Gene: CHGA

1113
CGA
chromogranin A
protein-coding
14q32.12
Ensembl:ENSG00000100604 MIM:118910 Vega:OTTHUMG00000171225 UniprotKB:P10645
NC_000014.9
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.488e-1 (AD)  3.603e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNM10.954
UNC5A0.952
PRKAR1B0.948
FSD10.946
APBA20.944
SYN10.942
KLC20.942
EPHB60.94
RBFOX30.937
SV2A0.933

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.528
LRAT-0.52
OR4F29-0.497
REST-0.496
ARHGEF5-0.491
RAI14-0.488
TFPI2-0.482
MBNL3-0.479
WWTR1-0.467
YES1-0.464

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of CHGA mRNA"20206263
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHGA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHGA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHGA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHGA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHGA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHGA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHGA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHGA mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CHGA mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of CHGA mRNA17562736
D000108Acetylcarnitine[Acetylcarnitine co-treated with NGF protein] results in increased expression of CHGA mRNA14654561
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CHGA gene27153756
D000638AmiodaroneAmiodarone results in increased expression of CHGA mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHGA mRNA16483693
D001280AtrazineAtrazine results in decreased expression of CHGA mRNA22378314
D001374AzacitidineAzacitidine results in decreased expression of CHGA protein20607034
C049708B 823-08B 823-08 results in increased expression of CHGA mRNA7569754
C049708B 823-08PD 136450 inhibits the reaction [B 823-08 results in increased expression of CHGA mRNA]7569754
C487081belinostatbelinostat results in increased expression of CHGA mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHGA mRNA"27188386
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of CHGA mRNA17404688
C044887beta-methylcholinebeta-methylcholine affects the expression of CHGA mRNA21179406
C006780bisphenol Abisphenol A affects the expression of CHGA mRNA20170705
C006780bisphenol Abisphenol A affects the expression of CHGA mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CHGA mRNA25181051
D002104CadmiumCadmium results in increased expression of CHGA mRNA21694771
C062876cetrorelix[cetrorelix co-treated with testosterone enanthate] results in decreased expression of CHGA mRNA18160741
D002714ChlorisondamineChlorisondamine inhibits the reaction [Nicotine results in increased activity of CHGA promoter]12799369
D002714ChlorisondamineChlorisondamine inhibits the reaction [Reserpine results in increased activity of CHGA promoter]12799369
D004390ChlorpyrifosChlorpyrifos affects the expression of CHGA mRNA18812211
D004390ChlorpyrifosChlorpyrifos results in increased expression of CHGA mRNA17452286
D003024ClozapineClozapine results in decreased expression of CHGA mRNA12437575
D003024ClozapineClozapine results in increased expression of CHGA mRNA12437575
D003024ClozapineClozapine results in decreased expression of CHGA mRNA10869885
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of CHGA mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of CHGA mRNA19549813
D003520CyclophosphamideCyclophosphamide results in decreased expression of CHGA mRNA15331540
D003976DiazinonDiazinon results in increased expression of CHGA mRNA17452286
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CHGA mRNA25607892
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CHGA mRNA25607892
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CHGA mRNA25607892
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of CHGA mRNA24690739
C012301domoic aciddomoic acid results in increased expression of CHGA mRNA18936300
C118739entinostatentinostat results in increased expression of CHGA mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHGA mRNA"27188386
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CHGA mRNA25607892
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CHGA mRNA20170705
C039281furanfuran results in increased expression of CHGA mRNA27387713
C039281furanfuran results in increased methylation of CHGA gene22079235
D005665FurosemideFurosemide results in increased expression of CHGA mRNA16526316
D007052IbuprofenIbuprofen results in increased expression of CHGA mRNA28201806
D007854LeadLead affects the expression of CHGA mRNA28903495
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CHGA mRNA25607892
C015329lycopenelycopene results in increased expression of CHGA mRNA16886892
D008731MethoxychlorMethoxychlor results in increased methylation of CHGA gene23303685
D008774MethylphenidateMethylphenidate results in decreased expression of CHGA mRNA22470460
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CHGA mRNA16026605
C010463n-hexanaln-hexanal results in increased expression of CHGA mRNA26403475
D009532NickelNickel affects the expression of CHGA mRNA18812211
D009538NicotineCHGA protein alternative form inhibits the reaction [Nicotine results in increased activity of CHGA promoter]12799369|1279936
D009538NicotineChlorisondamine inhibits the reaction [Nicotine results in increased activity of CHGA promoter]12799369
D009538NicotineNicotine results in increased activity of CHGA promoter12799369
