| C067795 | 10-decarbamoylmitomycin C | 10-decarbamoylmitomycin C results in decreased expression of and results in decreased stability of CHEK1 protein | 20536192 |
| C067795 | 10-decarbamoylmitomycin C | 10-decarbamoylmitomycin C results in decreased expression of CHEK1 mRNA | 20536192 |
| C067795 | 10-decarbamoylmitomycin C | 10-decarbamoylmitomycin C results in decreased expression of CHEK1 protein | 17530733 |
| C067795 | 10-decarbamoylmitomycin C | carbobenzoxy-leucyl-leucyl-norvalinal inhibits the reaction [10-decarbamoylmitomycin C results in decreased expression of CHEK1 protein] | 20536192 |
| C067795 | 10-decarbamoylmitomycin C | CHEK1 protein affects the susceptibility to 10-decarbamoylmitomycin C | 20536192 |
| C582286 | 1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea | 1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased phosphorylation of CHEK1 protein | 26208482 |
| C582286 | 1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased phosphorylation of CHEK1 protein] | 26208482 |
| C582286 | 1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea | "4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased phosphorylation of CHEK1 protein]" | 26208482 |
| C582286 | 1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea | MGMT mutant form promotes the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased phosphorylation of CHEK1 protein] | 26208482 |
| C028474 | 1,4-bis(2-(3,5-dichloropyridyloxy))benzene | "[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of CHEK1 mRNA" | 23626729 |
| C448659 | 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin | 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Doxorubicin results in increased phosphorylation of CHEK1 protein] | 17085670 |
| C448659 | 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin | 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin results in decreased expression of CHEK1 protein | 17085670 |
| C587734 | 2,3,5-trichloro-6-phenyl-(1,4)benzoquinone | "2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of CHEK1 protein" | 26451628 |
| C029497 | 2,3-bis(3'-hydroxybenzyl)butyrolactone | "2,3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of CHEK1 mRNA" | 19167446 |
| C029497 | 2,3-bis(3'-hydroxybenzyl)butyrolactone | "[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CHEK1 mRNA" | 19167446 |
| C036990 | 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline | "[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CHEK1 mRNA" | 23681119 |
| C031278 | 2-chloroethyl ethyl sulfide | 2-chloroethyl ethyl sulfide results in increased phosphorylation of CHEK1 protein | 20469912 |
| C031278 | 2-chloroethyl ethyl sulfide | 2-chloroethyl ethyl sulfide results in increased phosphorylation of CHEK1 protein | 20469912 |
| C070279 | 2'-cyano-2'-deoxyarabinofuranosylcytosine | 2'-cyano-2'-deoxyarabinofuranosylcytosine results in increased phosphorylation of and results in increased activity of CHEK1 protein | 16061671 |
| C511621 | 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide | 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of CHEK1 mRNA] | 28655636 |
| C511621 | 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide | 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of CHEK1 mRNA] | 28655636 |
| C495818 | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased phosphorylation of CHEK1 protein] | 26208482 |
| C495818 | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] | 22119920 |
| C495818 | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein] | 22403396 |
| C495818 | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [arsenic trioxide results in increased phosphorylation of CHEK1 protein] | 23337567 |
| C023035 | 3,4,5,3',4'-pentachlorobiphenyl | "3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CHEK1 mRNA" | 23196670 |
| C560580 | 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide | 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form] | 25269479 |
| C560580 | 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide | 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [NSC 724998 results in increased expression of CHEK1 protein modified form] | 25269479 |
| C532363 | 3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide | 3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide results in decreased activity of CHEK1 protein | 23897988 |
| C532363 | 3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide | 3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide results in decreased activity of CHEK1 protein | 21413798 |
| C017906 | 3-dinitrobenzene | 3-dinitrobenzene results in increased expression of CHEK1 mRNA | 22841810 |
| C025946 | 3-methyladenine | 3-methyladenine inhibits the reaction [BO-1012 results in increased phosphorylation of CHEK1 protein] | 24823293 |
| C000614725 | 3'-oxomethylisoeugenol | 3'-oxomethylisoeugenol results in increased phosphorylation of CHEK1 protein | 28818686 |
| C581009 | 4-(4-(3-methylmorpholin-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-2-yl)-1H-indole | 4-(4-(3-methylmorpholin-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-2-yl)-1H-indole inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] | 25448276 |
| C013813 | 4-anisidine | 4-anisidine results in decreased expression of CHEK1 mRNA | 12929121 |
| C006757 | 4-biphenylamine | 4-biphenylamine results in decreased expression of CHEK1 mRNA | 24857880 |
| C475622 | 4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine | "4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased phosphorylation of CHEK1 protein]" | 26208482 |
| C027576 | 4-hydroxy-2-nonenal | 4-hydroxy-2-nonenal results in decreased expression of CHEK1 mRNA | 19191707 |
| C054852 | 7-hydroxystaurosporine | 7-hydroxystaurosporine results in decreased activity of CHEK1 protein | 10998351|1606167 |
| C054852 | 7-hydroxystaurosporine | 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA] | 22403396 |
| C054852 | 7-hydroxystaurosporine | 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein] | 22403396 |
| C054852 | 7-hydroxystaurosporine | 7-hydroxystaurosporine inhibits the reaction [erythritol anhydride results in increased expression of CHEK1 protein modified form] | 25633853 |
| C054852 | 7-hydroxystaurosporine | [7-hydroxystaurosporine results in decreased activity of [CHEK1 protein co-treated with BSCL2 protein]] inhibits the reaction [Aphidicolin results in increased expression of CHEK2 mRNA] | 22003191 |
| C054852 | 7-hydroxystaurosporine | [7-hydroxystaurosporine results in decreased activity of [CHEK1 protein co-treated with BSCL2 protein]] inhibits the reaction [Cisplatin results in increased expression of CHEK2 mRNA] | 22003191 |
| C054852 | 7-hydroxystaurosporine | 7-hydroxystaurosporine results in decreased activity of CHEK1 protein | 19242509|2200319 |
| D000082 | Acetaminophen | Acetaminophen results in increased expression of CHEK1 protein | 20025956 |
| D000111 | Acetylcysteine | Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]] | 15489221 |
| D000111 | Acetylcysteine | Acetylcysteine inhibits the reaction [erythritol anhydride results in increased expression of CHEK1 protein modified form] | 25633853 |
| D020106 | Acrylamide | Acrylamide results in increased expression of CHEK1 protein | 20025956 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 affects the expression of CHEK1 protein | 20106945 |
| C038491 | allyl sulfide | allyl sulfide results in increased phosphorylation of CHEK1 protein | 24650757 |
| C038491 | allyl sulfide | CHEK1 protein promotes the reaction [allyl sulfide results in decreased expression of CCNB1 protein] | 24650757 |
| C038491 | allyl sulfide | CHEK1 protein promotes the reaction [allyl sulfide results in decreased expression of CDC25C protein] | 24650757 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of CHEK1 mRNA | 16483693 |
| D000643 | Ammonium Chloride | Ammonium Chloride results in decreased expression of CHEK1 protein | 16483693 |
| C059765 | amphotericin B, deoxycholate drug combination | "amphotericin B, deoxycholate drug combination results in increased expression of CHEK1 mRNA" | 22863853 |
| D000872 | Anthocyanins | Anthocyanins results in increased phosphorylation of CHEK1 protein | 27444805 |
| D016590 | Aphidicolin | [7-hydroxystaurosporine results in decreased activity of [CHEK1 protein co-treated with BSCL2 protein]] inhibits the reaction [Aphidicolin results in increased expression of CHEK2 mRNA] | 22003191 |
| D016590 | Aphidicolin | [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of CHEK1 protein] | 22003191 |
| C006632 | arsenic trioxide | arsenic trioxide results in increased phosphorylation of CHEK1 protein | 16891316 |
| C006632 | arsenic trioxide | arsenic trioxide results in increased phosphorylation of CHEK1 protein | 16891316 |
| C006632 | arsenic trioxide | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [arsenic trioxide results in increased phosphorylation of CHEK1 protein] | 23337567 |
| C006632 | arsenic trioxide | arsenic trioxide results in increased phosphorylation of CHEK1 protein | 23337567 |
| D017638 | Asbestos, Crocidolite | "Asbestos, Crocidolite results in increased expression of CHEK1 protein" | 21570478 |
| D001280 | Atrazine | Atrazine results in decreased expression of CHEK1 mRNA | 22378314 |
| C105832 | aurapten | aurapten affects the expression of CHEK1 mRNA | 23320178 |
| D001379 | Azathioprine | Azathioprine results in decreased expression of CHEK1 mRNA | 22623647 |
| C057620 | bafilomycin A | bafilomycin A inhibits the reaction [BO-1012 results in increased phosphorylation of CHEK1 protein] | 24823293 |
| C114062 | BBR 3464 | BBR 3464 results in decreased expression of CHEK1 protein | 12740909 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of CHEK1 mRNA | 21802500 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased phosphorylation of CHEK1 protein | 19464357|2022806 |
| D001564 | Benzo(a)pyrene | CLSPN mRNA affects the reaction [Benzo(a)pyrene results in increased phosphorylation of CHEK1 protein] | 19464357 |
| D001564 | Benzo(a)pyrene | cobaltous chloride promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of CHEK1 protein] | 20228066 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of CHEK1 protein modified form | 21604763 |
| D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CHEK1 mRNA" | 20018196|2038263 |
| D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CHEK1 mRNA" | 26238291 |
| D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | "7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of CHEK1 protein" | 22331492 |
| D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | "POLH protein affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of CHEK1 protein]" | 22331492 |
| D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | "POLK protein affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of CHEK1 protein]" | 22331492 |
| D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | "REV1 protein affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of CHEK1 protein]" | 22331492 |
| D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | "REV3L protein affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of CHEK1 protein]" | 22331492 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CHEK1 mRNA | 20061341 |
| D001599 | Berberine | Berberine results in increased expression of CHEK1 protein modified form | 23747414 |
| D004958 | Estradiol | Estradiol results in increased expression of CHEK1 mRNA | 16474171|1916744 |
| D004958 | Estradiol | ESR1 protein promotes the reaction [Estradiol results in increased expression of CHEK1 mRNA] | 25210133 |
| D004958 | Estradiol | Estradiol affects the expression of CHEK1 mRNA | 15598610 |
| D004958 | Estradiol | Estradiol results in increased expression of CHEK1 mRNA | 25210133 |
| C044887 | beta-methylcholine | beta-methylcholine affects the expression of CHEK1 mRNA | 21179406 |
| C006780 | bisphenol A | bisphenol A affects the expression of CHEK1 mRNA | 21786754 |
| C006780 | bisphenol A | bisphenol A results in increased expression of CHEK1 mRNA | 29027980 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of CHEK1 mRNA | 29275510 |
| C006780 | bisphenol A | bisphenol A results in increased expression of CHEK1 mRNA | 16474171 |
| C006780 | bisphenol A | bisphenol A affects the expression of CHEK1 mRNA | 21786754 |
| C006780 | bisphenol A | [bisphenol A co-treated with Testosterone] results in increased expression of CHEK1 mRNA | 26496021 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of CHEK1 mRNA | 25181051 |
| C000591165 | BO-1012 | 3-methyladenine inhibits the reaction [BO-1012 results in increased phosphorylation of CHEK1 protein] | 24823293 |
| C000591165 | BO-1012 | ATG7 mutant form inhibits the reaction [BO-1012 results in increased phosphorylation of CHEK1 protein] | 24823293 |
| C000591165 | BO-1012 | bafilomycin A inhibits the reaction [BO-1012 results in increased phosphorylation of CHEK1 protein] | 24823293 |
| C000591165 | BO-1012 | BO-1012 results in increased phosphorylation of and results in decreased expression of CHEK1 protein | 24823293 |
| C000591165 | BO-1012 | CHEK1 mutant form promotes the reaction [BO-1012 results in increased cleavage of PARP1 protein] | 24823293 |
| C546611 | brevetoxin 2 | brevetoxin 2 results in increased expression of CHEK1 mRNA | 20498034 |
| D002066 | Busulfan | [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK1 protein | 20933509 |
| D002084 | Butylated Hydroxytoluene | Butylated Hydroxytoluene results in increased expression of CHEK1 mRNA | 19000923 |
| D020122 | tert-Butylhydroperoxide | tert-Butylhydroperoxide results in decreased expression of CHEK1 mRNA | 12414654 |
| D002104 | Cadmium | Cadmium results in decreased expression of CHEK1 mRNA | 21120746 |
| D002110 | Caffeine | Caffeine inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein] | 19261750 |
| D002110 | Caffeine | Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]] | 18158334 |
| D002110 | Caffeine | Caffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]] | 15975956 |
| D002110 | Caffeine | Caffeine inhibits the reaction [resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]] | 15975956 |
| D002110 | Caffeine | Caffeine results in decreased phosphorylation of CHEK1 protein | 21561856 |
| D002110 | Caffeine | Caffeine results in increased phosphorylation of CHEK1 protein | 29074359 |
| D002110 | Caffeine | xanthatin inhibits the reaction [Caffeine results in increased phosphorylation of CHEK1 protein] | 29074359 |
| D002110 | Caffeine | Caffeine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA] | 22403396 |
| D002110 | Caffeine | Caffeine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein] | 22403396 |
| D002110 | Caffeine | Caffeine results in decreased expression of CHEK1 protein modified form | 21505179 |
| D002166 | Camptothecin | 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form] | 25269479 |
| D002166 | Camptothecin | Camptothecin results in increased expression of CHEK1 protein modified form | 25269479 |
| D002166 | Camptothecin | Camptothecin results in increased phosphorylation of CHEK1 protein | 21646468 |
| D002166 | Camptothecin | CHEK1 mRNA results in decreased susceptibility to Camptothecin | 25269479 |
| D002166 | Camptothecin | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein] | 22403396 |
| D002166 | Camptothecin | 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA] | 22403396 |
| D002166 | Camptothecin | 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein] | 22403396 |
| D002166 | Camptothecin | Caffeine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA] | 22403396 |
| D002166 | Camptothecin | Caffeine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein] | 22403396 |
| D002166 | Camptothecin | Camptothecin results in increased expression of CHEK1 mRNA | 22403396 |
| D002166 | Camptothecin | Camptothecin results in increased phosphorylation of CHEK1 protein | 22403396 |
| D002220 | Carbamazepine | Carbamazepine affects the expression of CHEK1 mRNA | 24752500 |
| C089486 | carbobenzoxy-leucyl-leucyl-norvalinal | carbobenzoxy-leucyl-leucyl-norvalinal inhibits the reaction [10-decarbamoylmitomycin C results in decreased expression of CHEK1 protein] | 20536192 |
| D002330 | Carmustine | ATR protein affects the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein] | 19261750 |
| D002330 | Carmustine | Caffeine inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein] | 19261750 |
| D002330 | Carmustine | Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein | 19261750 |
| D002330 | Carmustine | O(6)-benzylguanine promotes the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein] | 19261750 |
| D002330 | Carmustine | wortmannin inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein] | 19261750 |
| C034221 | catechol | catechol results in increased expression of CHEK1 protein | 20025956 |
| D002509 | Cephaloridine | Cephaloridine results in increased expression of CHEK1 mRNA | 18500788 |
| C518919 | CHIR-124 | CHIR-124 results in decreased activity of CHEK1 protein | 23897988 |
| D004390 | Chlorpyrifos | Chlorpyrifos results in decreased expression of CHEK1 mRNA | 20350560 |
| D019826 | Cholic Acid | Cholic Acid results in increased expression of CHEK1 protein | 20025956 |
| D002794 | Choline | Choline affects the expression of CHEK1 mRNA | 17616785 |
| D002794 | Choline | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHEK1 mRNA | 20938992 |
| D002939 | Ciprofloxacin | Ciprofloxacin results in increased expression of CHEK1 protein | 18512786 |
| C068329 | clofarabine | [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK1 protein | 20933509 |
| D002994 | Clofibrate | Clofibrate results in increased expression of CHEK1 protein | 20025956 |
| C034456 | CMF regimen | CHEK1 protein modified form affects the susceptibility to CMF regimen | 25688741 |
| C018021 | cobaltous chloride | cobaltous chloride promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of CHEK1 protein] | 20228066 |
| C018021 | cobaltous chloride | cobaltous chloride results in decreased expression of CHEK1 mRNA | 19320972|1937684 |
| C018021 | cobaltous chloride | cobaltous chloride results in increased phosphorylation of CHEK1 protein | 20228066 |
| D003300 | Copper | [NSC 689534 binds to Copper] which results in decreased expression of CHEK1 mRNA | 20971185 |
| D003300 | Copper | Copper results in increased expression of CHEK1 mRNA | 22465980 |
| C464760 | copper-1,10-phenanthroline | "copper-1,10-phenanthroline results in increased phosphorylation of CHEK1 protein" | 24638265 |
| D019327 | Copper Sulfate | Copper Sulfate results in decreased expression of CHEK1 mRNA | 19549813 |
| D003375 | Coumestrol | "[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CHEK1 mRNA" | 19167446 |
| D003375 | Coumestrol | [Coumestrol co-treated with resveratrol] results in increased expression of CHEK1 mRNA | 19167446 |
| D003375 | Coumestrol | Coumestrol results in increased expression of CHEK1 mRNA | 19167446 |
| C408982 | CPG-oligonucleotide | CPG-oligonucleotide results in decreased expression of CHEK1 mRNA | 21878529 |
| C408982 | CPG-oligonucleotide | CPG-oligonucleotide results in decreased expression of CHEK1 mRNA | 21878529 |
