Gene: HIBADH

11112
NS5ATP1
3-hydroxyisobutyrate dehydrogenase
protein-coding
7p15.2
Ensembl:ENSG00000106049 MIM:608475 Vega:OTTHUMG00000097035 UniprotKB:P31937
NC_000007.14
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.570e-1 (AD)  1.645e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNX50.91
SRI0.892
ADH50.884
COX200.88
SRP90.879
DARS0.876
PRDX10.874
ETFA0.872
SCP20.87
HMGN30.87

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.751
OR4F29-0.729
HDGFL1-0.202
COL22A1-0.201
OR7C2-0.191
DEFB126-0.175
LOXHD1-0.173
RHO-0.173
L1TD1-0.172
DCSTAMP-0.171

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HIBADH mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of HIBADH mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIBADH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIBADH mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of HIBADH mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of HIBADH mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of HIBADH mRNA17522070
D000393Air Pollutants[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of HIBADH gene27448387
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HIBADH mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HIBADH mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of HIBADH mRNA22521957
C547126AZM551248AZM551248 results in decreased expression of HIBADH mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HIBADH mRNA20106945
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of HIBADH mRNA]22228805
D004958EstradiolEstradiol affects the expression of HIBADH mRNA18214933
D004958EstradiolEstradiol results in decreased expression of HIBADH mRNA17522070
C044887beta-methylcholinebeta-methylcholine affects the expression of HIBADH mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of HIBADH mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HIBADH protein24527689
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of HIBADH mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of HIBADH mRNA17522070
D002725ChloroformChloroform results in decreased expression of HIBADH mRNA17522070
C041167chromium nitratechromium nitrate results in increased expression of HIBADH protein22144121
D002994ClofibrateClofibrate results in increased expression of HIBADH protein16470657
D003300CopperCopper affects the expression of HIBADH mRNA23825565
D003300CopperCopper results in decreased expression of HIBADH mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of HIBADH mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of HIBADH mRNA20106945
D003907DexamethasoneDexamethasone results in increased expression of HIBADH mRNA17522070
C000944dicrotophosdicrotophos results in decreased expression of HIBADH mRNA28302478
D004026DieldrinDieldrin results in decreased expression of HIBADH mRNA23153324
D004237DiuronDiuron results in decreased expression of HIBADH mRNA21551480
C118739entinostatentinostat results in increased expression of HIBADH mRNA27188386
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of HIBADH mRNA17522070
D000431EthanolEthanol results in decreased expression of HIBADH mRNA17920746
D005419FlavonoidsFlavonoids results in decreased expression of HIBADH mRNA18035473
D005485FlutamideFlutamide results in decreased expression of HIBADH mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of HIBADH mRNA23649840
D005897GlafenineGlafenine results in decreased expression of HIBADH mRNA24136188
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HIBADH mRNA25613284
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HIBADH mRNA23179753|2718838
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of HIBADH protein26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HIBADH mRNA23649840
D015741MetriboloneMetribolone results in decreased expression of HIBADH protein17152098
C044361M-VAC protocolHIBADH protein results in increased susceptibility to M-VAC protocol15814643
D009255NafenopinNafenopin results in increased expression of HIBADH protein10903494
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of HIBADH mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HIBADH mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of HIBADH mRNA17522070
D009532NickelNickel results in decreased expression of HIBADH mRNA25583101
D009585Nitrogen Dioxide[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of HIBADH gene27448387
D009585Nitrogen Dioxide[Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of HIBADH gene27448387
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HIBADH protein26879310
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HIBADH mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of HIBADH mRNA26272509
D010695PhlorhizinPhlorhizin results in decreased expression of HIBADH mRNA22538082
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of HIBADH protein22144121
D011374ProgesteroneProgesterone results in increased expression of HIBADH mRNA20726854
D011802QuinidineQuinidine results in increased expression of HIBADH mRNA17522070
C059514resveratrolresveratrol results in increased expression of HIBADH protein25505154
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HIBADH mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HIBADH mRNA19770486
D013752TetracyclineTetracycline results in decreased expression of HIBADH mRNA17522070
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HIBADH mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of HIBADH mRNA22378314
D013806TheophyllineTheophylline results in decreased expression of HIBADH mRNA17522070
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of HIBADH protein22595367|2260951
D014520UrethaneUrethane results in decreased expression of HIBADH mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of HIBADH mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HIBADH mRNA23179753|2915479
D014638VanadatesVanadates results in increased expression of HIBADH mRNA22714537
D014640VancomycinVancomycin results in increased expression of HIBADH mRNA18930951
D001335Vehicle Emissions[Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of HIBADH gene27448387
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of HIBADH gene25560391
C025643vinclozolinvinclozolin results in increased expression of HIBADH mRNA22570695
C029297vinylidene chloridevinylidene chloride results in decreased expression of HIBADH mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of HIBADH mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity-IEA-  
GO:00084423-hydroxyisobutyrate dehydrogenase activity-IBA21873635  
GO:00084423-hydroxyisobutyrate dehydrogenase activity-IDA16466957  
GO:00084423-hydroxyisobutyrate dehydrogenase activity-TAS-  
GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor-IBA21873635  
GO:0051287NAD binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006574valine catabolic process-IBA21873635  
GO:0006574valine catabolic process-IDA16466957  
GO:0006574valine catabolic process-IEA-  
GO:0009083branched-chain amino acid catabolic process-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00280Valine, leucine and isoleucine degradation
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70895Branched-chain amino acid catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24658151Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration. (2014)Wang YPLoS One