Gene: CHI3L1

1116
ASRT7|CGP-39|GP-39|GP39|HC-gp39|HCGP-3P|YKL-40|YKL40|YYL-40|hCGP-39
chitinase 3 like 1
protein-coding
1q32.1
Ensembl:ENSG00000133048 MIM:601525 Vega:OTTHUMG00000042122 UniprotKB:P36222
NG_013056.1
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.622e-1 (AD)  4.612e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg17000774chr1:203154457CHI3L1Gene body1.039e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SERPINA30.886
IGFLR10.814
LIMK20.8
C1R0.793
HSD3B70.793
MYBPH0.792
C4B0.789
TMBIM10.783
BCL60.774
CD440.774

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EDN3-0.469
HAPLN1-0.453
C1QTNF2-0.438
ACY3-0.423
AARD-0.407
KIT-0.403
IGF1-0.399
F7-0.389
OSTN-0.384
MARCH4-0.382

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CHI3L1 mRNA19933214
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in decreased expression of CHI3L1 protein]21029458
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of CHI3L1 mRNA"20206263
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHI3L1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHI3L1 mRNA"27188386
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of CHI3L1 mRNA"19936710
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHI3L1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CHI3L1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of CHI3L1 mRNA19128835
C006632arsenic trioxidearsenic trioxide results in increased expression of CHI3L1 mRNA15761015
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in decreased expression of CHI3L1 mRNA15894607
C015001arsenitearsenite results in decreased expression of CHI3L1 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of CHI3L1 mRNA]18929588
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CHI3L1 protein"21135415
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of CHI3L1 mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to CHI3L1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CHI3L1 mRNA25908611
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CHI3L1 mRNA20713471
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of CHI3L1 mRNA20660070
D004958EstradiolEstradiol results in increased expression of CHI3L1 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of CHI3L1 mRNA27685785
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CHI3L1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased methylation of CHI3L1 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of CHI3L1 mRNA25181051
D002104CadmiumCadmium results in decreased expression of CHI3L1 mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of CHI3L1 promoter22457795
C018021cobaltous chloridecobaltous chloride results in decreased secretion of CHI3L1 protein22079246
C018021cobaltous chloridecobaltous chloride results in decreased expression of CHI3L1 mRNA24386269
D003471CuprizoneCuprizone results in increased expression of CHI3L1 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of CHI3L1 mRNA20106945|2798913
D000069439DasatinibDasatinib results in increased expression of CHI3L1 mRNA20579391
D003907DexamethasoneDexamethasone results in decreased expression of CHI3L1 mRNA16357325|2504701
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CHI3L1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of CHI3L1 mRNA28628672
D002945CisplatinCHI3L1 results in decreased susceptibility to Cisplatin20506295
D002945CisplatinCisplatin results in increased expression of CHI3L1 mRNA27594783
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in decreased expression of CHI3L1 mRNA21852083
D002117CalcitriolCalcitriol results in increased expression of CHI3L1 mRNA26485663
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of CHI3L1 mRNA"21785161
D004317DoxorubicinCHI3L1 results in decreased susceptibility to Doxorubicin20506295
D004317DoxorubicinDoxorubicin results in increased expression of CHI3L1 mRNA15205334
D005047EtoposideCHI3L1 results in decreased susceptibility to Etoposide20506295
D005472FluorouracilFluorouracil results in increased expression of CHI3L1 mRNA15205334
C039281furanfuran results in increased expression of CHI3L1 mRNA27387713
D005944GlucosamineGlucosamine analog results in decreased expression of CHI3L1 mRNA16142878
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CHI3L1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of CHI3L1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CHI3L1 mRNA25613284
D007501IronIron deficiency results in decreased expression of CHI3L1 mRNA20368581
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CHI3L1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of CHI3L1 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CHI3L1 mRNA26752646
D007649KetamineKetamine results in increased expression of CHI3L1 mRNA20080153
C017461lead nitrate[nickel chloride co-treated with lead nitrate] results in increased expression of CHI3L1 mRNA19187980
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CHI3L1 mRNA25613284
D008610Menthol[Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of CHI3L1 protein27818348
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CHI3L1 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CHI3L1 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CHI3L1 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of CHI3L1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CHI3L1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CHI3L1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CHI3L1 protein"21135415
C031721naphthalenenaphthalene results in increased expression of CHI3L1 mRNA18978301
C022838nickel chloride[nickel chloride co-treated with lead nitrate] results in increased expression of CHI3L1 mRNA19187980
C022838nickel chloridenickel chloride results in increased expression of CHI3L1 mRNA19187980
C022838nickel chloridenickel chloride affects the expression of CHI3L1 mRNA24670797
C028007nickel monoxidenickel monoxide results in increased expression of CHI3L1 mRNA19167457