| D003474 | Curcumin | CHEK1 protein results in decreased susceptibility to Curcumin | 18602917 |
| D003474 | Curcumin | Curcumin results in increased activity of CHEK1 protein | 18602917 |
| D003474 | Curcumin | Curcumin results in increased phosphorylation of CHEK1 protein | 19401701 |
| D016572 | Cyclosporine | Cyclosporine results in decreased expression of CHEK1 mRNA | 20106945|2163298 |
| D016572 | Cyclosporine | Cyclosporine results in decreased expression of CHEK1 mRNA | 25270620 |
| C089595 | cylindrospermopsin | cylindrospermopsin results in increased expression of CHEK1 mRNA | 23726867 |
| C114768 | decamethylcyclopentasiloxane | decamethylcyclopentasiloxane results in decreased expression of CHEK1 mRNA | 27601420 |
| C014347 | decitabine | decitabine affects the localization of CHEK1 protein modified form | 17991895 |
| C100261 | diacetyldiphenylurea bisguanylhydrazone | diacetyldiphenylurea bisguanylhydrazone results in decreased activity of CHEK1 protein | 23897988 |
| D003993 | Dibutyl Phthalate | Dibutyl Phthalate results in decreased expression of CHEK1 mRNA | 21266533 |
| D002945 | Cisplatin | BRCA1 mutant form promotes the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased activity of and results in increased phosphorylation of CHEK1 protein]]] | 21875941 |
| D002945 | Cisplatin | CHEK1 mutant form promotes the reaction [TP53 mutant form results in increased susceptibility to Cisplatin] | 21875941 |
| D002945 | Cisplatin | Cisplatin results in decreased expression of CHEK1 protein | 12740909 |
| D002945 | Cisplatin | Cisplatin results in increased activity of CHEK1 protein | 21324906|2159254 |
| D002945 | Cisplatin | Cisplatin results in increased phosphorylation of and results in increased activity of CHEK1 protein | 21107699|2187594 |
| D002945 | Cisplatin | Cisplatin results in increased phosphorylation of CHEK1 protein | 20623183|2128535 |
| D002945 | Cisplatin | ERCC6 protein inhibits the reaction [Cisplatin results in increased activity of CHEK1 protein] | 21324906 |
| D002945 | Cisplatin | ESR2 protein inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein] | 20623183 |
| D002945 | Cisplatin | Lovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein] | 21356574 |
| D002945 | Cisplatin | RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of CHEK1 protein]] | 21875941 |
| D002945 | Cisplatin | TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of CHEK1 protein] | 21875941 |
| D002945 | Cisplatin | [7-hydroxystaurosporine results in decreased activity of [CHEK1 protein co-treated with BSCL2 protein]] inhibits the reaction [Cisplatin results in increased expression of CHEK2 mRNA] | 22003191 |
| D002945 | Cisplatin | Cisplatin results in increased phosphorylation of CHEK1 protein | 21285353|2200601 |
| D002945 | Cisplatin | PRKDC protein mutant form promotes the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein] | 21324906 |
| D002945 | Cisplatin | [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein] | 22003191 |
| D002945 | Cisplatin | Cisplatin results in increased expression of CHEK1 protein modified form | 26739623 |
| D002945 | Cisplatin | Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK1 protein modified form] | 26739623 |
| D004008 | Diclofenac | Diclofenac affects the expression of CHEK1 mRNA | 24752500 |
| C000944 | dicrotophos | dicrotophos results in decreased expression of CHEK1 mRNA | 28302478 |
| D004052 | Diethylnitrosamine | ATM protein inhibits the reaction [Diethylnitrosamine results in increased expression of CHEK1 mRNA] | 19919837 |
| D004052 | Diethylnitrosamine | ATM protein inhibits the reaction [Diethylnitrosamine results in increased expression of CHEK1 protein] | 19919837 |
| D004052 | Diethylnitrosamine | Diethylnitrosamine results in increased expression of CHEK1 mRNA | 17854601|1991983 |
| D004052 | Diethylnitrosamine | Diethylnitrosamine results in increased expression of CHEK1 protein | 19919837 |
| D004052 | Diethylnitrosamine | RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CHEK1 mRNA] | 17854601 |
| D004052 | Diethylnitrosamine | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CHEK1 mRNA | 22129741 |
| C011612 | diethyl sulfate | diethyl sulfate results in decreased expression of CHEK1 protein modified form | 23830811 |
| C011612 | diethyl sulfate | diethyl sulfate results in increased expression of CHEK1 protein modified form | 23830811 |
| D004074 | Digitoxin | Digitoxin analog results in decreased expression of CHEK1 protein | 22037315 |
| D004074 | Digitoxin | Digitoxin results in decreased expression of CHEK1 protein | 22037315 |
| D000875 | Anthralin | Anthralin results in increased expression of CHEK1 protein | 20025956 |
| D015127 | 9,10-Dimethyl-1,2-benzanthracene | "9,10-Dimethyl-1,2-benzanthracene results in increased expression of CHEK1 protein" | 20025956 |
| D004147 | Dioxins | Dioxins affects the expression of CHEK1 mRNA | 20463971 |
| D004317 | Doxorubicin | 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Doxorubicin results in increased phosphorylation of CHEK1 protein] | 17085670 |
| D004317 | Doxorubicin | Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]] | 15489221 |
| D004317 | Doxorubicin | CHEK1 protein affects the susceptibility to Doxorubicin | 16217747|1869803 |
| D004317 | Doxorubicin | Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein] | 15489221 |
| D004317 | Doxorubicin | Doxorubicin promotes the reaction [DNMT1 protein binds to CHEK1 protein] | 17991895 |
| D004317 | Doxorubicin | Doxorubicin results in decreased expression of CHEK1 mRNA | 16036217 |
| D004317 | Doxorubicin | Doxorubicin results in decreased expression of CHEK1 protein | 15870702 |
| D004317 | Doxorubicin | Doxorubicin results in increased phosphorylation of and results in increased activity of CHEK1 protein | 17320279 |
| D004317 | Doxorubicin | Doxorubicin results in increased phosphorylation of CHEK1 protein | 17085670|1708886 |
| D004317 | Doxorubicin | Lovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of CHEK1 protein] | 17088865|2135657 |
| D004317 | Doxorubicin | [SB 218078 results in decreased activity of CHEK1 protein] which results in increased susceptibility to Doxorubicin | 17085670 |
| D004317 | Doxorubicin | TP53 protein affects the reaction [CHEK1 protein affects the susceptibility to Doxorubicin] | 18698031 |
| D060754 | Equol | Equol results in decreased expression of CHEK1 mRNA | 16865672 |
