D017313FenretinideFenretinide results in decreased expression of ADAMTS5 mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ADAMTS5 mRNA24796395
D007854LeadLead affects the expression of ADAMTS5 mRNA28903495
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ADAMTS5 mRNA26378955
C008322mannosaminemannosamine results in decreased cleavage of ADAMTS5 protein alternative form19909832
D008727MethotrexateMethotrexate affects the expression of ADAMTS5 mRNA18502557
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ADAMTS5 mRNA"25554681
D009532NickelNickel results in increased expression of ADAMTS5 mRNA24768652|2558310
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ADAMTS5 mRNA25729387
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in decreased expression of ADAMTS5 mRNA20705681
D000073878Palm OilPalm Oil results in increased expression of ADAMTS5 mRNA18042831
D010278ParathionParathion results in increased methylation of ADAMTS5 promoter22847954
D052638Particulate MatterParticulate Matter results in decreased expression of ADAMTS5 mRNA23085030
D010634PhenobarbitalPhenobarbital affects the expression of ADAMTS5 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADAMTS5 mRNA"27188386
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ADAMTS5 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ADAMTS5 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ADAMTS5 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of ADAMTS5 mRNA23012394
D011441PropylthiouracilPropylthiouracil results in increased expression of ADAMTS5 mRNA24780913
D012643SeleniumSelenium results in decreased expression of ADAMTS5 mRNA19244175
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of ADAMTS5 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ADAMTS5 mRNA23221170
C017947sodium arsenitesodium arsenite results in decreased expression of ADAMTS5 mRNA25493608
D018038Sodium SeleniteSodium Selenite inhibits the reaction [bisphenol A results in decreased expression of ADAMTS5 protein]28285737
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ADAMTS5 mRNA26378955
D013605T-2 ToxinT-2 Toxin results in increased expression of ADAMTS5 mRNA18196609
D013605T-2 ToxinT-2 Toxin results in increased expression of ADAMTS5 mRNA22800716
C012568terbufosterbufos results in increased methylation of ADAMTS5 promoter22847954
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of ADAMTS5 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADAMTS5 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADAMTS5 mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADAMTS5 mRNA19933214
C009495titanium dioxidetitanium dioxide results in decreased expression of ADAMTS5 mRNA23557971|2776080
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ADAMTS5 mRNA25729387
D019772TopotecanTopotecan results in increased expression of ADAMTS5 mRNA25729387
D014212TretinoinTretinoin results in increased expression of ADAMTS5 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of ADAMTS5 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of ADAMTS5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ADAMTS5 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of ADAMTS5 mRNA24935251|2800136
D014810Vitamin EVitamin E results in decreased expression of ADAMTS5 mRNA19244175
C111237vorinostatvorinostat results in increased expression of ADAMTS5 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-TAS-  
GO:0005178integrin binding-TAS10438522  
GO:0005515protein binding-IPI22406378  
GO:0008201heparin binding-IEA-  
GO:0008237metallopeptidase activity-TAS10438522  
GO:0008270zinc ion binding-IEA-  
GO:0050840extracellular matrix binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0022617extracellular matrix disassembly-TAS-  
GO:0042742defense response to bacterium-IEA-  
GO:0044691tooth eruption-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0031012extracellular matrix-TAS10438522  
GO:0062023collagen-containing extracellular matrix-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1643685DiseaseTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5173214O-glycosylation of TSR domain-containing proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28570296ADAMTS5 Deficiency Protects Mice From Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration. (2017 Oct 15)Ngo KSpine (Phila Pa 1976)
28583914Association between COL11A1 (rs1337185) and ADAMTS5 (rs162509) gene polymorphisms and lumbar spine pathologies in Chinese Han population: an observational study. (2017 Jun 4)Jiang HBMJ Open