Gene: PTPRT

11122
RPTPrho
protein tyrosine phosphatase, receptor type T
protein-coding
20q12-q13.11
Ensembl:ENSG00000196090 MIM:608712 Vega:OTTHUMG00000033040 UniprotKB:O14522
NG_033880.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.423e-1 (AD)  2.619e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11086862chr20:43125961 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HECW10.978
AAK10.966
OPCML0.962
SV2B0.961
ZNF385B0.96
PRKCE0.96
STXBP5L0.959
ATP8A20.959
DLGAP10.958
ADD20.958

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.604
RAB13-0.581
YES1-0.575
REST-0.572
COPZ2-0.571
RAI14-0.563
RNF135-0.549
MYL3-0.545
WWTR1-0.541
AGTRAP-0.54

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PTPRT mRNA"28973690
D000082AcetaminophenAcetaminophen affects the expression of PTPRT mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PTPRT mRNA23630614
C547126AZM551248AZM551248 results in decreased expression of PTPRT mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of PTPRT gene25435355
C006780bisphenol Abisphenol A affects the expression of PTPRT mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of PTPRT gene28505145
C006780bisphenol Abisphenol A results in decreased expression of PTPRT mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PTPRT gene28505145
C029892cupric chloridecupric chloride results in decreased expression of PTPRT mRNA24650576
D004041Dietary Fats[Streptozocin co-treated with Dietary Fats] results in decreased expression of PTPRT mRNA20665664
D019422Dietary SucroseDietary Sucrose results in increased expression of PTPRT mRNA26033743
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of PTPRT mRNA22129741
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of PTPRT mRNA"27840820
D004397FonofosFonofos results in increased methylation of PTPRT promoter22847954
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of PTPRT gene28505145
C016517indole-3-carbinolindole-3-carbinol affects the expression of PTPRT mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of PTPRT mRNA22129741
D007213IndomethacinIndomethacin results in decreased expression of PTPRT mRNA28201806
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PTPRT mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PTPRT mRNA"20188158
D010278ParathionParathion results in increased methylation of PTPRT promoter22847954
C006253pirinixic acidpirinixic acid results in increased expression of PTPRT mRNA20813756
D011441PropylthiouracilPropylthiouracil results in increased expression of PTPRT mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PTPRT mRNA23806026
D013311Streptozocin[Streptozocin co-treated with Dietary Fats] results in decreased expression of PTPRT mRNA20665664
C012568terbufosterbufos results in increased methylation of PTPRT promoter22847954
D014212TretinoinTretinoin results in decreased expression of PTPRT mRNA23724009
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PTPRT gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004725protein tyrosine phosphatase activity-IMP16973135  17360477  
GO:0005515protein binding-IPI16273344  19816407  21725282  
GO:0008013beta-catenin binding-IPI16973135  
GO:0045294alpha-catenin binding-IDA16973135  
GO:0045295gamma-catenin binding-IDA16973135  
GO:0045296cadherin binding-IPI16973135  
GO:0070097delta-catenin binding-IPI16973135  
GO ID GO Term Qualifier Evidence PubMed
GO:0006470protein dephosphorylation-IDA16973135  
GO:0007155cell adhesion-NAS16973135  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IDA18644975  
GO:0007165signal transduction-NAS16973135  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IMP16973135  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA18644975  
GO:0009986cell surface-IDA18644975  
GO:0016021integral component of membrane-NAS9602027  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25967969The Functional Variant in the 3'UTR of PTPRT with the Risk of Esophageal Squamous Cell Carcinoma in a Chinese Population. (2015)Yao YCell Physiol Biochem