Gene: PRSS23

11098
SIG13|SPUVE|ZSIG13
serine protease 23
protein-coding
11q14.2
Ensembl:ENSG00000150687 Vega:OTTHUMG00000167226 UniprotKB:O95084
NC_000011.10
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.824e-1 (AD)  5.744e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23351584chr11:86512100PRSS237.560e-10Maternal smoking in pregnancy27040690
cg04660191chr11:86519158PRSS237.460e-9Maternal smoking in pregnancy27040690
cg23351584chr11:86512100PRSS235.960e-13Maternal smoking in pregnancy27040690
cg04660191chr11:86519158PRSS231.270e-9Maternal smoking in pregnancy27040690
cg23351584chr11:86512100PRSS231.400e-13Maternal smoking in pregnancy27040690
cg11660018chr11:86510915PRSS234.100e-25Smoking27651444
cg23351584chr11:86512100PRSS232.600e-19Smoking27651444
cg23771366chr11:86510998PRSS237.500e-18Smoking27651444
cg11660018chr11:86510915PRSS235.080e-20Tobacco smoking28225026
cg23771366chr11:86510998PRSS234.270e-15Tobacco smoking28225026
cg23351584chr11:86512100PRSS233.880e-9Tobacco smoking28225026
cg11660018chr11:86510915PRSS231.180e-26Smoking28686328
cg23771366chr11:86510998PRSS231.960e-17Smoking28686328
cg23351584chr11:86512100PRSS238.080e-12Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DAB20.769
KCTD120.768
ARHGAP180.746
FBLN50.737
NOD10.735
HSPG20.734
ADPRH0.728
SVIL0.725
CAV20.722
FGD50.718

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BTBD17-0.344
ARSF-0.336
HES5-0.326
NEU4-0.303
EPHB1-0.299
REN-0.298
HPSE2-0.294
ZNF98-0.277
RLBP1-0.276
ASPDH-0.272

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of PRSS23 mRNA"26377693
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRSS23 mRNA"25510870
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of PRSS23 mRNA"23384675
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"ESR1 protein inhibits the reaction [2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of PRSS23 mRNA]"23384675
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PRSS23 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of PRSS23 mRNA"19167446
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PRSS23 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRSS23 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRSS23 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRSS23 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRSS23 mRNA"25510870
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of PRSS23 mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C496492abrineabrine results in decreased expression of PRSS23 mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of PRSS23 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PRSS23 protein20106945
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of PRSS23 mRNA"18687144
D001280AtrazineAtrazine results in decreased expression of PRSS23 mRNA25929836
C487081belinostatbelinostat results in decreased expression of PRSS23 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PRSS23 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PRSS23 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PRSS23 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PRSS23 mRNA20106945|2187194
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PRSS23 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PRSS23 mRNA22228805|2261060
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of PRSS23 mRNA]24758408
D004958EstradiolESR1 protein inhibits the reaction [Estradiol results in increased expression of PRSS23 mRNA]23384675
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PRSS23 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of PRSS23 mRNA19167446|2301914
D004958EstradiolEstradiol results in increased expression of PRSS23 mRNA15913882|1961957
D004958Estradiolmethoxyacetic acid inhibits the reaction [Estradiol results in increased expression of PRSS23 mRNA]20049119
D001622BetaineBetaine results in increased expression of PRSS23 mRNA26391144
C006780bisphenol Abisphenol A affects the expression of PRSS23 mRNA20170705
C006780bisphenol Abisphenol A analog results in increased expression of PRSS23 mRNA23384675
C006780bisphenol Abisphenol A results in increased expression of PRSS23 mRNA22494775|2338467
C006780bisphenol AESR1 protein affects the reaction [bisphenol A results in increased expression of PRSS23 mRNA]23384675
C006780bisphenol AESR1 protein inhibits the reaction [bisphenol A analog results in increased expression of PRSS23 mRNA]23384675
C006780bisphenol Abisphenol A results in decreased expression of PRSS23 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of PRSS23 mRNA22079614
D002065BuspironeBuspirone results in decreased expression of PRSS23 mRNA24136188
C028031cadmium acetatecadmium acetate results in decreased expression of PRSS23 mRNA18155341
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of PRSS23 mRNA]16221973
D002220CarbamazepineCarbamazepine affects the expression of PRSS23 mRNA25979313
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of PRSS23 mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PRSS23 mRNA20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PRSS23 mRNA27858113
D002996ClomipheneClomiphene results in decreased expression of PRSS23 mRNA26865669
D003033Coal TarCoal Tar results in increased expression of PRSS23 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of PRSS23 mRNA19320972|1937684
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of PRSS23 mRNA20971185
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PRSS23 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of PRSS23 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of PRSS23 mRNA19167446
C030973cupric oxidecupric oxide results in decreased expression of PRSS23 mRNA22077320
D003471CuprizoneCuprizone results in increased expression of PRSS23 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of PRSS23 mRNA20106945|2798913
C089595cylindrospermopsincylindrospermopsin results in increased expression of PRSS23 mRNA24921660
C004742daidzeindaidzein results in increased expression of PRSS23 mRNA23384675
C004742daidzeinESR1 protein inhibits the reaction [daidzein results in increased expression of PRSS23 mRNA]23384675
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PRSS23 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of PRSS23 mRNA22023808
D004041Dietary FatsDietary Fats results in decreased expression of PRSS23 mRNA18457598
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of PRSS23 mRNA25374375
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of PRSS23 promoter25374375
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PRSS23 mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PRSS23 mRNA26865669
D002117CalcitriolCalcitriol results in increased expression of PRSS23 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of PRSS23 mRNA21592394
D004237DiuronDiuron results in decreased expression of PRSS23 mRNA21551480|2515243
C118739entinostatentinostat results in decreased expression of PRSS23 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PRSS23 mRNA22079256
D004970EstroneEstrone results in increased expression of PRSS23 mRNA26865669
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PRSS23 mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PRSS23 mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PRSS23 mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PRSS23 mRNA17557909
D008656MestranolMestranol results in increased expression of PRSS23 mRNA26865669
D015025ZearalenoneZearalenone results in increased expression of PRSS23 mRNA22494775
C540355fenamidonefenamidone results in increased expression of PRSS23 mRNA27029645
D005473FluoxetineFluoxetine results in decreased expression of PRSS23 mRNA17033635
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PRSS23 mRNA20938992
D004397FonofosFonofos results in increased methylation of PRSS23 promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of PRSS23 mRNA27664576
C070081fulvestrantfulvestrant results in decreased expression of PRSS23 mRNA26865669
D019833GenisteinESR1 protein inhibits the reaction [Genistein results in increased expression of PRSS23 mRNA]23384675
D019833GenisteinGenistein results in decreased expression of PRSS23 mRNA26865667
D019833GenisteinGenistein results in increased expression of PRSS23 mRNA23384675|2686566
D005897GlafenineGlafenine results in decreased expression of PRSS23 mRNA24136188
D006589HexestrolHexestrol results in increased expression of PRSS23 mRNA26865669
D017313FenretinideFenretinide results in decreased expression of PRSS23 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of PRSS23 mRNA26191083
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PRSS23 mRNA24796395
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PRSS23 mRNA26644586
C045463leflunomideleflunomide results in increased expression of PRSS23 mRNA19751817
C042720mercuric bromidemercuric bromide results in decreased expression of PRSS23 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PRSS23 mRNA20938992
C013598methoxyacetic acidmethoxyacetic acid inhibits the reaction [Estradiol results in increased expression of PRSS23 mRNA]20049119
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PRSS23 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PRSS23 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PRSS23 mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of PRSS23 mRNA24136188
D009532NickelNickel results in increased expression of PRSS23 mRNA24768652|2558310
C012655nimesulidenimesulide results in decreased expression of PRSS23 mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of PRSS23 mRNA17616710
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of PRSS23 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of PRSS23 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PRSS23 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of PRSS23 mRNA25729387
C500026palbociclibpalbociclib results in increased expression of PRSS23 mRNA22869556
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of PRSS23 mRNA26272509
D010278ParathionParathion results in increased methylation of PRSS23 promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRSS23 mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the expression of PRSS23 mRNA19159669
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of PRSS23 mRNA25374375
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of PRSS23 promoter25374375
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PRSS23 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PRSS23 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of PRSS23 mRNA18445702
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PRSS23 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PRSS23 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of PRSS23 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of PRSS23 mRNA23018184
D011374ProgesteroneProgesterone results in decreased expression of PRSS23 mRNA21273126
D011374ProgesteroneProgesterone results in increased expression of PRSS23 mRNA21795739
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PRSS23 mRNA27029645
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of PRSS23 mRNA26865669
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of PRSS23 mRNA19167446
C059514resveratrolresveratrol results in decreased expression of PRSS23 mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PRSS23 mRNA25895662
D012834SilverSilver results in decreased expression of PRSS23 mRNA27131904
D053260SootSoot results in decreased expression of PRSS23 mRNA22461453
C025462sulindac sulfidesulindac sulfide results in decreased expression of PRSS23 mRNA12734198
C012568terbufosterbufos results in increased methylation of PRSS23 promoter22847954
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of PRSS23 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of PRSS23 mRNA21592394
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of PRSS23 mRNA25172293
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PRSS23 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRSS23 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRSS23 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PRSS23 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRSS23 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRSS23 mRNA22298810
D019284ThapsigarginThapsigargin results in decreased expression of PRSS23 protein24648495
C009495titanium dioxidetitanium dioxide results in decreased expression of PRSS23 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PRSS23 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of PRSS23 gene26756918
C024746tobacco tartobacco tar results in decreased expression of PRSS23 mRNA19559774
D014050TolueneToluene results in increased expression of PRSS23 mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PRSS23 mRNA25729387
D019772TopotecanTopotecan results in increased expression of PRSS23 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of PRSS23 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PRSS23 mRNA24935251|2627250
C080163trovafloxacintrovafloxacin results in decreased expression of PRSS23 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of PRSS23 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of PRSS23 mRNA19101580
D014640VancomycinVancomycin results in decreased expression of PRSS23 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PRSS23 gene25560391
C025643vinclozolinvinclozolin affects the expression of PRSS23 mRNA19015723
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRSS23 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of PRSS23 mRNA26272509
C088658zoledronic acidzoledronic acid results in decreased expression of PRSS23 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25424692Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation. (2014 Oct)Tsaprouni LGEpigenetics