Gene: TBC1D8

11138
AD3|GRAMD8|HBLP1|TBC1D8A|VRP
TBC1 domain family member 8
protein-coding
2q11.2
Ensembl:ENSG00000204634 Vega:OTTHUMG00000153040 UniprotKB:O95759
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.526e-1 (AD)  8.007e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7608232chr2:101082601 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ETS20.773
SRGAP20.756
RPS6KA30.751
MGAT4A0.735
HEXB0.735
LRCH10.734
STX30.734
GMIP0.732
DENND30.728
SLC7A60.727

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DIAPH3-0.417
S100A1-0.381
ZFHX4-AS1-0.364
OR4F5-0.357
ACOX2-0.353
EYA2-0.343
OR4F29-0.339
HOGA1-0.334
NTSR2-0.329
SOX3-0.328

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TBC1D8 mRNA19933214
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of TBC1D8 mRNA"20406850
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of TBC1D8 mRNA16788091
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TBC1D8 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of TBC1D8 mRNA21420995|2906747
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TBC1D8 mRNA24449571
C015001arsenitearsenite results in decreased expression of TBC1D8 mRNA18929588
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TBC1D8 mRNA26238291
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of TBC1D8 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TBC1D8 mRNA19770486|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of TBC1D8 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TBC1D8 mRNA"19150397
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of TBC1D8 mRNA]24758408
D004958EstradiolEstradiol results in decreased expression of TBC1D8 mRNA24758408
C006780bisphenol Abisphenol A results in decreased expression of TBC1D8 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TBC1D8 gene28505145
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TBC1D8 mRNA23650126
C018021cobaltous chloridecobaltous chloride results in decreased expression of TBC1D8 mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of TBC1D8 mRNA19549813
D019327Copper SulfateCopper Sulfate results in decreased expression of TBC1D8 mRNA18579281
D003474CurcuminCurcumin results in increased expression of TBC1D8 mRNA17999991
D016572CyclosporineCyclosporine results in increased expression of TBC1D8 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of TBC1D8 mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TBC1D8 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TBC1D8 mRNA27392435
D002945CisplatinCisplatin results in increased expression of TBC1D8 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of TBC1D8 mRNA18042831
D002117CalcitriolCalcitriol results in increased expression of TBC1D8 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of TBC1D8 mRNA21592394
C118739entinostatentinostat results in decreased expression of TBC1D8 mRNA26272509
D000431EthanolEthanol results in decreased expression of TBC1D8 mRNA19167417
D005047EtoposideEtoposide results in increased expression of TBC1D8 mRNA25270620
D005485FlutamideFlutamide results in decreased expression of TBC1D8 mRNA24136188
D005897GlafenineGlafenine results in decreased expression of TBC1D8 mRNA24136188
D017313FenretinideFenretinide results in increased expression of TBC1D8 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TBC1D8 mRNA20044591
C016517indole-3-carbinolindole-3-carbinol affects the expression of TBC1D8 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TBC1D8 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TBC1D8 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TBC1D8 mRNA24796395
C410337K 7174K 7174 results in increased expression of TBC1D8 mRNA24086573
C045463leflunomideleflunomide results in increased expression of TBC1D8 mRNA24136188
D018021Lithium ChlorideLithium Chloride results in decreased expression of TBC1D8 mRNA15711924
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TBC1D8 mRNA28001369
D016685MitomycinMitomycin results in increased expression of TBC1D8 mRNA25270620
D008942MitoxantroneTBC1D8 protein affects the susceptibility to Mitoxantrone16217747
C051752nefazodonenefazodone results in decreased expression of TBC1D8 mRNA24136188
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TBC1D8 mRNA"12756304
D000073878Palm OilPalm Oil results in increased expression of TBC1D8 mRNA18042831
C496932panobinostatpanobinostat results in decreased expression of TBC1D8 mRNA26272509
C016030pantogabpantogab results in increased expression of TBC1D8 mRNA17379144
D010416PentachlorophenolPentachlorophenol results in increased expression of TBC1D8 mRNA23892564
C006253pirinixic acidpirinixic acid results in increased expression of TBC1D8 mRNA18445702
D011794QuercetinQuercetin results in increased expression of TBC1D8 mRNA21632981
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of TBC1D8 mRNA21427059
C017947sodium arsenitesodium arsenite affects the methylation of TBC1D8 gene28589171
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TBC1D8 mRNA"18579281
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of TBC1D8 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of TBC1D8 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TBC1D8 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBC1D8 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of TBC1D8 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TBC1D8 mRNA19770486|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TBC1D8 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TBC1D8 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TBC1D8 mRNA28065790
C012589trichostatin Atrichostatin A results in decreased expression of TBC1D8 mRNA26272509
D014520UrethaneUrethane results in increased expression of TBC1D8 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of TBC1D8 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TBC1D8 mRNA26272509|2800136
D014635Valproic AcidValproic Acid results in increased expression of TBC1D8 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of TBC1D8 mRNA21427059
C025643vinclozolinvinclozolin results in decreased expression of TBC1D8 mRNA23034163
D014752Vinyl ChlorideVinyl Chloride results in decreased expression of TBC1D8 mRNA18579281
D019287Zinc SulfateZinc Sulfate results in increased expression of TBC1D8 mRNA12756304
C088658zoledronic acidzoledronic acid results in increased expression of TBC1D8 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IBA21873635  
GO:0017137Rab GTPase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0008015blood circulation-TAS10373574  
GO:0008284positive regulation of cell proliferation-TAS10373574  
GO:0090630activation of GTPase activity-IBA21873635  
GO:1902017regulation of cilium assemblyNOTIMP17646400  
GO ID GO Term Qualifier Evidence PubMed
GO:0016020membrane-TAS10373574  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal