Gene: ADCY5

111
AC5|FDFM
adenylate cyclase 5
protein-coding
3q21.1
Ensembl:ENSG00000173175 MIM:600293 Vega:OTTHUMG00000159517 UniprotKB:O95622
NG_033882.1
PubMed
0   ANCO-SNPs
OD|ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.272e-1 (AD)  2.496e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PIK3R20.899
CHD30.898
HCN20.895
AGAP20.892
APBA10.89
SLC4A30.887
ULK10.886
PPP1R16B0.885
SBF10.882
CBX70.881

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.548
OR4F29-0.511
IL18RAP-0.47
CST7-0.456
TFPI2-0.452
FFAR2-0.433
PDZK1IP1-0.431
KCNJ15-0.425
WEE1-0.417
S100A12-0.415

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02587ColforsinSmall Molecule66575-29-9Experimental|InvestigationalTarget
DB068432',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATESmall MoleculeExperimentalTarget
DB09121AurothioglucoseSmall Molecule12192-57-3Approved|WithdrawnTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ADCY5 mRNA"19114083
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosineADCY5 protein results in increased susceptibility to 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine12223546
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosineADCY5 protein results in increased susceptibility to [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine co-treated with Quinpirole]12223546
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of ADCY5 mRNA"23829299
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ADCY5 mRNA"12376462
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of ADCY5 mRNA"26186136
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of ADCY5 mRNA"27567155
D000109AcetylcholineADCY5 protein results in increased susceptibility to Acetylcholine12869393
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ADCY5 mRNA"23917077
D001285AtropineADCY5 protein results in increased susceptibility to Atropine12869393
C547126AZM551248AZM551248 results in decreased expression of ADCY5 mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ADCY5 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADCY5 mRNA21839799
D004958EstradiolEstradiol results in increased expression of ADCY5 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of ADCY5 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of ADCY5 gene28505145
C006780bisphenol Abisphenol A results in increased expression of ADCY5 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of ADCY5 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ADCY5 mRNA21457566
D002110CaffeineCaffeine results in decreased expression of ADCY5 mRNA26367767
D002118CalciumCalcium results in decreased activity of ADCY5 protein12065575
D002118CalciumADCY5 protein results in increased susceptibility to Calcium12869393
D002217CarbacholADCY5 protein results in increased susceptibility to Carbachol12869393
D002220CarbamazepineCarbamazepine inhibits the reaction [Colforsin results in increased activity of ADCY5 protein]19922557
D002220CarbamazepineCarbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY5 protein]19922557
D002220CarbamazepineCarbamazepine results in decreased activity of ADCY5 protein19922557
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of ADCY5 mRNA18636392
D003024ClozapineADCY5 protein affects the susceptibility to Clozapine12223546
D003024ClozapineSCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine]12223546
D005576ColforsinADCY5 protein results in increased susceptibility to [Colforsin co-treated with Quinpirole]12223546
D005576ColforsinCarbamazepine inhibits the reaction [Colforsin results in increased activity of ADCY5 protein]19922557
D005576ColforsinColforsin results in increased activity of ADCY5 protein19922557
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of ADCY5 mRNA23640034
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ADCY5 mRNA21266533
C061532dihydrexidineADCY5 protein results in increased susceptibility to dihydrexidine12223546
C061532dihydrexidineADCY5 protein results in increased susceptibility to [dihydrexidine co-treated with Quinpirole]12223546
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ADCY5 mRNA"12376462
D000431EthanolEthanol results in decreased expression of ADCY5 mRNA20655511
D005557FormaldehydeFormaldehyde results in decreased expression of ADCY5 mRNA14756816
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of ADCY5 gene28505145
D006220HaloperidolADCY5 protein affects the susceptibility to Haloperidol12223546
D006220HaloperidolSCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Haloperidol]12223546
D017313FenretinideFenretinide results in decreased expression of ADCY5 mRNA28973697
D007545IsoproterenolADCY5 protein results in increased susceptibility to Isoproterenol12869393|2353636
D007545Isoproterenol[ADCY5 protein results in increased susceptibility to Isoproterenol] which results in decreased expression of SOD2 protein23536361
D007545IsoproterenolSOD2 protein inhibits the reaction [ADCY5 protein results in increased susceptibility to Isoproterenol]23536361
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ADCY5 mRNA21212295
D008070Lipopolysaccharides[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased expression of ADCY5 mRNA21212295
D008094LithiumLithium results in decreased activity of ADCY5 protein19922557
D008094LithiumMagnesium inhibits the reaction [Lithium results in decreased activity of ADCY5 protein]19922557
D008274MagnesiumMagnesium results in increased activity of ADCY5 protein12065575
D008274MagnesiumMagnesium inhibits the reaction [Lithium results in decreased activity of ADCY5 protein]19922557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ADCY5 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ADCY5 mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ADCY5 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ADCY5 mRNA"25554681
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ADCY5 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ADCY5 mRNA27935865
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of ADCY5 mRNA18636392
D010269ParaquatParaquat results in increased expression of ADCY5 mRNA17077588
C410127PCB 180PCB 180 results in increased expression of ADCY5 mRNA23829299
D010656PhenylephrineADCY5 protein results in increased susceptibility to Phenylephrine12869393
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ADCY5 mRNA27935865
D011374ProgesteroneProgesterone results in increased expression of ADCY5 mRNA20726854
D011441PropylthiouracilPropylthiouracil results in decreased expression of ADCY5 mRNA24780913