| C007366 | erythritol anhydride | 7-hydroxystaurosporine inhibits the reaction [erythritol anhydride results in increased expression of CHEK1 protein modified form] | 25633853 |
| C007366 | erythritol anhydride | Acetylcysteine inhibits the reaction [erythritol anhydride results in increased expression of CHEK1 protein modified form] | 25633853 |
| C007366 | erythritol anhydride | CHEK1 protein promotes the reaction [erythritol anhydride results in increased expression of CDC25C protein modified form] | 25633853 |
| C007366 | erythritol anhydride | CHEK1 protein promotes the reaction [erythritol anhydride results in increased expression of CDK1 protein modified form] | 25633853 |
| C007366 | erythritol anhydride | erythritol anhydride results in increased expression of CHEK1 protein modified form | 25633853 |
| C007366 | erythritol anhydride | erythritol anhydride results in increased phosphorylation of CHEK1 protein | 25633853 |
| C007633 | estragole | estragole results in increased expression of CHEK1 protein | 29054680 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol affects the expression of CHEK1 mRNA | 17555576 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased expression of CHEK1 mRNA | 17942748 |
| D004997 | Ethinyl Estradiol | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CHEK1 mRNA | 17942748 |
| C002994 | ethylene dimethanesulfonate | ethylene dimethanesulfonate results in increased expression of CHEK1 mRNA | 22711419 |
| D005047 | Etoposide | CHEK1 protein affects the susceptibility to Etoposide | 18698031 |
| D005047 | Etoposide | TP53 protein affects the reaction [CHEK1 protein affects the susceptibility to Etoposide] | 18698031 |
| D011345 | Fenofibrate | Fenofibrate results in increased expression of CHEK1 mRNA | 17264098 |
| C024555 | ferric chloride | ferric chloride results in increased expression of CHEK1 protein | 20025956 |
| C029451 | ferrous chloride | ferrous chloride results in increased expression of CHEK1 protein | 20025956 |
| C017875 | fisetin | fisetin results in increased expression of CHEK1 protein | 28181380 |
| D005419 | Flavonoids | Flavonoids results in decreased expression of CHEK1 mRNA | 18035473 |
| D005467 | Floxuridine | Floxuridine results in increased phosphorylation of and results in increased activity of CHEK1 protein | 21613406|2219493 |
| C024352 | fludarabine | [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK1 protein | 20933509 |
| C024352 | fludarabine | [LAQ824 co-treated with fludarabine] results in decreased expression of CHEK1 mRNA | 18852132 |
| C012976 | flumequine | "[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CHEK1 mRNA" | 23681119 |
| D005472 | Fluorouracil | CHEK1 protein affects the susceptibility to Fluorouracil | 16619043 |
| D005472 | Fluorouracil | Fluorouracil results in increased phosphorylation of and results in increased activity of CHEK1 protein | 16619043 |
| D005472 | Fluorouracil | CHEK1 protein affects the susceptibility to Fluorouracil | 18698031 |
| D005472 | Fluorouracil | [CHEK1 protein co-treated with TP53 protein] affects the susceptibility to Fluorouracil | 18698031 |
| D005472 | Fluorouracil | Fluorouracil results in increased expression of CHEK1 protein | 15016801 |
| D005472 | Fluorouracil | Fluorouracil results in increased phosphorylation of and results in increased activity of CHEK1 protein | 21613406|2219493 |
| D005472 | Fluorouracil | TP53 protein affects the reaction [CHEK1 protein affects the susceptibility to Fluorouracil] | 18698031 |
| D005472 | Fluorouracil | TP53 protein affects the reaction [Fluorouracil results in decreased expression of CHEK1 mRNA] | 15016801 |
| D005472 | Fluorouracil | TP53 protein inhibits the reaction [Fluorouracil results in increased expression of CHEK1 protein] | 15016801 |
| D005472 | Fluorouracil | Fluorouracil results in decreased expression of CHEK1 mRNA | 19272435 |
| D005492 | Folic Acid | Folic Acid affects the expression of CHEK1 mRNA | 16361273 |
| D005492 | Folic Acid | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHEK1 mRNA | 20938992 |
| C039281 | furan | furan results in increased expression of CHEK1 mRNA | 20194422 |
| C039281 | furan | furan results in increased expression of CHEK1 mRNA | 20562052|2207923 |
| D005665 | Furosemide | Furosemide affects the expression of CHEK1 mRNA | 17497460 |
| D019833 | Genistein | Genistein results in increased expression of CHEK1 mRNA | 16474171 |
| C071834 | glycidamide | glycidamide affects the expression of CHEK1 protein | 21978862 |
| C081021 | Go 6976 | Go 6976 results in decreased activity of CHEK1 protein | 10998351|2061953 |
| C081021 | Go 6976 | Go 6976 results in increased phosphorylation of CHEK1 protein | 29074359 |
| C081021 | Go 6976 | xanthatin inhibits the reaction [Go 6976 results in increased phosphorylation of CHEK1 protein] | 29074359 |
| D006046 | Gold | [Polyethyleneimine binds to Gold] which results in decreased expression of CHEK1 mRNA | 28433809 |
| C479979 | GW0742 | [GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of CHEK1 mRNA] | 22473992 |
| C479979 | GW0742 | [GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of CHEK1 protein] | 22473992 |
| C479979 | GW0742 | [GW0742 binds to and results in increased activity of PPARD protein] which results in decreased expression of CHEK1 protein | 22473992 |
| C024035 | hexamethylcyclotrisiloxane | hexamethylcyclotrisiloxane results in decreased expression of CHEK1 mRNA | 27601420 |
| D006835 | Hydrazones | Hydrazones results in increased expression of CHEK1 protein | 28716444 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in decreased expression of CHEK1 mRNA | 12414654 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in increased expression of CHEK1 mRNA | 25972194 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in increased expression of CHEK1 protein | 25972194 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in increased phosphorylation of CHEK1 protein | 26208482|2907435 |
| D006861 | Hydrogen Peroxide | MIRLET7G mRNA inhibits the reaction [Hydrogen Peroxide results in increased expression of CHEK1 protein] | 25972194 |
| D006918 | Hydroxyurea | Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]] | 18158334 |
| D006918 | Hydroxyurea | Hydroxyurea results in decreased expression of CHEK1 mRNA | 12929121 |
| C107079 | hymenialdisine | hymenialdisine results in decreased activity of CHEK1 protein | 21615147 |
