Gene: STRAP

11171
MAWD|PT-WD|UNRIP
serine/threonine kinase receptor associated protein
protein-coding
12p12.3
Ensembl:ENSG00000023734 MIM:605986 Vega:OTTHUMG00000168791 UniprotKB:Q9Y3F4
NC_000012.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.030e-1 (AD)  4.470e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBE2D20.968
PSMD140.96
RAN0.954
VDAC20.953
RAB1A0.952
MORF4L20.952
MATR30.951
SKP10.951
CCT6A0.951
EIF1B0.95

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.805
OR4F29-0.801
MTRNR2L10-0.221
MTRNR2L6-0.219
KLRB1-0.219
MTRNR2L9-0.21
VNN3-0.206
MTRNR2L3-0.204
CXCR2-0.202
C8orf74-0.196

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of STRAP mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of STRAP protein22230336
D000082AcetaminophenAcetaminophen affects the expression of STRAP mRNA17562736
C006632arsenic trioxidearsenic trioxide results in increased expression of STRAP mRNA21461292
D001554BenzeneBenzene results in increased expression of STRAP mRNA15120971|1512265
C006780bisphenol Abisphenol A affects the expression of STRAP mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of STRAP mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of STRAP mRNA25181051
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of STRAP mRNA23650126
C100187chloropicrinchloropicrin results in increased expression of STRAP mRNA26352163
D002738ChloroquineChloroquine results in decreased expression of STRAP mRNA19393257
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of STRAP mRNA28472532
D003300CopperCopper results in decreased expression of STRAP protein23882024
C030973cupric oxidecupric oxide analog results in decreased expression of STRAP protein23882024
D016572CyclosporineCyclosporine results in increased expression of STRAP mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of STRAP mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of STRAP mRNA21266533
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of STRAP protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of STRAP mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of STRAP mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STRAP mRNA17942748
D005485FlutamideFlutamide results in increased expression of STRAP mRNA24136188
C029424hydrazinehydrazine results in increased expression of STRAP mRNA15282401
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of STRAP mRNA25613284
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of STRAP mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of STRAP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of STRAP mRNA"25554681
C051752nefazodonenefazodone results in increased expression of STRAP mRNA24136188
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of STRAP protein22609092
D010634PhenobarbitalPhenobarbital affects the expression of STRAP mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of STRAP mRNA23811191
C045950propiconazolepropiconazole results in increased expression of STRAP mRNA21278054
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of STRAP mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of STRAP mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STRAP mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STRAP mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of STRAP mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of STRAP mRNA25613284
C012589trichostatin Atrichostatin A results in increased expression of STRAP mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of STRAP mRNA19042947
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of STRAP gene25560391
C025643vinclozolinvinclozolin results in decreased expression of STRAP mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of STRAP mRNA23869203
D024483Vitamin K 3Vitamin K 3 affects the expression of STRAP mRNA20044591
C111237vorinostatvorinostat results in decreased expression of STRAP protein20543569

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005102signaling receptor binding-IEA-  
GO:0005515protein binding-IPI15848170  17314099  17929853  26496610  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0000387spliceosomal snRNP assembly-IDA18984161  
GO:0010633negative regulation of epithelial cell migration-IMP23687415  
GO:0010719negative regulation of epithelial to mesenchymal transition-IMP23687415  
GO:0030277maintenance of gastrointestinal epithelium-IMP17929853  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-IMP23687415  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-TAS-  
GO:0050680negative regulation of epithelial cell proliferation-IMP23687415  
GO:0060394negative regulation of pathway-restricted SMAD protein phosphorylation-IMP23687415  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA17929853  
GO:0005829cytosol-IDA18984161  20513430  
GO:0005829cytosol-TAS-  
GO:0032797SMN complex-IDA18984161  
GO:0034719SMN-Sm protein complex-IDA18984161  
KEGG ID KEGG Term
hsa03013RNA transport
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexIEA
R-HSA-2173788Downregulation of TGF-beta receptor signalingTAS
R-HSA-2173788Downregulation of TGF-beta receptor signalingIEA
R-HSA-2173789TGF-beta receptor signaling activates SMADsTAS
R-HSA-2173789TGF-beta receptor signaling activates SMADsIEA
R-HSA-9006936Signaling by TGF-beta family membersTAS
R-HSA-9006936Signaling by TGF-beta family membersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22521759Muscle sarcomas and alopecia in A/J mice chronically treated with nicotine. (2012 Nov 27)Galitovskiy VLife Sci
28723003Breast, Reduction (2018 Jan)Sachs D-