D019257QuinpiroleADCY5 protein results in increased susceptibility to [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine co-treated with Quinpirole]12223546
D019257QuinpiroleADCY5 protein results in increased susceptibility to [Colforsin co-treated with Quinpirole]12223546
D019257QuinpiroleADCY5 protein results in increased susceptibility to [dihydrexidine co-treated with Quinpirole]12223546
D019257QuinpiroleADCY5 protein results in increased susceptibility to [Quinpirole co-treated with VIP protein]12223546
C534628SCH 23390SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine]12223546
C534628SCH 23390SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Haloperidol]12223546
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ADCY5 mRNA25895662
C071262SK&F 82958Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY5 protein]19922557
C071262SK&F 82958[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY5 protein19922557
D053260SootSoot results in decreased expression of ADCY5 mRNA26551751
D013469SulpirideADCY5 protein results in increased susceptibility to Sulpiride12223546
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased expression of ADCY5 mRNA21212295
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ADCY5 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADCY5 mRNA19933214|2121229
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"ADCY5 protein results in increased susceptibility to 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"12223546
D014212TretinoinTretinoin results in increased expression of ADCY5 mRNA23830798
D014635Valproic AcidValproic Acid results in increased methylation of ADCY5 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ADCY5 mRNA23665938
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ADCY5 gene25560391
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ADCY5 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004016adenylate cyclase activity-IDA15385642  24700542  
GO:0004016adenylate cyclase activity-IMP24740569  
GO:0005524ATP binding-IEA-  
GO:0008179adenylate cyclase binding-ISS-  
GO:0046872metal ion binding-IEA-  
GO:0046982protein heterodimerization activity-ISS-  
GO:0097110scaffold protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001973adenosine receptor signaling pathway-IEA-  
GO:0003091renal water homeostasis-TAS-  
GO:0006171cAMP biosynthetic process-IBA21873635  
GO:0006171cAMP biosynthetic process-IDA15385642  24700542  
GO:0006171cAMP biosynthetic process-IMP24740569  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IMP24700542  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-TAS-  
GO:0007191adenylate cyclase-activating dopamine receptor signaling pathway-IEA-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-TAS-  
GO:0007195adenylate cyclase-inhibiting dopamine receptor signaling pathway-IEA-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IMP24740569  
GO:0007626locomotory behavior-IEA-  
GO:0019933cAMP-mediated signaling-IBA21873635  
GO:0050885neuromuscular process controlling balance-IEA-  
GO:0061178regulation of insulin secretion involved in cellular response to glucose stimulus-IMP24740569  
GO:0071377cellular response to glucagon stimulus-TAS-  
GO:1904322cellular response to forskolin-IDA15385642  24700542  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0005929cilium-ISS-  
GO:0016021integral component of membrane-IDA15385642  
GO:0045111intermediate filament cytoskeleton-IDA-  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa04062Chemokine signaling pathway
hsa04114Oocyte meiosis
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04916Melanogenesis
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04976Bile secretion
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-111885Opioid SignallingTAS
R-HSA-111885Opioid SignallingIEA
R-HSA-111931PKA-mediated phosphorylation of CREBTAS
R-HSA-111933Calmodulin induced eventsTAS
R-HSA-111996Ca-dependent eventsTAS
R-HSA-111997CaM pathwayTAS
R-HSA-112040G-protein mediated eventsTAS
R-HSA-112040G-protein mediated eventsIEA
R-HSA-112043PLC beta mediated eventsTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionIEA
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112315Transmission across Chemical SynapsesIEA
R-HSA-112316Neuronal SystemTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-1430728MetabolismTAS
R-HSA-1489509DAG and IP3 signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-163359Glucagon signaling in metabolic regulationTAS
R-HSA-163615PKA activationTAS
R-HSA-163685Integration of energy metabolismTAS
R-HSA-164378PKA activation in glucagon signallingTAS
R-HSA-170660Adenylate cyclase activating pathwayTAS
R-HSA-170670Adenylate cyclase inhibitory pathwayTAS
R-HSA-170670Adenylate cyclase inhibitory pathwayIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretionTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-400042Adrenaline,noradrenaline inhibits insulin secretionTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-418555G alpha (s) signalling eventsIEA
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-418597G alpha (z) signalling eventsIEA
R-HSA-418597G alpha (z) signalling eventsTAS
R-HSA-422356Regulation of insulin secretionTAS
R-HSA-432040Vasopressin regulates renal water homeostasis via AquaporinsTAS
R-HSA-445717Aquaporin-mediated transportTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5610787Hedgehog 'off' stateTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-977443GABA receptor activationTAS
R-HSA-977443GABA receptor activationIEA
R-HSA-977444GABA B receptor activationTAS
R-HSA-977444GABA B receptor activationIEA
R-HSA-991365Activation of GABAB receptorsTAS
R-HSA-991365Activation of GABAB receptorsIEA
R-HSA-997269Inhibition of adenylate cyclase pathwayTAS
R-HSA-997269Inhibition of adenylate cyclase pathwayIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21885063Replication of a genome-wide association study of birth weight in preterm neonates. (2012 Jan)Ryckman KKJ Pediatr
20372150Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. (2010 May)Freathy RMNat Genet
23278386Genetic markers of comorbid depression and alcoholism in women. (2013 Jun)Procopio DOAlcohol Clin Exp Res
23202124New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. (2013 Jan)Horikoshi MNat Genet
25025380Effects of an oxycodone conjugate vaccine on oxycodone self-administration and oxycodone-induced brain gene expression in rats. (2014)Pravetoni MPLoS One