| C016517 | indole-3-carbinol | indole-3-carbinol affects the expression of CHEK1 mRNA | 21396975 |
| C016517 | indole-3-carbinol | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CHEK1 mRNA | 22129741 |
| D015759 | Ionomycin | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CHEK1 mRNA | 25613284 |
| C051890 | irinotecan | irinotecan results in increased phosphorylation of and results in increased activity of CHEK1 protein | 22510560 |
| C051890 | irinotecan | irinotecan results in increased phosphorylation of CHEK1 protein | 22111927|2289888 |
| C051890 | irinotecan | SAR 020106 inhibits the reaction [irinotecan results in increased phosphorylation of CHEK1 protein] | 22111927 |
| D007530 | Isoflurane | Isoflurane results in decreased expression of CHEK1 mRNA | 16978161 |
| C561695 | (+)-JQ1 compound | [(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of CHEK1 mRNA | 27169980 |
| C561695 | (+)-JQ1 compound | (+)-JQ1 compound results in decreased expression of CHEK1 mRNA | 24796395|2596192 |
| C006552 | kaempferol | kaempferol results in increased phosphorylation of CHEK1 protein | 24595819 |
| C477361 | LAQ824 | [LAQ824 co-treated with fludarabine] results in decreased expression of CHEK1 mRNA | 18852132 |
| D007854 | Lead | Lead affects the expression of CHEK1 mRNA | 28903495 |
| C008261 | lead acetate | lead acetate results in increased expression of CHEK1 mRNA | 22609695 |
| C045463 | leflunomide | leflunomide results in decreased expression of CHEK1 mRNA | 24136188 |
| C038753 | leptomycin B | leptomycin B results in decreased expression of CHEK1 mRNA | 20803015 |
| C506643 | liposomal doxorubicin | liposomal doxorubicin results in increased phosphorylation of CHEK1 protein | 27923599 |
| D008148 | Lovastatin | Lovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein] | 21356574 |
| D008148 | Lovastatin | Lovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of CHEK1 protein] | 17088865|2135657 |
| D008148 | Lovastatin | Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK1 protein modified form] | 26739623 |
| C582547 | LY2603618 | LY2603618 results in decreased activity of CHEK1 protein | 23897988 |
| D058185 | Magnetite Nanoparticles | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CHEK1 mRNA | 21641980 |
| C005095 | malachite green | malachite green results in increased phosphorylation of CHEK1 protein | 16085357 |
| D008558 | Melphalan | Melphalan results in increased phosphorylation of CHEK1 protein | 26208482 |
| D008701 | Methapyrilene | Methapyrilene results in increased expression of CHEK1 mRNA | 26558467 |
| D008715 | Methionine | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHEK1 mRNA | 20938992 |
| D008727 | Methotrexate | CHEK1 protein results in decreased susceptibility to Methotrexate | 22484375 |
| D008727 | Methotrexate | Methotrexate promotes the reaction [E2F1 protein binds to CHEK1 promoter] | 22484375 |
| D008727 | Methotrexate | Methotrexate results in increased expression of and results in increased phosphorylation of and results in increased activity of CHEK1 protein | 22484375 |
| D008727 | Methotrexate | Methotrexate results in increased expression of CHEK1 mRNA | 22484375 |
| D008727 | Methotrexate | Methotrexate promotes the reaction [E2F1 protein binds to CHEK1 promoter] | 22484375 |
| D008727 | Methotrexate | Methotrexate results in increased expression of CHEK1 protein modified form | 22484375 |
| C005223 | methyleugenol | methyleugenol affects the expression of CHEK1 mRNA | 26011634 |
| C000614724 | methyleugenol-2',3'-epoxide | "methyleugenol-2',3'-epoxide results in increased phosphorylation of CHEK1 protein" | 28818686 |
| C032429 | methyl farnesoate | methyl farnesoate results in increased expression of CHEK1 mRNA | 27553699 |
| C008461 | methyl isocyanate | methyl isocyanate results in increased expression of CHEK1 mRNA | 22223508 |
| C004925 | methylmercuric chloride | methylmercuric chloride results in decreased expression of CHEK1 mRNA | 20061341 |
| D018817 | N-Methyl-3,4-methylenedioxyamphetamine | "N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CHEK1 mRNA" | 20188158 |
| D015741 | Metribolone | Metribolone results in increased expression of CHEK1 mRNA | 19318562 |
| D015741 | Metribolone | Metribolone results in increased phosphorylation of CHEK1 protein | 23272087 |
| C011309 | mezerein | mezerein results in increased expression of CHEK1 mRNA | 19000923 |
| D015735 | Mifepristone | Mifepristone inhibits the reaction [Progesterone results in increased phosphorylation of CHEK1 protein] | 22403396 |
| D016685 | Mitomycin | Mitomycin results in increased phosphorylation of CHEK1 protein | 26208482 |
| C559815 | MK-8776 | MK-8776 results in decreased activity of CHEK1 protein | 23897988 |
| C559815 | MK-8776 | MK-8776 results in decreased activity of CHEK1 protein | 22510560 |
| C406082 | monomethylarsonous acid | monomethylarsonous acid results in decreased expression of CHEK1 protein | 24625837 |
| D009151 | Mustard Gas | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] | 22119920 |
| D009151 | Mustard Gas | 4-(4-(3-methylmorpholin-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-2-yl)-1H-indole inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] | 25448276 |
| D009151 | Mustard Gas | Mustard Gas results in increased phosphorylation of CHEK1 protein | 22119920|2544827 |
| D009151 | Mustard Gas | PF 00477736 inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] | 25448276 |
| D009151 | Mustard Gas | wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] | 22119920 |
| C000621033 | napabucasin | napabucasin results in decreased expression of CHEK1 mRNA | 25605917 |
| D009532 | Nickel | Nickel results in decreased expression of CHEK1 mRNA | 24768652 |
| D009532 | Nickel | Nickel results in increased expression of CHEK1 mRNA | 25583101 |
| D015376 | Nimustine | FOSL1 protein affects the reaction [Nimustine results in increased phosphorylation of CHEK1 protein] | 22609303 |
| D015376 | Nimustine | Nimustine results in increased phosphorylation of CHEK1 protein | 22609303 |
| D015739 | Nocodazole | Nocodazole results in decreased expression of CHEK1 protein | 26914363 |
| C069741 | norcantharidin | norcantharidin results in increased phosphorylation of CHEK1 protein | 21266192 |
| C558013 | NSC 689534 | [NSC 689534 binds to Copper] which results in decreased expression of CHEK1 mRNA | 20971185 |
