Gene: FAF1

11124
CGI-03|HFAF1s|UBXD12|UBXN3A|hFAF1
Fas associated factor 1
protein-coding
1p32.3
Ensembl:ENSG00000185104 MIM:604460 Vega:OTTHUMG00000007930 UniprotKB:Q9UNN5
NC_000001.11
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.003e-1 (AD)  2.676e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11205760chr1:50708658 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3827730chr1:50472176 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4381241chr1:50441766 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRPC4AP0.947
SUPT16H0.937
EXOC10.935
TMEM30A0.933
MAGED20.931
DCAF80.931
CKAP50.93
WBP110.93
RAB140.929
C6orf890.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.72
OR4F29-0.685
MTRNR2L6-0.33
MTRNR2L9-0.324
MTRNR2L10-0.306
TTLL10-0.277
MTRNR2L2-0.262
MTRNR2L8-0.262
KLRB1-0.251
CSAG1-0.248

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FAF1 mRNA"22698814
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FAF1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FAF1 mRNA"16917068
C0164032,4-dinitrotoluene"2,4-dinitrotoluene results in decreased expression of FAF1 mRNA"16917068
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FAF1 mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 affects the expression of FAF1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FAF1 mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FAF1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FAF1 mRNA16483693
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of FAF1 mRNA"17331233
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of FAF1 mRNA"19223589
D017638Asbestos, Crocidolite"[CDKN2A mRNA alternative form affects the susceptibility to Asbestos, Crocidolite] which affects the expression of FAF1 mRNA"19223589
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FAF1 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FAF1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FAF1 mRNA22300585
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FAF1 mRNA"20382639|2623829
C006780bisphenol Abisphenol A affects the expression of FAF1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of FAF1 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of FAF1 mRNA17895889
D002104CadmiumCadmium results in increased expression of FAF1 mRNA26187450
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FAF1 mRNA19031917
D016572CyclosporineCyclosporine results in increased expression of FAF1 mRNA20106945|2556210
D064730Dexrazoxane[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of FAF1 mRNA26873546
D003976DiazinonDiazinon affects the expression of FAF1 mRNA22546817
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of FAF1 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of FAF1 mRNA19561079
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of FAF1 mRNA]27392435
D004026DieldrinDieldrin affects the expression of FAF1 mRNA22546817
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of FAF1 mRNA"22485181
D004317Doxorubicin[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of FAF1 mRNA26873546
D004317DoxorubicinDoxorubicin results in increased expression of FAF1 mRNA26873546
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of FAF1 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FAF1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FAF1 mRNA17942748
C024565ethylene dichlorideethylene dichloride results in increased expression of FAF1 mRNA28189721
D005485FlutamideFlutamide results in increased expression of FAF1 mRNA21126777
D005485FlutamideFlutamide results in increased expression of FAF1 mRNA24136188
D017313FenretinideFenretinide results in decreased expression of FAF1 mRNA16570282
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of FAF1 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of FAF1 mRNA]27392435
D007654KetoconazoleKetoconazole results in increased expression of FAF1 mRNA25808816
D007654KetoconazoleKetoconazole results in increased expression of FAF1 mRNA25808816
D048628KetolidesKetolides analog results in decreased expression of FAF1 mRNA24967691
D007854LeadLead results in decreased expression of FAF1 mRNA19921347
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FAF1 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of FAF1 protein26558463
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of FAF1 protein26558463
D009151Mustard GasMustard Gas results in decreased expression of FAF1 mRNA25102026
C051752nefazodonenefazodone results in increased expression of FAF1 mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of FAF1 mRNA25729387
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of FAF1 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of FAF1 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of FAF1 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of FAF1 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of FAF1 mRNA]17655762
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of FAF1 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of FAF1 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of FAF1 mRNA]17655762
D010416PentachlorophenolPentachlorophenol results in increased expression of FAF1 mRNA23892564
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of FAF1 mRNA28973697
C043680ptaquilosideptaquiloside results in decreased expression of FAF1 mRNA23274088
C116926rofecoxibrofecoxib affects the expression of FAF1 mRNA17070997
D018038Sodium SeleniteSodium Selenite results in increased expression of FAF1 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FAF1 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FAF1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FAF1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FAF1 mRNA21215274
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of FAF1 mRNA16137721
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of FAF1 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of FAF1 mRNA19448997
D014415TunicamycinTunicamycin results in increased expression of FAF1 mRNA22378314
D014520UrethaneUrethane results in increased expression of FAF1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of FAF1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of FAF1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of FAF1 mRNA23179753|2915479
D014635Valproic AcidValproic Acid affects the expression of FAF1 mRNA17292431
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of FAF1 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of FAF1 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of FAF1 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the methylation of FAF1 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of FAF1 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15688372  15743842  26842564  
GO:0019887protein kinase regulator activity-NAS11713579  
GO:0019901protein kinase binding-IDA11713579  
GO:0019904protein domain specific binding-IEA-  
GO:0031072heat shock protein binding-IDA15596450  
GO:0031625ubiquitin protein ligase binding-IDA18775313  
GO:0043130ubiquitin binding-IDA18775313  
GO:0051059NF-kappaB binding-IPI14600157  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0007253cytoplasmic sequestering of NF-kappaB-IMP14600157  
GO:0008219cell death-IMP15743842  
GO:0010942positive regulation of cell death-IDA15596450  
GO:0030155regulation of cell adhesion-IEA-  
GO:0031334positive regulation of protein complex assembly-IMP15688372  
GO:0042176regulation of protein catabolic process-IMP15743842  
GO:0043065positive regulation of apoptotic process-NAS10462485  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-NAS15743842  
GO:0045740positive regulation of DNA replication-IMP26842564  
GO:0045859regulation of protein kinase activity-IEA-  
GO:1902043positive regulation of extrinsic apoptotic signaling pathway via death domain receptors-IEA-  
GO:1903364positive regulation of cellular protein catabolic process-IMP26842564  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA15596450  26842564  
GO:0005635nuclear envelope-IEA-  
GO:0005829cytosol-IDA15596450  
GO:0031265CD95 death-inducing signaling complex-NAS12702723  
GO:0034098VCP-NPL4-UFD1 AAA ATPase complex-IDA18775313  
GO:0048471perinuclear region of cytoplasm-IDA11713579  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal