Gene: ADAMTS7

11173
ADAM-TS 7|ADAM-TS7|ADAMTS-7
ADAM metallopeptidase with thrombospondin type 1 motif 7
protein-coding
15q25.1
Ensembl:ENSG00000136378 MIM:605009 Vega:OTTHUMG00000172907 UniprotKB:Q9UKP4
NG_011492.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.499e-1 (AD)  1.000e-12 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC43A30.753
BEST30.724
GALNT100.722
CMTM30.712
MATN20.705
GDNF0.694
LIMD10.692
RRBP10.68
LDLRAD30.678
SH2D2A0.677

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HCN1-0.471
PTPRR-0.465
ST6GALNAC5-0.464
CDH8-0.462
KCNB2-0.459
GRIN2A-0.452
ANO3-0.448
ROBO2-0.444
KCNA2-0.442
CLVS2-0.441

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADAMTS7 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADAMTS7 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADAMTS7 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADAMTS7 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ADAMTS7 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADAMTS7 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ADAMTS7 mRNA"21346803
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ADAMTS7 mRNA16788091
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of ADAMTS7 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of ADAMTS7 mRNA17562736
C006780bisphenol Abisphenol A affects the expression of ADAMTS7 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ADAMTS7 mRNA20938992
D002994ClofibrateClofibrate results in decreased expression of ADAMTS7 mRNA23811191
D003471CuprizoneCuprizone results in increased expression of ADAMTS7 mRNA26577399
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of ADAMTS7 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ADAMTS7 mRNA27392435
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in decreased expression of ADAMTS7 mRNA20705681
D002945CisplatinCisplatin results in increased expression of ADAMTS7 mRNA27392435
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ADAMTS7 mRNA17351261
D005485FlutamideFlutamide results in decreased expression of ADAMTS7 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ADAMTS7 mRNA20938992
D019833GenisteinGenistein results in increased expression of ADAMTS7 mRNA18847459
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ADAMTS7 mRNA27392435
C045463leflunomideleflunomide results in decreased expression of ADAMTS7 mRNA24136188
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ADAMTS7 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of ADAMTS7 mRNA17400583
C002950methylformamidemethylformamide affects the expression of ADAMTS7 mRNA17040096
C002950methylformamidemethylformamide analog affects the expression of ADAMTS7 mRNA17040096
C523799MRK 003ADAMTS7 results in increased susceptibility to MRK 00319903844
C051752nefazodonenefazodone results in decreased expression of ADAMTS7 mRNA24136188
C012655nimesulidenimesulide results in decreased expression of ADAMTS7 mRNA24136188
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in decreased expression of ADAMTS7 mRNA20705681
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADAMTS7 mRNA"25510870
C006253pirinixic acidpirinixic acid results in decreased expression of ADAMTS7 mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of ADAMTS7 mRNA23557933
D011372ProgestinsProgestins results in increased expression of ADAMTS7 mRNA19609016
D011441PropylthiouracilPropylthiouracil results in increased expression of ADAMTS7 mRNA24780913
D013629TamoxifenTamoxifen results in increased expression of ADAMTS7 mRNA25123088
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of ADAMTS7 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADAMTS7 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ADAMTS7 promoter]19654925|2188995
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADAMTS7 mRNA21215274
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ADAMTS7 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-IDA18485748  
GO:0005515protein binding-IPI18485748  
GO:0008237metallopeptidase activity-TAS10464288  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0032331negative regulation of chondrocyte differentiation-IDA22247065  
GO:0051603proteolysis involved in cellular protein catabolic process-IMP18485748  
GO:0071347cellular response to interleukin-1-IMP18485748  
GO:0071356cellular response to tumor necrosis factor-IMP18485748  
GO:0071773cellular response to BMP stimulus-IDA22247065  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0009986cell surface-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5173214O-glycosylation of TSR domain-containing proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29311356Letter by Jin-shan and Xue-bin Regarding Article, "Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions". (2018 Jan 9)Jin-Shan HCirculation
28461624Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions. (2017 Jun 13)Saleheen DCirculation