| C553898 | NSC 724998 | 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [NSC 724998 results in increased expression of CHEK1 protein modified form] | 25269479 |
| C553898 | NSC 724998 | NSC 724998 results in increased expression of CHEK1 protein modified form | 25269479 |
| C064976 | O(6)-benzylguanine | O(6)-benzylguanine promotes the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein] | 19261750 |
| C025589 | ochratoxin A | ochratoxin A results in decreased acetylation of CHEK1 promoter | 29098329 |
| C025589 | ochratoxin A | ochratoxin A results in increased expression of CHEK1 mRNA | 19237604|2335814 |
| C024064 | octamethylcyclotetrasiloxane | octamethylcyclotetrasiloxane results in decreased expression of CHEK1 mRNA | 27601420 |
| C507134 | ON 01910 | ON 01910 results in decreased expression of and results in decreased phosphorylation of CHEK1 protein | 21646468 |
| C030110 | oxaliplatin | [oxaliplatin co-treated with Topotecan] results in decreased expression of CHEK1 mRNA | 25729387 |
| C030110 | oxaliplatin | oxaliplatin results in decreased expression of CHEK1 mRNA | 25729387 |
| C011030 | oxfendazole | oxfendazole affects the expression of CHEK1 mRNA | 26558467 |
| D010126 | Ozone | Ozone results in increased expression of CHEK1 mRNA | 19555225 |
| D017239 | Paclitaxel | Paclitaxel results in decreased expression of CHEK1 mRNA | 12929121 |
| D052638 | Particulate Matter | 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of CHEK1 mRNA] | 28655636 |
| D052638 | Particulate Matter | Particulate Matter results in decreased expression of CHEK1 mRNA | 28655636 |
| C410127 | PCB 180 | PCB 180 results in increased phosphorylation of CHEK1 protein | 26148434 |
| C544549 | PD 407824 | PD 407824 results in decreased activity of CHEK1 protein | 23897988 |
| D010575 | Pesticides | Pesticides results in decreased methylation of CHEK1 gene | 28396702 |
| C532366 | PF 00477736 | PF 00477736 inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] | 25448276 |
| C532366 | PF 00477736 | PF 00477736 results in decreased activity of CHEK1 protein | 21707865 |
| D010634 | Phenobarbital | Phenobarbital affects the expression of CHEK1 mRNA | 23091169 |
| C006253 | pirinixic acid | [pirinixic acid co-treated with PPARA] results in increased expression of CHEK1 mRNA | 20813756 |
| C006253 | pirinixic acid | pirinixic acid results in increased expression of CHEK1 mRNA | 20813756 |
| D010936 | Plant Extracts | Plant Extracts results in increased phosphorylation of CHEK1 protein | 22143989 |
| D010936 | Plant Extracts | Plant Extracts results in increased phosphorylation of CHEK1 protein | 24595819 |
| D010984 | Platinum | Platinum analog results in increased phosphorylation of and results in increased activity of CHEK1 protein | 21107699 |
| D011078 | Polychlorinated Biphenyls | Polychlorinated Biphenyls analog results in increased expression of CHEK1 mRNA | 16474171 |
| D011094 | Polyethyleneimine | [Polyethyleneimine binds to Gold] which results in decreased expression of CHEK1 mRNA | 28433809 |
| D011285 | Pregnenolone Carbonitrile | "[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of CHEK1 mRNA" | 23626729 |
| D011374 | Progesterone | Progesterone results in decreased expression of CHEK1 mRNA | 23012394 |
| D011374 | Progesterone | Mifepristone inhibits the reaction [Progesterone results in increased phosphorylation of CHEK1 protein] | 22403396 |
| D011374 | Progesterone | Progesterone results in increased phosphorylation of CHEK1 protein | 22403396 |
| D011374 | Progesterone | Progesterone results in decreased expression of CHEK1 mRNA | 20726854 |
| D011398 | Promethazine | Promethazine results in decreased expression of CHEK1 mRNA | 26011634 |
| D011398 | Promethazine | Promethazine results in increased expression of CHEK1 mRNA | 26558467 |
| C045950 | propiconazole | propiconazole results in increased expression of CHEK1 mRNA | 21278054 |
| D011441 | Propylthiouracil | Propylthiouracil results in increased expression of CHEK1 mRNA | 24780913 |
| C043680 | ptaquiloside | ptaquiloside results in increased phosphorylation of CHEK1 protein | 22143989 |
| D011794 | Quercetin | Quercetin results in decreased expression of CHEK1 mRNA | 23727915 |
| D011794 | Quercetin | Quercetin results in decreased expression of CHEK1 mRNA | 25862958 |
| D011794 | Quercetin | Quercetin results in increased phosphorylation of CHEK1 protein | 24595819 |
| C059514 | resveratrol | Caffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]] | 15975956 |
| C059514 | resveratrol | Caffeine inhibits the reaction [resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]] | 15975956 |
| C059514 | resveratrol | [Coumestrol co-treated with resveratrol] results in increased expression of CHEK1 mRNA | 19167446 |
| C059514 | resveratrol | resveratrol affects the expression of CHEK1 protein | 18089832 |
| C059514 | resveratrol | resveratrol results in decreased expression of CHEK1 mRNA | 18089832 |
| C059514 | resveratrol | [resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein] | 15975956 |
| C059514 | resveratrol | resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein] | 15975956 |
| C059514 | resveratrol | [resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]] which results in increased phosphorylation of CDC25C protein | 15975956 |
| C059514 | resveratrol | resveratrol results in increased expression of CHEK1 mRNA | 19167446 |
| C547185 | riccardin D | riccardin D results in decreased expression of CHEK1 mRNA | 24069304 |
| C547185 | riccardin D | riccardin D results in increased phosphorylation of CHEK1 protein | 24069304 |
| C089032 | rimonabant | rimonabant results in decreased phosphorylation of CHEK1 protein | 19479993 |
| D012402 | Rotenone | Rotenone results in increased expression of CHEK1 mRNA | 18191903 |
| D012439 | Saccharin | Saccharin results in increased expression of CHEK1 mRNA | 19000923 |
| C547874 | SAR 020106 | SAR 020106 inhibits the reaction [irinotecan results in increased phosphorylation of CHEK1 protein] | 22111927 |
| C547874 | SAR 020106 | SAR 020106 results in decreased activity of CHEK1 protein | 22111927 |
| C404329 | SB 218078 | SB 218078 results in decreased activity of CHEK1 protein | 23897988 |
| C404329 | SB 218078 | [SB 218078 results in decreased activity of CHEK1 protein] which results in increased susceptibility to Doxorubicin | 17085670 |
| C404329 | SB 218078 | SB 218078 results in decreased expression of and results in decreased activity of CHEK1 protein | 17085670 |
