Gene: NUDT3

11165
DIPP|DIPP-1|DIPP1
nudix hydrolase 3
protein-coding
6p21.31
Ensembl:ENSG00000272325 MIM:609228 Vega:OTTHUMG00000014545 UniprotKB:O95989
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PEA150.887
C1orf430.86
CREB30.859
YWHAE0.848
SNX30.846
SRSF90.844
VTI1B0.843
MRFAP10.837
CSDE10.836
RAB7A0.836

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.842
OR4F5-0.83
C20orf85-0.158
UPK1B-0.141
TEX33-0.138
OMD-0.135
SLC10A2-0.134
ENTHD1-0.126
ZBED2-0.126
ADH1A-0.124

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NUDT3 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of NUDT3 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of NUDT3 mRNA28959563
D001280AtrazineAtrazine results in decreased expression of NUDT3 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NUDT3 mRNA18061397|2010694
C044887beta-methylcholinebeta-methylcholine affects the expression of NUDT3 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of NUDT3 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NUDT3 mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of NUDT3 promoter22457795
C018021cobaltous chloridecobaltous chloride results in increased expression of NUDT3 mRNA19376846
D016572CyclosporineCyclosporine results in increased expression of NUDT3 mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NUDT3 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of NUDT3 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of NUDT3 mRNA25016146
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of NUDT3 mRNA23649840
D018120FinasterideFinasteride results in increased expression of NUDT3 mRNA24136188
D005485FlutamideFlutamide results in increased expression of NUDT3 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of NUDT3 mRNA23649840
C039281furanfuran results in increased methylation of NUDT3 gene22079235
C075954indolo(3,2-b)carbazole"indolo(3,2-b)carbazole results in decreased expression of NUDT3 mRNA"18061397
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NUDT3 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NUDT3 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NUDT3 mRNA28628672
D008727MethotrexateMethotrexate results in increased expression of NUDT3 mRNA24449571
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of NUDT3 mRNA27544571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NUDT3 mRNA23649840
C028007nickel monoxidenickel monoxide results in increased expression of NUDT3 mRNA19167457
C410127PCB 180PCB 180 results in increased expression of NUDT3 mRNA23829299
D010936Plant ExtractsPlant Extracts results in decreased expression of NUDT3 mRNA18061397
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of NUDT3 mRNA21427059
D012822Silicon DioxideSilicon Dioxide results in decreased expression of NUDT3 mRNA25351596
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NUDT3 mRNA18061397
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NUDT3 mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NUDT3 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NUDT3 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NUDT3 mRNA28065790
D014050TolueneToluene results in decreased expression of NUDT3 mRNA22967744
D014520UrethaneUrethane results in decreased expression of NUDT3 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of NUDT3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NUDT3 mRNA28001369
D014635Valproic AcidValproic Acid results in decreased expression of NUDT3 mRNA20546886|2142705
C025643vinclozolinvinclozolin results in decreased expression of NUDT3 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA19585659  
GO:0000298endopolyphosphatase activity-IBA21873635  
GO:0008486diphosphoinositol-polyphosphate diphosphatase activity-IBA21873635  
GO:0008486diphosphoinositol-polyphosphate diphosphatase activity-IDA10585413  
GO:0016818hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides-IBA21873635  
GO:0034431bis(5'-adenosyl)-hexaphosphatase activity-IBA21873635  
GO:0034432bis(5'-adenosyl)-pentaphosphatase activity-IBA21873635  
GO:0050072m7G(5')pppN diphosphatase activity-IBA21873635  
GO:0052840inositol diphosphate tetrakisphosphate diphosphatase activity-IEA-  
GO:0052841inositol bisdiphosphate tetrakisphosphate diphosphatase activity-TAS-  
GO:0052842inositol diphosphate pentakisphosphate diphosphatase activity-TAS-  
GO:0052843inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity-IEA-  
GO:0052844inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity-IEA-  
GO:0052845inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity-IEA-  
GO:0052846inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity-IEA-  
GO:0052847inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity-IEA-  
GO:0052848inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007267cell-cell signaling-TAS10419486  
GO:0015961diadenosine polyphosphate catabolic process-TAS10419486  
GO:0043647inositol phosphate metabolic process-TAS-  
GO:0071543diphosphoinositol polyphosphate metabolic process-IBA21873635  
GO:0071544diphosphoinositol polyphosphate catabolic process-IDA10585413  
GO:1901907diadenosine pentaphosphate catabolic process-IBA21873635  
GO:1901909diadenosine hexaphosphate catabolic process-IBA21873635  
GO:1901911adenosine 5'-(hexahydrogen pentaphosphate) catabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483249Inositol phosphate metabolismTAS
R-HSA-1855167Synthesis of pyrophosphates in the cytosolTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23978819Generalization of adiposity genetic loci to US Hispanic women. (2013 Aug 26)Graff MNutr Diabetes