Gene: CIT

11113
CITK|CRIK|MCPH17|STK21
citron rho-interacting serine/threonine kinase
protein-coding
12q24.23
Ensembl:ENSG00000122966 MIM:605629 Vega:OTTHUMG00000134325 UniprotKB:O14578
NG_029792.1
PubMed|SNP Mapped
1   ANCO-SNPs
CD|OD|ND|AD
17   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.156e-1 (AD)  4.276e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs203339chr12:119798950 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTK2B0.944
PPFIA40.937
CELSR30.937
SIPA1L10.935
RAPGEFL10.933
KCNMA10.93
KIAA1211L0.929
IQSEC20.927
ARHGEF110.927
UNC5A0.927

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.531
RAI14-0.497
SGMS2-0.492
SNHG18-0.489
OR4F29-0.483
TFPI2-0.479
ANXA13-0.469
SH2D1A-0.463
C9orf135-0.463
HEY2-0.457

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of CIT mRNA25088246
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CIT mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CIT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CIT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CIT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CIT mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CIT mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of CIT mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CIT protein20106945
D000447AldehydesAldehydes results in decreased expression of CIT mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CIT mRNA16483693
D001151ArsenicArsenic affects the methylation of CIT gene25304211
C015001arsenitearsenite results in decreased expression of CIT mRNA18929588
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in increased expression of CIT mRNA17639512
D001280AtrazineAtrazine results in decreased expression of CIT mRNA27655631
D001379AzathioprineAzathioprine results in decreased expression of CIT mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CIT mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CIT mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CIT mRNA20504355
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CIT mRNA"20382639
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of CIT mRNA]25210133
D004958EstradiolEstradiol results in increased expression of CIT mRNA25210133
C006780bisphenol Abisphenol A results in increased expression of CIT mRNA24586524
C006780bisphenol Abisphenol A results in decreased methylation of CIT promoter27312807
C006780bisphenol Abisphenol A results in increased methylation of CIT promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of CIT mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of CIT protein24552547
C018475butyraldehydebutyraldehyde results in decreased expression of CIT mRNA26079696
D002104CadmiumCadmium results in decreased expression of CIT mRNA24376830
C018021cobaltous chloridecobaltous chloride results in decreased expression of CIT mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of CIT mRNA20971185
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of CIT mRNA19167446
C030973cupric oxidecupric oxide results in decreased expression of CIT mRNA22077320
D016572CyclosporineCyclosporine results in decreased expression of CIT mRNA21632981|2556210
C000944dicrotophosdicrotophos results in increased expression of CIT mRNA28302478
D004026DieldrinDieldrin affects the expression of CIT mRNA22546817
D002117CalcitriolCalcitriol results in decreased expression of CIT mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of CIT mRNA21592394
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of CIT mRNA24657277
C069837fullerene C60fullerene C60 results in decreased expression of CIT mRNA19167457
C039281furanfuran results in increased methylation of CIT gene22079235
D019833GenisteinGenistein affects the expression of CIT mRNA18847459
C544151jinfukangjinfukang results in increased expression of CIT mRNA27392435
C045463leflunomideleflunomide results in decreased expression of CIT mRNA28988120
D008154LucanthoneLucanthone results in decreased expression of CIT mRNA21148553
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of CIT mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of CIT mRNA24657277
D008727MethotrexateMethotrexate results in increased expression of CIT protein24736981
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CIT mRNA"20188158|2625132
C022838nickel chloridenickel chloride affects the expression of CIT mRNA22546817
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of CIT mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CIT mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of CIT mRNA25729387
D010416PentachlorophenolPentachlorophenol results in increased expression of CIT mRNA23892564
C046012pentanalpentanal results in decreased expression of CIT mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CIT mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CIT mRNA26272509
C005556propionaldehydepropionaldehyde results in decreased expression of CIT mRNA26079696
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in increased expression of CIT mRNA17639512
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of CIT mRNA19167446
C059514resveratrolresveratrol results in decreased expression of CIT protein18089832
D012834SilverSilver results in decreased expression of CIT mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of CIT mRNA16014739
D053260SootSoot results in increased expression of CIT mRNA26551751
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of CIT mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of CIT mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CIT mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CIT mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CIT mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CIT mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CIT mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CIT mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CIT mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of CIT mRNA19140230
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CIT mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of CIT mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of CIT gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CIT gene25560391
C025643vinclozolinvinclozolin affects the expression of CIT mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-ISS9792683  
GO:0005515protein binding-IPI16431929  
GO:0005524ATP binding-IEA-  
GO:0017048Rho GTPase binding-IEA-  
GO:0017124SH3 domain binding-IEA-  
GO:0030165PDZ domain binding-IDA17474715  
GO:0046872metal ion binding-IEA-  
GO:0097110scaffold protein binding-IDA17474715  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-IEA-  
GO:0000278mitotic cell cycle-ISS11086988  
GO:0000281mitotic cytokinesis-IMP16236794  27453578  
GO:0006468protein phosphorylation-IEA-  
GO:0007030Golgi organization-IEA-  
GO:0008064regulation of actin polymerization or depolymerization-IEA-  
GO:0032467positive regulation of cytokinesis-IMP16431929  
GO:0035556intracellular signal transduction-IEA-  
GO:0048699generation of neurons-ISS11086988  
GO:0051402neuron apoptotic process-IMP27453578  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0030496midbody-IEA-  
GO:0031985Golgi cisterna-IEA-  
GO:0032154cleavage furrow-IEA-  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194315Signaling by Rho GTPasesIEA
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-195258RHO GTPase EffectorsIEA
R-HSA-5625900RHO GTPases activate CITTAS
R-HSA-5625900RHO GTPases activate CITIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25757673Effect of extended-release naltrexone on striatal dopamine transporter availability, depression and anhedonia in heroin-dependent patients. (2015 Jul)Zaaijer ERPsychopharmacology (Berl)
23731497Low dopamine transporter occupancy by methylphenidate as a possible reason for reduced treatment effectiveness in ADHD patients with cocaine dependence. (2013 Dec)Crunelle CLEur Neuropsychopharmacol
17207098PET [11C]DASB imaging of serotonin transporters in patients with alcoholism. (2007 Jan)Brown AKAlcohol Clin Exp Res
9699688In vivo association between alcohol intoxication, aggression, and serotonin transporter availability in nonhuman primates. (1998 Aug)Heinz AAm J Psychiatry
15953494Deep serotonergic and dopaminergic structures in fetal alcoholic syndrome: a study with nor-beta-CIT-single-photon emission computed tomography and magnetic resonance imaging volumetry. (2005 Jun 15)Riikonen RSBiol Psychiatry
12163982Relationship between cortisol and serotonin metabolites and transporters in alcoholism [correction of alcolholism]. (2002 Jul)Heinz APharmacopsychiatry
28390775Deep Transcranial Magnetic Stimulation of the Dorsolateral Prefrontal Cortex in Alcohol Use Disorder Patients: Effects on Dopamine Transporter Availability and Alcohol Intake. (2017 May)Addolorato GEur Neuropsychopharmacol
19183998Serotonin transporter binding with [123I]beta-CIT SPECT in major depressive disorder versus controls: effect of season and gender. (2009 May)Ruhe HGEur J Nucl Med Mol Imaging
9513737Plasma homovanillic acid and the dopamine transporter during cocaine withdrawal. (1998 Feb 15)Bowers MB JrBiol Psychiatry
10873923Elevated central serotonin transporter binding availability in acutely abstinent cocaine-dependent patients. (2000 Jul)Jacobsen LKAm J Psychiatry
23434568The autoantibody repertoire in periodontitis: a role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis? (2014 Mar)de Pablo PAnn Rheum Dis
21797890Neuroendocrine assessment of serotonergic, dopaminergic, and noradrenergic functions in alcohol-dependent individuals. (2012 Jan)Fahlke CAlcohol Clin Exp Res
29237149Association of Antibodies to Citrullinated Protein Antigens with Blood Pressure in First-Degree Relatives of Rheumatoid Arthritis Patients: The Studies of the Etiology of Rheumatoid Arthritis. (2017)Hughes-Austin JMAm J Nephrol
10649826Genotype influences in vivo dopamine transporter availability in human striatum. (2000 Feb)Heinz ANeuropsychopharmacology
28339021Determinants of serum manganese levels in an Italian population. (2017 May)Filippini TMol Med Rep
12610656Serotonin transporter availability correlates with alcohol intake in non-human primates. (2003 Feb)Heinz AMol Psychiatry
25586403Subchronic administration of short-acting naltrexone has no effect on striatal dopamine transporter availability, food intake or body weight gain in rats. (2015 Mar)Zaaijer ERJ Psychopharmacol