D010047Ovalbumin[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of CHI3L1 mRNA19176365
D017239PaclitaxelPaclitaxel results in increased expression of CHI3L1 mRNA18754875
C016030pantogabpantogab results in increased expression of CHI3L1 mRNA17379144
D052638Particulate Matter[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of CHI3L1 mRNA19176365
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CHI3L1 mRNA26705709
C046012pentanalpentanal results in increased expression of CHI3L1 mRNA26079696
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of CHI3L1 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of CHI3L1 mRNA20813756
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of CHI3L1 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of CHI3L1 mRNA18497975
C059514resveratrol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in decreased expression of CHI3L1 protein]21029458
C059514resveratrolresveratrol results in decreased expression of CHI3L1 mRNA21029458
C059514resveratrolresveratrol results in decreased expression of CHI3L1 protein21029458
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in decreased expression of CHI3L1 mRNA21852083
D015474IsotretinoinIsotretinoin results in decreased expression of CHI3L1 mRNA20436886
D012822Silicon DioxideSilicon Dioxide results in increased expression of CHI3L1 mRNA23221170
D012822Silicon DioxideSilicon Dioxide results in increased expression of CHI3L1 mRNA22431001
D012834SilverSilver results in decreased expression of CHI3L1 mRNA27131904
D012999SomanSoman results in increased expression of CHI3L1 mRNA19281266
D053260SootSoot results in increased expression of CHI3L1 protein21135415
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CHI3L1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CHI3L1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CHI3L1 mRNA15667827|1993321
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CHI3L1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of CHI3L1 mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CHI3L1 mRNA27865774
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CHI3L1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CHI3L1 mRNA27404394
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CHI3L1 mRNA20133372
D014028Tobacco Smoke Pollution[Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of CHI3L1 protein27818348
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in decreased expression of CHI3L1 mRNA15894607
D014212TretinoinTretinoin results in increased expression of CHI3L1 mRNA16249480
C032910triadimefontriadimefon results in increased expression of CHI3L1 mRNA26705709
C011559tributyltintributyltin results in increased expression of CHI3L1 mRNA21683754
C012589trichostatin Atrichostatin A results in decreased expression of CHI3L1 mRNA24935251|2627250
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of CHI3L1 mRNA17982090
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CHI3L1 mRNA29024780
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHI3L1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CHI3L1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CHI3L1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of CHI3L1 mRNA23179753|2519280
D014635Valproic AcidValproic Acid results in increased methylation of CHI3L1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004568chitinase activity-IBA21873635  
GO:0004568chitinase activityNOTIDA8245017  9492324  
GO:0005201extracellular matrix structural constituent-NAS8245017  
GO:0008061chitin binding-IBA21873635  
GO:0008061chitin binding-IDA9492324  12775711  
GO:0030246carbohydrate binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-IEA-  
GO:0006032chitin catabolic process-IBA21873635  
GO:0006915apoptotic process-IEA-  
GO:0006954inflammatory response-IEP16234240  
GO:0007250activation of NF-kappaB-inducing kinase activity-ISS-  
GO:0009612response to mechanical stimulus-IEP20650887  
GO:0010800positive regulation of peptidyl-threonine phosphorylation-ISS-  
GO:0030324lung development-IMP18403759  
GO:0034612response to tumor necrosis factor-IEP16234240  
GO:0043312neutrophil degranulation-TAS-  
GO:0045766positive regulation of angiogenesis-IMP21385870  
GO:0051216cartilage development-NAS8245017  
GO:0051897positive regulation of protein kinase B signaling-IMP21385870  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IMP21385870  
GO:0070555response to interleukin-1-IEP16234240  
GO:0070741response to interleukin-6-IEP21478032  
GO:0071347cellular response to interleukin-1-IEA-  
GO:0071356cellular response to tumor necrosis factor-ISS-  
GO:0072606interleukin-8 secretion-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IBA21873635  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0005615extracellular space-IDA8245017  9492324  
GO:0005737cytoplasm-ISS-  
GO:0005783endoplasmic reticulum-ISS-  
GO:0031012extracellular matrix-NAS8245017  
GO:0035580specific granule lumen-TAS-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00520Amino sugar and nucleotide sugar metabolism
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25486056Circulating YKL-40 level, but not CHI3L1 gene variants, is associated with atherosclerosis-related quantitative traits and the risk of peripheral artery disease. (2014 Dec 4)Wu SInt J Mol Sci
19568425Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults. (2009 Jul 1)Rathcke CNPLoS One
29044854Targeted proteomic analysis of habitual coffee consumption. (2018 Feb)Cornelis MCJ Intern Med
24958781Plasma levels of the proinflammatory chitin-binding glycoprotein YKL-40, variation in the chitinase 3-like 1 gene (CHI3L1), and incident cardiovascular events. (2014 Jun 23)Ridker PMJ Am Heart Assoc
29783062YKL-40 levels increase with declining ankle-brachial index and are associated with long-term cardiovascular mortality in peripheral arterial disease patients. (2018 May 9)Hobaus CAtherosclerosis