Gene: FSTL1

11167
FRP|FSL1|MIR198|OCC-1|OCC1|tsc36
follistatin like 1
protein-coding
3q13.33
Ensembl:ENSG00000163430 MIM:605547 Vega:OTTHUMG00000159440 UniprotKB:Q12841
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.799e-1 (AD)  6.236e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MSN0.87
CMTM60.869
ITGA60.857
STAT30.854
ANO60.854
MYD880.849
OSMR0.847
TNFRSF1A0.847
TEAD30.843
BNIP20.842

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.529
ABCC12-0.492
DRD5-0.492
CALHM1-0.476
DLK2-0.475
PPEF1-0.468
HAS1-0.467
SMIM18-0.464
MYADML2-0.462
MARCH4-0.458

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of FSTL1 mRNA"24172598
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of FSTL1 mRNA"25380136
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of FSTL1 mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FSTL1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FSTL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FSTL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FSTL1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FSTL1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of FSTL1 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of FSTL1 mRNA17585979
D020106AcrylamideAcrylamide results in decreased expression of FSTL1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FSTL1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FSTL1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FSTL1 mRNA22484513
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FSTL1 mRNA16483693
D001280AtrazineAtrazine results in increased expression of FSTL1 mRNA25929836
D001280AtrazineAtrazine results in increased expression of FSTL1 mRNA22378314
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FSTL1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FSTL1 mRNA28651000
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FSTL1 mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of FSTL1 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FSTL1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of FSTL1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of FSTL1 protein28285737
C006780bisphenol ASodium Selenite inhibits the reaction [bisphenol A results in increased expression of FSTL1 protein]28285737
D002065BuspironeBuspirone results in decreased expression of FSTL1 mRNA24136188
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of FSTL1 mRNA19840844
D002211CapsaicinCapsaicin results in increased expression of FSTL1 protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein]22150557
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FSTL1 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FSTL1 mRNA16239168
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FSTL1 mRNA20938992
D002994ClofibrateClofibrate results in decreased expression of FSTL1 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased secretion of FSTL1 protein22079246
D003300Copper[Disulfiram binds to Copper] which results in increased expression of FSTL1 mRNA24690739
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of FSTL1 mRNA15467011
D003471CuprizoneCuprizone affects the expression of FSTL1 mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FSTL1 mRNA]18200517
D016572CyclosporineCyclosporine results in decreased expression of FSTL1 mRNA20106945|2798913
C014347decitabinedecitabine results in increased expression of FSTL1 mRNA19194470
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FSTL1 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of FSTL1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of FSTL1 mRNA21151649
D002945CisplatinFSTL1 protein inhibits the reaction [Cisplatin results in increased expression of IL1B protein]20861081
D004041Dietary FatsDietary Fats results in increased expression of FSTL1 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of FSTL1 mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of FSTL1 mRNA]21852083
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FSTL1 mRNA18164116
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of FSTL1 mRNA25380136
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of FSTL1 mRNA24690739
D004237DiuronDiuron metabolite results in decreased expression of FSTL1 mRNA24172598
D004237DiuronDiuron results in decreased expression of FSTL1 mRNA25152437
D004237DiuronDiuron results in increased expression of FSTL1 mRNA21551480
C070609EMD 53998EMD 53998 analog results in decreased expression of FSTL1 mRNA24977338
C118739entinostatentinostat results in decreased expression of FSTL1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FSTL1 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FSTL1 mRNA16079270
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FSTL1 mRNA20938992
D004397FonofosFonofos results in increased methylation of FSTL1 promoter22847954
C039281furanfuran results in decreased methylation of FSTL1 gene27387713
C039281furanfuran results in increased expression of FSTL1 mRNA27387713
D019833GenisteinGenistein results in decreased expression of FSTL1 mRNA21810550
D006118GriseofulvinGriseofulvin affects the expression of FSTL1 mRNA12735108
C010176halofuginonehalofuginone results in increased expression of FSTL1 mRNA17180598
D017313FenretinideFenretinide results in decreased expression of FSTL1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FSTL1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FSTL1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of FSTL1 mRNA27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FSTL1 mRNA20938992
D008727MethotrexateFSTL1 protein affects the susceptibility to Methotrexate16217747
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of FSTL1 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FSTL1 mRNA28001369
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of FSTL1 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of FSTL1 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FSTL1 mRNA19840844
D015735MifepristoneMifepristone results in increased expression of FSTL1 mRNA19439560
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FSTL1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of FSTL1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FSTL1 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of FSTL1 mRNA25380136
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein]22150557
C017096n-butoxyethanoln-butoxyethanol results in increased expression of FSTL1 mRNA19812364
C051752nefazodonenefazodone results in decreased expression of FSTL1 mRNA24136188
C012655nimesulidenimesulide results in decreased expression of FSTL1 mRNA24136188
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of FSTL1 mRNA19840844
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of FSTL1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of FSTL1 mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of FSTL1 mRNA18042831
D010269ParaquatParaquat results in increased expression of FSTL1 mRNA26758514
D010269ParaquatParaquat results in increased expression of FSTL1 protein26758514
D010269Paraquat"plant extract, Puerariae Radix inhibits the reaction [Paraquat results in increased expression of FSTL1 mRNA]"26758514
D010269Paraquat"plant extract, Puerariae Radix inhibits the reaction [Paraquat results in increased expression of FSTL1 protein]"26758514
D010278ParathionParathion results in increased methylation of FSTL1 promoter22847954
D052638Particulate Matter[FSTL1 gene mutant form affects the susceptibility to Particulate Matter] which results in decreased expression of FSTL1 mRNA21222557|2122255
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of FSTL1 mRNA25868421
D010634PhenobarbitalPhenobarbital affects the expression of FSTL1 mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FSTL1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FSTL1 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FSTL1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of FSTL1 mRNA19162173
C442842plant extract, Puerariae Radix"plant extract, Puerariae Radix inhibits the reaction [Paraquat results in increased expression of FSTL1 mRNA]"26758514
C442842plant extract, Puerariae Radix"plant extract, Puerariae Radix inhibits the reaction [Paraquat results in increased expression of FSTL1 protein]"26758514
C513428pyrachlostrobinpyrachlostrobin results in increased expression of FSTL1 mRNA27029645
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of FSTL1 mRNA]21852083
C089730rosiglitazonerosiglitazone results in increased expression of FSTL1 mRNA25572481
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of FSTL1 mRNA21427059
C078903seocalcitolseocalcitol results in increased expression of FSTL1 mRNA12040012
C017947sodium arsenitesodium arsenite results in decreased expression of FSTL1 mRNA18812580
D018038Sodium SeleniteSodium Selenite inhibits the reaction [bisphenol A results in increased expression of FSTL1 protein]28285737
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein]22150557
C012568terbufosterbufos results in increased methylation of FSTL1 promoter22847954
D013755Tetradecanoylphorbol Acetate[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FSTL1 mRNA19840844
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FSTL1 mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of FSTL1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of FSTL1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of FSTL1 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of FSTL1 mRNA24935251
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FSTL1 mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of FSTL1 mRNA18200517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FSTL1 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of FSTL1 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of FSTL1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FSTL1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of FSTL1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid analog results in decreased expression of FSTL1 mRNA21427059
D014635Valproic AcidValproic Acid results in decreased expression of FSTL1 mRNA21427059
D014640VancomycinVancomycin results in decreased expression of FSTL1 mRNA18930951
D001335Vehicle Emissions[FSTL1 gene mutant form affects the susceptibility to Vehicle Emissions] which results in decreased expression of FSTL1 mRNA21222557|2122255
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FSTL1 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of FSTL1 mRNA19165385
D002762CholecalciferolCholecalciferol results in increased expression of FSTL1 mRNA17170073
C088658zoledronic acidzoledronic acid results in increased expression of FSTL1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI19060904  20860622  22265692  25416956  
GO:0008201heparin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0030509BMP signaling pathway-TAS-  
GO:0042594response to starvation-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-201451Signaling by BMPTAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957275Post-translational protein phosphorylationTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28852126Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma. (2017 Aug 29)Chiou JSci Rep