Gene: EMILIN1

11117
EMI|EMILIN|gp115
elastin microfibril interfacer 1
protein-coding
2p23.3
Ensembl:ENSG00000138080 MIM:130660 Vega:OTTHUMG00000097069 UniprotKB:Q9Y6C2
NG_046849.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.479e-1 (AD)  2.300e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EMP30.855
PLCB30.854
PRICKLE30.845
ARHGEF400.835
SYDE10.827
FCGRT0.826
FLT3LG0.826
CHST140.825
SH3BP20.824
DOK10.823

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPEF1-0.514
KCNB2-0.512
PTPRR-0.487
CDH8-0.478
ABCC12-0.477
SLC7A4-0.477
GPR61-0.472
SMIM18-0.472
TYRP1-0.471
EPHA5-0.467

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of EMILIN1 mRNA"21346803
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of EMILIN1 mRNA"22863853
C547126AZM551248AZM551248 results in decreased expression of EMILIN1 mRNA22323515
C547126AZM551248AZM551248 results in increased expression of EMILIN1 mRNA22323515
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of EMILIN1 mRNA19737606
C006780bisphenol Abisphenol A results in increased expression of EMILIN1 mRNA25181051|2717856
C006780bisphenol Abisphenol A results in increased methylation of EMILIN1 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of EMILIN1 mRNA23410634
C018475butyraldehydebutyraldehyde results in decreased expression of EMILIN1 mRNA26079696
D060729Coal AshCoal Ash results in increased expression of EMILIN1 mRNA19000753
D003471CuprizoneCuprizone results in increased expression of EMILIN1 mRNA26577399
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EMILIN1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of EMILIN1 mRNA27594783
D004237DiuronDiuron results in increased expression of EMILIN1 mRNA21551480
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of EMILIN1 mRNA24534155
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EMILIN1 mRNA17942748
D005557FormaldehydeFormaldehyde results in decreased expression of EMILIN1 mRNA23649840
D005897GlafenineGlafenine results in increased expression of EMILIN1 mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of EMILIN1 mRNA22634610
D017313FenretinideFenretinide results in increased expression of EMILIN1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of EMILIN1 mRNA23410634
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EMILIN1 mRNA23430699
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EMILIN1 mRNA25982114
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EMILIN1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of EMILIN1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EMILIN1 mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of EMILIN1 mRNA24136188
C028007nickel monoxidenickel monoxide results in increased expression of EMILIN1 mRNA19167457
D009966OrphenadrineOrphenadrine affects the expression of EMILIN1 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of EMILIN1 mRNA25729387
C016030pantogabpantogab results in increased expression of EMILIN1 mRNA17379144
D011374ProgesteroneProgesterone results in decreased expression of EMILIN1 mRNA23012394
D011441PropylthiouracilPropylthiouracil results in increased expression of EMILIN1 mRNA24780913
D012643SeleniumSelenium results in increased expression of EMILIN1 mRNA19244175
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of EMILIN1 mRNA"21514415
C009277sodium arsenatesodium arsenate results in decreased expression of EMILIN1 mRNA21795629
D012999SomanSoman results in increased expression of EMILIN1 mRNA19281266
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of EMILIN1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EMILIN1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EMILIN1 mRNA17942748
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of EMILIN1 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased methylation of EMILIN1 gene27618143
C012589trichostatin Atrichostatin A results in decreased expression of EMILIN1 mRNA15901671
D014635Valproic AcidValproic Acid results in increased methylation of EMILIN1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of EMILIN1 mRNA17292431|1796380
D014635Valproic AcidValproic Acid results in decreased expression of EMILIN1 mRNA15901671
D014640VancomycinVancomycin results in decreased expression of EMILIN1 mRNA18930951
C025643vinclozolinvinclozolin results in decreased expression of EMILIN1 mRNA20566332
D014810Vitamin EVitamin E results in increased expression of EMILIN1 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of EMILIN1 mRNA23410634

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11278945  16189514  19447967  21516116  25416956  26627825  
GO:0030023extracellular matrix constituent conferring elasticity-IBA21873635  
GO:0042802identical protein binding-IMP18463100  
GO:0042802identical protein binding-IPI10821830  25416956  
GO:0098640integrin binding involved in cell-matrix adhesion-IMP18463100  
GO ID GO Term Qualifier Evidence PubMed
GO:0003180aortic valve morphogenesis-ISS-  
GO:0007155cell adhesion-TAS10358019  
GO:0007160cell-matrix adhesion-IMP18463100  
GO:0010628positive regulation of gene expression-ISS-  
GO:0010629negative regulation of gene expression-ISS-  
GO:0010811positive regulation of cell-substrate adhesion-IBA21873635  
GO:0010811positive regulation of cell-substrate adhesion-IEA-  
GO:0016477cell migration-IMP18463100  
GO:0016525negative regulation of angiogenesis-ISS-  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-ISS-  
GO:0030948negative regulation of vascular endothelial growth factor receptor signaling pathway-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0048251elastic fiber assembly-ISS-  
GO:0050866negative regulation of cell activation-ISS-  
GO:0060394negative regulation of pathway-restricted SMAD protein phosphorylation-ISS-  
GO:0070207protein homotrimerization-IMP18463100  
GO:0070373negative regulation of ERK1 and ERK2 cascade-ISS-  
GO:1901203positive regulation of extracellular matrix assembly-IEA-  
GO:1904027negative regulation of collagen fibril organization-IEA-  
GO:1905522negative regulation of macrophage migration-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005581collagen trimer-IEA-  
GO:0005615extracellular space-IMP26462740  
GO:0031012extracellular matrix-HDA23658023  
GO:0031012extracellular matrix-IBA21873635  
GO:0031012extracellular matrix-IMP26462740  
GO:0034668integrin alpha4-beta1 complex-IMP18463100  
GO:0062023collagen-containing extracellular matrix-HDA23979707  27068509  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0070062extracellular exosome-HDA21362503  
GO:1990971EMILIN complex-IMP18463100  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1566948Elastic fibre formationTAS
R-HSA-1566948Elastic fibre formationIEA
R-HSA-2129379Molecules associated with elastic fibresTAS
R-HSA-2129379Molecules associated with elastic fibresIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29207374Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936. (2017 Dec 1)Harris SEAging (Albany NY)