D009538NicotineNicotine results in increased expression of CHGA mRNA1907749
D010095OxotremorineOxotremorine results in increased expression of CHGA mRNA1907749
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHGA mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of CHGA mRNA26272509
C077645PD 136450PD 136450 inhibits the reaction [B 823-08 results in increased expression of CHGA mRNA]7569754
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHGA mRNA"27188386
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CHGA mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CHGA mRNA25607892
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of CHGA mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of CHGA mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of CHGA mRNA19690047
D011441PropylthiouracilPropylthiouracil results in decreased expression of CHGA mRNA24780913
D012110ReserpineCHGA protein alternative form inhibits the reaction [Reserpine results in increased activity of CHGA promoter]12799369|1279936
D012110ReserpineChlorisondamine inhibits the reaction [Reserpine results in increased activity of CHGA promoter]12799369
D012110ReserpineReserpine results in increased activity of CHGA promoter12799369
D012110ReserpineReserpine results in increased expression of CHGA mRNA1907749|8189248
C059514resveratrolresveratrol results in decreased expression of CHGA protein21184191
D018967RisperidoneRisperidone results in decreased expression of CHGA mRNA10869885
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CHGA mRNA21427059
C541923sandostatinLARsandostatinLAR results in decreased expression of CHGA mRNA17210224
D012715Sesame OilSesame Oil results in decreased expression of CHGA mRNA29191790
D018038Sodium SeleniteSodium Selenite results in increased expression of CHGA mRNA18175754
C004648testosterone enanthate[cetrorelix co-treated with testosterone enanthate] results in decreased expression of CHGA mRNA18160741
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CHGA mRNA17942748
D019284ThapsigarginThapsigargin results in decreased expression of CHGA mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CHGA mRNA27404394
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CHGA mRNA28111298
D014212TretinoinTretinoin results in decreased expression of CHGA mRNA21934132
D014415TunicamycinTunicamycin results in decreased expression of CHGA mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of CHGA mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CHGA mRNA24383497|2800136
D014635Valproic AcidValproic Acid results in increased expression of CHGA mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CHGA gene25560391
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CHGA mRNA25607892
D015034Zinc OxideZinc Oxide analog results in decreased expression of CHGA mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of CHGA mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0002026regulation of the force of heart contraction-ISS-  
GO:0002551mast cell chemotaxis-IDA21214543  
GO:0006996organelle organization-ISS-  
GO:0008217regulation of blood pressure-TAS8406464  
GO:0019730antimicrobial humoral response-TAS-  
GO:0031640killing of cells of other organism-IEA-  
GO:0032762mast cell cytokine production-IDA21214543  
GO:0033604negative regulation of catecholamine secretion-IBA21873635  
GO:0033604negative regulation of catecholamine secretion-IDA15326220  
GO:0042742defense response to bacterium-IBA21873635  
GO:0043303mast cell degranulation-IDA21214543  
GO:0045087innate immune response-NAS15723172  
GO:0045576mast cell activation-IDA21214543  
GO:0046676negative regulation of insulin secretion-IBA21873635  
GO:0046888negative regulation of hormone secretion-IBA21873635  
GO:0050829defense response to Gram-negative bacterium-IDA15723172  
GO:0050830defense response to Gram-positive bacterium-IDA15723172  
GO:0050832defense response to fungus-IEA-  
GO:0060452positive regulation of cardiac muscle contraction-ISS-  
GO:0086030adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation-IBA21873635  
GO:0086030adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation-ISS-  
GO:0097756negative regulation of blood vessel diameter-ISS-  
GO:1900738positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway-ISS-  
GO:1901215negative regulation of neuron death-ISS-  
GO:1901899positive regulation of relaxation of cardiac muscle-ISS-  
GO:2000707positive regulation of dense core granule biogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-ISS-  
GO:0030141secretory granule-IBA21873635  
GO:0030141secretory granule-ISS-  
GO:0030658transport vesicle membrane-IEA-  
GO:0042583chromaffin granule-IBA21873635  
GO:0042583chromaffin granule-ISS-  
GO:0042629mast cell granule-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA20862257  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6803157Antimicrobial peptidesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23599765Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer. (2013 Apr)Zhao YOncol Lett
20413096Neuroendocrine nicotinic receptor activation increases susceptibility to bacterial infections by suppressing antimicrobial peptide production. (2010 Apr 22)Radek KACell Host Microbe
23562218Nicotine in cigarettes promotes chromogranin A production by human periodontal ligament fibroblasts. (2013 Aug)Sadaoka SArch Oral Biol