Gene: BTN2A1

11120
BK14H9.1|BT2.1|BTF1|BTN2.1|DJ3E1.1
butyrophilin subfamily 2 member A1
protein-coding
6p22.2
Ensembl:ENSG00000112763 MIM:613590 Vega:OTTHUMG00000014457 UniprotKB:Q7KYR7
NC_000006.12
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  9.853e-2 (ND)   (Frontal_Cortex)
8.741e-2 (AD)  6.979e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF1450.918
RNF19B0.912
PRDM40.905
SF3A30.904
B4GALT50.904
TOX40.903
M6PR0.901
NOLC10.899
GRB20.897
ADAR0.896

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.54
OR4F29-0.517
PON1-0.354
OLAH-0.311
MTRNR2L6-0.308
ASB4-0.306
ENDOU-0.304
DIAPH3-0.302
MTRNR2L10-0.302
NXNL1-0.301

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of BTN2A1 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of BTN2A1 mRNA24449571
D001104ArbutinArbutin results in decreased expression of BTN2A1 mRNA17103032
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BTN2A1 mRNA21632981
C044887beta-methylcholinebeta-methylcholine affects the expression of BTN2A1 mRNA21179406
C018475butyraldehydebutyraldehyde results in increased expression of BTN2A1 mRNA26079696
D002104CadmiumCadmium results in decreased expression of BTN2A1 mRNA24376830
D016572CyclosporineCyclosporine results in increased expression of BTN2A1 mRNA20106945|2556210
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of BTN2A1 mRNA27392435
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of BTN2A1 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of BTN2A1 mRNA23649840
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of BTN2A1 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of BTN2A1 mRNA23649840
C046012pentanalpentanal results in increased expression of BTN2A1 mRNA26079696
C014153pirimiphos methylpirimiphos methyl results in increased expression of BTN2A1 mRNA27845199
D014284TriiodothyronineTriiodothyronine results in decreased expression of BTN2A1 mRNA23397585
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of BTN2A1 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BTN2A1 mRNA"26179874
D014520UrethaneUrethane results in increased expression of BTN2A1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of BTN2A1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of BTN2A1 mRNA23179753|2800136

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005102signaling receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001817regulation of cytokine production-IBA21873635  
GO:0006629lipid metabolic process-TAS9382921  
GO:0050776regulation of immune response-IBA21873635  
GO:0050852T cell receptor signaling pathway-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9382921  
GO:0009897external side of plasma membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-8851680Butyrophilin (BTN) family interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21672009Association of a polymorphism of BTN2A1 with type 2 diabetes mellitus in Japanese individuals. (2011 Nov)Hiramatsu MDiabet Med
25813534Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study. (2015 May)Yamada YInt J Mol Med
25279152Association of a butyrophilin, subfamily 2, member A1 gene polymorphism with hypertension. (2014 Nov)Murakata YBiomed Rep
24452779Association of a polymorphism of BTN2A1 with dyslipidemia in community-dwelling individuals. (2014 Mar)Horibe HMol Med Rep