Gene: CAPN10

11132
CANP10|NIDDM1
calpain 10
protein-coding
2q37.3
Ensembl:ENSG00000142330 MIM:605286 Vega:OTTHUMG00000133358 UniprotKB:Q9HC96
NG_011558.2
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.057e-1 (AD)  4.416e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MFSD100.898
BRAT10.897
TELO20.885
CACTIN0.884
SLC39A130.883
B4GALNT40.882
TRMT2A0.881
ARFRP10.88
RFNG0.876
PPP1R16A0.874

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.708
OR4F29-0.647
CNTF-0.313
DNASE1L3-0.309
MTRNR2L9-0.308
MTRNR2L6-0.307
PZP-0.299
SLC18A1-0.295
VNN2-0.293
C9orf153-0.288

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CAPN10 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CAPN10 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of CAPN10 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of CAPN10 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CAPN10 mRNA21641981
D001151ArsenicCAPN10 gene SNP affects the susceptibility to Arsenic23349674
C006632arsenic trioxidearsenic trioxide results in increased expression of CAPN10 mRNA15761015
C015001arsenitearsenite results in increased expression of CAPN10 mRNA18597805
C006780bisphenol Abisphenol A results in increased expression of CAPN10 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of CAPN10 mRNA24752500
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CAPN10 mRNA17602206
D003976DiazinonDiazinon results in increased methylation of CAPN10 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CAPN10 mRNA21266533
D004008DiclofenacDiclofenac affects the expression of CAPN10 mRNA24752500
D004041Dietary FatsDietary Fats results in decreased expression of CAPN10 mRNA18503570
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CAPN10 mRNA17602206
C024629dimethyl phthalatedimethyl phthalate affects the expression of CAPN10 mRNA26924002
D007545IsoproterenolIsoproterenol results in increased expression of CAPN10 mRNA20003209
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CAPN10 mRNA"25620056
D009538NicotineNicotine results in increased expression of CAPN10 mRNA17997037
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CAPN10 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CAPN10 mRNA18301758
D012999SomanSoman results in decreased expression of CAPN10 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CAPN10 mRNA21570461
D014212TretinoinTretinoin results in increased expression of CAPN10 mRNA17218384
D014520UrethaneUrethane results in increased expression of CAPN10 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of CAPN10 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CAPN10 gene25560391
D019287Zinc SulfateZinc Sulfate results in decreased expression of CAPN10 mRNA16330358

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000149SNARE binding-ISS-  
GO:0004198calcium-dependent cysteine-type endopeptidase activity-IBA21873635  
GO:0004198calcium-dependent cysteine-type endopeptidase activity-IMP15044459  
GO:0008092cytoskeletal protein binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-IMP15044459  
GO:0006921cellular component disassembly involved in execution phase of apoptosis-IC-  
GO:0031532actin cytoskeleton reorganization-ISS12974673  
GO:0032024positive regulation of insulin secretion-IMP15471947  
GO:0032388positive regulation of intracellular transport-ISS12974673  
GO:0032869cellular response to insulin stimulus-IMP17572128  
GO:0046326positive regulation of glucose import-IMP17572128  
GO:0097050type B pancreatic cell apoptotic process-IDA15044459  
GO:2000676positive regulation of type B pancreatic cell apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-IDA16790502  
GO:0005829cytosol-IDA16790502  
GO:0005829cytosol-ISS-  
GO:0005886plasma membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20667559Association of calpain 10 gene polymorphisms with type 2 diabetes mellitus in Southern Indians. (2011 May)Bodhini DMetabolism
20178008Association of diabetes susceptibility gene calpain-10 with pancreatic cancer among smokers. (2010 Sep)Fong PYJ Gastrointest Cancer