| C015499 | schizandrin B | [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of CHEK1 protein] | 22003191 |
| C015499 | schizandrin B | [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein] | 22003191 |
| D017655 | Silicon Compounds | Silicon Compounds results in increased expression of CHEK1 protein | 23620807 |
| D012835 | Silver Nitrate | Silver Nitrate analog results in increased expression of CHEK1 mRNA | 22831968 |
| D012977 | Sodium Nitrite | Sodium Nitrite results in increased expression of CHEK1 protein | 20025956 |
| D012989 | Soil Pollutants | CHEK1 mutant form promotes the reaction [Soil Pollutants results in increased phosphorylation of H2AFX protein] | 22409540 |
| D012989 | Soil Pollutants | CHEK1 results in decreased susceptibility to Soil Pollutants | 22409540 |
| D012989 | Soil Pollutants | Soil Pollutants analog results in increased phosphorylation of CHEK1 protein | 22409540 |
| D012989 | Soil Pollutants | Soil Pollutants results in increased phosphorylation of CHEK1 protein | 22409540 |
| C049985 | staurosporine aglycone | staurosporine aglycone results in decreased activity of CHEK1 protein | 10998351 |
| D013241 | Sterigmatocystin | ATR protein promotes the reaction [Sterigmatocystin results in increased phosphorylation of CHEK1 protein] | 26914363 |
| D013241 | Sterigmatocystin | Sterigmatocystin results in increased expression of and results in increased phosphorylation of CHEK1 protein | 26914363 |
| D013241 | Sterigmatocystin | Sterigmatocystin results in increased expression of CHEK1 protein modified form | 26914363 |
| C013690 | styrene oxide | styrene oxide results in increased expression of CHEK1 protein | 20025956 |
| D004113 | Succimer | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CHEK1 mRNA | 21641980 |
| D014284 | Triiodothyronine | Triiodothyronine analog results in increased phosphorylation of CHEK1 protein | 22383522 |
| D013629 | Tamoxifen | Tamoxifen affects the expression of CHEK1 mRNA | 17555576 |
| C047246 | temozolomide | temozolomide results in increased phosphorylation of CHEK1 protein | 15930307 |
| D013739 | Testosterone | [bisphenol A co-treated with Testosterone] results in increased expression of CHEK1 mRNA | 26496021 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of CHEK1 mRNA | 21802500 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of CHEK1 mRNA | 21570461 |
| D013749 | Tetrachlorodibenzodioxin | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CHEK1 mRNA | 17942748 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of CHEK1 mRNA | 15667827|1946511 |
| D013755 | Tetradecanoylphorbol Acetate | Tetradecanoylphorbol Acetate results in increased expression of CHEK1 mRNA | 19000923 |
| D013755 | Tetradecanoylphorbol Acetate | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CHEK1 mRNA | 25613284 |
| D019284 | Thapsigargin | Thapsigargin results in decreased expression of CHEK1 mRNA | 22378314 |
| D013853 | Thioacetamide | Thioacetamide results in increased expression of CHEK1 mRNA | 22659510|2341159 |
| D013853 | Thioacetamide | Thioacetamide results in increased phosphorylation of CHEK1 protein | 22659510 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in increased expression of CHEK1 mRNA | 27865774 |
| D019772 | Topotecan | [oxaliplatin co-treated with Topotecan] results in decreased expression of CHEK1 mRNA | 25729387 |
| D019772 | Topotecan | Topotecan results in increased activity of CHEK1 protein | 22101337 |
| D014212 | Tretinoin | Tretinoin affects the expression of CHEK1 mRNA | 23724009 |
| D014212 | Tretinoin | Tretinoin results in decreased expression of CHEK1 mRNA | 21934132 |
| D014212 | Tretinoin | Tretinoin results in increased expression of CHEK1 protein | 20025956 |
| C012589 | trichostatin A | trichostatin A results in decreased expression of CHEK1 mRNA | 23770000 |
| C015559 | trimellitic anhydride | trimellitic anhydride results in increased expression of CHEK1 mRNA | 19042947 |
| C057693 | troglitazone | troglitazone results in decreased expression of CHEK1 mRNA | 19140230 |
| C073339 | usnic acid | usnic acid results in increased expression of CHEK1 protein modified form | 27369375 |
| D014635 | Valproic Acid | Valproic Acid affects the expression of CHEK1 mRNA | 25979313 |
| D014635 | Valproic Acid | Valproic Acid results in decreased expression of CHEK1 mRNA | 20585447|2317975 |
| D014638 | Vanadates | Vanadates results in increased expression of CHEK1 mRNA | 19000923 |
| D001335 | Vehicle Emissions | 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of CHEK1 mRNA] | 28655636 |
| D001335 | Vehicle Emissions | Vehicle Emissions analog results in increased phosphorylation of CHEK1 protein | 25500124 |
| D001335 | Vehicle Emissions | Vehicle Emissions results in decreased expression of CHEK1 mRNA | 28655636 |
| D001335 | Vehicle Emissions | Vehicle Emissions results in increased methylation of CHEK1 gene | 25560391 |
| C551177 | vemurafenib | [(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of CHEK1 mRNA | 27169980 |
| C029297 | vinylidene chloride | vinylidene chloride results in increased expression of CHEK1 mRNA | 26682919 |
| D014800 | Vitallium | Vitallium analog results in decreased expression of CHEK1 mRNA | 23825117 |
| D024483 | Vitamin K 3 | Vitamin K 3 results in decreased expression of CHEK1 mRNA | 12414654 |
| C009687 | wortmannin | wortmannin inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein] | 19261750 |
| C009687 | wortmannin | wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] | 22119920 |
| C009687 | wortmannin | wortmannin results in decreased expression of CHEK1 protein | 22409540 |
| C022186 | xanthatin | TP53 protein promotes the reaction [xanthatin results in decreased phosphorylation of CHEK1 protein] | 29074359 |
| C022186 | xanthatin | xanthatin affects the phosphorylation of CHEK1 protein | 29074359 |
| C022186 | xanthatin | xanthatin inhibits the reaction [Caffeine results in increased phosphorylation of CHEK1 protein] | 29074359 |
| C022186 | xanthatin | xanthatin inhibits the reaction [Go 6976 results in increased phosphorylation of CHEK1 protein] | 29074359 |
| D015215 | Zidovudine | Zidovudine results in decreased expression of CHEK1 protein | 19541796 |
| D015215 | Zidovudine | Zidovudine results in increased phosphorylation of CHEK1 protein | 19541796 |
| C016837 | zinc chloride | zinc chloride results in increased expression of CHEK1 mRNA | 19000923 |