Gene info: ID 11117

Gene: EMILIN1

GENE ID: 11117

Synonyms: EMI|EMILIN|gp115

Description: elastin microfibril interfacer 1

Gene type: protein-coding

Location: 2p23.3

dbXrefs: Ensembl:ENSG00000138080 MIM:130660 Vega:OTTHUMG00000097069 UniprotKB:Q9Y6C2

RefSeq: NG_046849.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.479e-1 (AD) 2.300e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EMP3	0.855
PLCB3	0.854
PRICKLE3	0.845
ARHGEF40	0.835
SYDE1	0.827
FCGRT	0.826
FLT3LG	0.826
CHST14	0.825
SH3BP2	0.824
DOK1	0.823

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PPEF1	-0.514
KCNB2	-0.512
PTPRR	-0.487
CDH8	-0.478
ABCC12	-0.477
SLC7A4	-0.477
GPR61	-0.472
SMIM18	-0.472
TYRP1	-0.471
EPHA5	-0.467

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of EMILIN1 mRNA"	21346803
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of EMILIN1 mRNA"	22863853
C547126	AZM551248	AZM551248 results in decreased expression of EMILIN1 mRNA	22323515
C547126	AZM551248	AZM551248 results in increased expression of EMILIN1 mRNA	22323515
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of EMILIN1 mRNA	19737606
C006780	bisphenol A	bisphenol A results in increased expression of EMILIN1 mRNA	25181051\|2717856
C006780	bisphenol A	bisphenol A results in increased methylation of EMILIN1 gene	28505145
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide affects the expression of EMILIN1 mRNA	23410634
C018475	butyraldehyde	butyraldehyde results in decreased expression of EMILIN1 mRNA	26079696
D060729	Coal Ash	Coal Ash results in increased expression of EMILIN1 mRNA	19000753
D003471	Cuprizone	Cuprizone results in increased expression of EMILIN1 mRNA	26577399
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of EMILIN1 mRNA	21266533
D002945	Cisplatin	Cisplatin results in increased expression of EMILIN1 mRNA	27594783
D004237	Diuron	Diuron results in increased expression of EMILIN1 mRNA	21551480
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of EMILIN1 mRNA	24534155
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EMILIN1 mRNA	17942748
D005557	Formaldehyde	Formaldehyde results in decreased expression of EMILIN1 mRNA	23649840
D005897	Glafenine	Glafenine results in increased expression of EMILIN1 mRNA	24136188
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of EMILIN1 mRNA	22634610
D017313	Fenretinide	Fenretinide results in increased expression of EMILIN1 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of EMILIN1 mRNA	23410634
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of EMILIN1 mRNA	23430699
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of EMILIN1 mRNA	25982114
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of EMILIN1 mRNA	23649840
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of EMILIN1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of EMILIN1 mRNA"	25554681
C051752	nefazodone	nefazodone results in decreased expression of EMILIN1 mRNA	24136188
C028007	nickel monoxide	nickel monoxide results in increased expression of EMILIN1 mRNA	19167457
D009966	Orphenadrine	Orphenadrine affects the expression of EMILIN1 mRNA	23665939
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of EMILIN1 mRNA	25729387
C016030	pantogab	pantogab results in increased expression of EMILIN1 mRNA	17379144
D011374	Progesterone	Progesterone results in decreased expression of EMILIN1 mRNA	23012394
D011441	Propylthiouracil	Propylthiouracil results in increased expression of EMILIN1 mRNA	24780913
D012643	Selenium	Selenium results in increased expression of EMILIN1 mRNA	19244175
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of EMILIN1 mRNA"	21514415
C009277	sodium arsenate	sodium arsenate results in decreased expression of EMILIN1 mRNA	21795629
D012999	Soman	Soman results in increased expression of EMILIN1 mRNA	19281266
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of EMILIN1 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of EMILIN1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EMILIN1 mRNA	17942748
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of EMILIN1 mRNA	25729387
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of EMILIN1 gene	27618143
C012589	trichostatin A	trichostatin A results in decreased expression of EMILIN1 mRNA	15901671
D014635	Valproic Acid	Valproic Acid results in increased methylation of EMILIN1 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of EMILIN1 mRNA	17292431\|1796380
D014635	Valproic Acid	Valproic Acid results in decreased expression of EMILIN1 mRNA	15901671
D014640	Vancomycin	Vancomycin results in decreased expression of EMILIN1 mRNA	18930951
C025643	vinclozolin	vinclozolin results in decreased expression of EMILIN1 mRNA	20566332
D014810	Vitamin E	Vitamin E results in increased expression of EMILIN1 mRNA	19244175
D024483	Vitamin K 3	Vitamin K 3 affects the expression of EMILIN1 mRNA	23410634

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	11278945 16189514 19447967 21516116 25416956 26627825
GO:0030023	extracellular matrix constituent conferring elasticity	-	IBA	21873635
GO:0042802	identical protein binding	-	IMP	18463100
GO:0042802	identical protein binding	-	IPI	10821830 25416956
GO:0098640	integrin binding involved in cell-matrix adhesion	-	IMP	18463100

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003180	aortic valve morphogenesis	-	ISS	-
GO:0007155	cell adhesion	-	TAS	10358019
GO:0007160	cell-matrix adhesion	-	IMP	18463100
GO:0010628	positive regulation of gene expression	-	ISS	-
GO:0010629	negative regulation of gene expression	-	ISS	-
GO:0010811	positive regulation of cell-substrate adhesion	-	IBA	21873635
GO:0010811	positive regulation of cell-substrate adhesion	-	IEA	-
GO:0016477	cell migration	-	IMP	18463100
GO:0016525	negative regulation of angiogenesis	-	ISS	-
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	-	ISS	-
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	-	ISS	-
GO:0045892	negative regulation of transcription, DNA-templated	-	ISS	-
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	-
GO:0048251	elastic fiber assembly	-	ISS	-
GO:0050866	negative regulation of cell activation	-	ISS	-
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	-	ISS	-
GO:0070207	protein homotrimerization	-	IMP	18463100
GO:0070373	negative regulation of ERK1 and ERK2 cascade	-	ISS	-
GO:1901203	positive regulation of extracellular matrix assembly	-	IEA	-
GO:1904027	negative regulation of collagen fibril organization	-	IEA	-
GO:1905522	negative regulation of macrophage migration	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005581	collagen trimer	-	IEA	-
GO:0005615	extracellular space	-	IMP	26462740
GO:0031012	extracellular matrix	-	HDA	23658023
GO:0031012	extracellular matrix	-	IBA	21873635
GO:0031012	extracellular matrix	-	IMP	26462740
GO:0034668	integrin alpha4-beta1 complex	-	IMP	18463100
GO:0062023	collagen-containing extracellular matrix	-	HDA	23979707 27068509
GO:0062023	collagen-containing extracellular matrix	colocalizes_with	HDA	20551380
GO:0070062	extracellular exosome	-	HDA	21362503
GO:1990971	EMILIN complex	-	IMP	18463100

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1474244	Extracellular matrix organization	IEA
R-HSA-1566948	Elastic fibre formation	TAS
R-HSA-1566948	Elastic fibre formation	IEA
R-HSA-2129379	Molecules associated with elastic fibres	TAS
R-HSA-2129379	Molecules associated with elastic fibres	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29207374	Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936. (2017 Dec 1)	Harris SE	Aging (Albany NY)