Gene: BAZ1A

11177
ACF1|WALp1|WCRF180|hACF1
bromodomain adjacent to zinc finger domain 1A
protein-coding
14q13.1-q13.2
Ensembl:ENSG00000198604 MIM:605680 Vega:OTTHUMG00000140216 UniprotKB:Q9NRL2
NC_000014.9
PubMed
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.067e-1 (AD)  4.762e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLIC40.876
IFI160.873
ELF10.872
TANC10.869
SPATA130.867
WWTR10.862
REST0.859
CBFB0.857
SFT2D20.856
PARP40.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.632
MARCH4-0.629
ABCC12-0.628
CDH22-0.609
F7-0.607
NEUROD6-0.604
ADRA1D-0.598
KCNQ4-0.592
KCNB2-0.588
FBLN7-0.588

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of BAZ1A mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of BAZ1A mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of BAZ1A mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of BAZ1A mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of BAZ1A mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of BAZ1A mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of BAZ1A mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAZ1A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAZ1A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAZ1A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAZ1A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAZ1A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAZ1A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAZ1A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAZ1A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAZ1A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAZ1A mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of BAZ1A mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of BAZ1A protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of BAZ1A mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of BAZ1A mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of BAZ1A mRNA24449571
D001280AtrazineAtrazine results in increased expression of BAZ1A mRNA25929836
D001280AtrazineAtrazine results in decreased expression of BAZ1A mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BAZ1A mRNA22316170|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BAZ1A mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BAZ1A mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of BAZ1A mRNA"26238291
D004958EstradiolEstradiol results in increased expression of BAZ1A mRNA23019147
C044887beta-methylcholinebeta-methylcholine affects the expression of BAZ1A mRNA21179406
C006780bisphenol Abisphenol A affects the expression of BAZ1A mRNA23557687
C006780bisphenol Abisphenol A results in decreased expression of BAZ1A mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of BAZ1A mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of BAZ1A mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of BAZ1A gene28505145
D002220CarbamazepineCarbamazepine affects the expression of BAZ1A mRNA25979313
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of BAZ1A mRNA24763279
D019327Copper SulfateCopper Sulfate results in increased expression of BAZ1A mRNA19549813
D003471CuprizoneCuprizone results in increased expression of BAZ1A mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of BAZ1A mRNA25562108
C004742daidzein[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of BAZ1A mRNA16963248
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of BAZ1A mRNA17361019
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of BAZ1A mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of BAZ1A mRNA18042831
D004237DiuronDiuron results in increased expression of BAZ1A mRNA21551480
D004726EndosulfanEndosulfan results in increased expression of BAZ1A protein26615145
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BAZ1A mRNA22079256
D019833Genistein[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of BAZ1A mRNA16963248
D005839GentamicinsGentamicins results in increased expression of BAZ1A mRNA22061828
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of BAZ1A mRNA22634610
C086566glycitein[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of BAZ1A mRNA16963248
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of BAZ1A mRNA24763279
D017313FenretinideFenretinide results in increased expression of BAZ1A mRNA28973697
D007213IndomethacinIndomethacin results in decreased expression of BAZ1A mRNA16984733
C544151jinfukangjinfukang results in decreased expression of BAZ1A mRNA27392435
D007854LeadLead affects the expression of BAZ1A mRNA28903495
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of BAZ1A mRNA26378955
D008627Mercuric ChlorideMercuric Chloride affects the expression of BAZ1A mRNA20353558
D008727MethotrexateMethotrexate results in decreased expression of BAZ1A mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of BAZ1A mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of BAZ1A mRNA"20188158
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of BAZ1A mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of BAZ1A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of BAZ1A mRNA"25554681|2562005
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of BAZ1A mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of BAZ1A mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAZ1A mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of BAZ1A mRNA26272509
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of BAZ1A mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the expression of BAZ1A mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAZ1A mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of BAZ1A mRNA26272509
C014153pirimiphos methylpirimiphos methyl results in increased expression of BAZ1A mRNA27845199
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BAZ1A mRNA19710929
D010894PiroxicamPiroxicam results in decreased expression of BAZ1A mRNA21858171
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BAZ1A mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of BAZ1A mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of BAZ1A mRNA22238285
D011441PropylthiouracilPropylthiouracil results in increased expression of BAZ1A mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of BAZ1A mRNA27029645
D011794QuercetinQuercetin results in increased expression of BAZ1A mRNA21632981
D012834SilverSilver results in decreased expression of BAZ1A mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of BAZ1A mRNA21795629
D012969Sodium FluorideSodium Fluoride results in increased expression of BAZ1A protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of BAZ1A mRNA18175754
D012999SomanSoman results in increased expression of BAZ1A mRNA19281266
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of BAZ1A mRNA26378955
D013629TamoxifenTamoxifen affects the expression of BAZ1A mRNA14699072
C004648testosterone enanthatetestosterone enanthate affects the expression of BAZ1A mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BAZ1A mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BAZ1A mRNA18465118
D019284ThapsigarginThapsigargin results in increased expression of BAZ1A protein24648495
D013853ThioacetamideThioacetamide results in increased expression of BAZ1A mRNA23411599
D014050TolueneToluene results in increased expression of BAZ1A mRNA28245982
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of BAZ1A mRNA25729387
D019772TopotecanTopotecan results in decreased expression of BAZ1A mRNA25729387
D014212TretinoinTretinoin results in decreased expression of BAZ1A mRNA23724009
D014212TretinoinTretinoin results in increased expression of BAZ1A mRNA20488242
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAZ1A mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of BAZ1A mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of BAZ1A mRNA19042947
C406224valdecoxibvaldecoxib results in increased expression of BAZ1A mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAZ1A mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of BAZ1A mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of BAZ1A gene29154799
D014810Vitamin EVitamin E results in decreased expression of BAZ1A mRNA19244175
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BAZ1A mRNA"27188386
C111237vorinostatvorinostat results in increased expression of BAZ1A mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004402histone acetyltransferase activityNOTTAS10662543  
GO:0005515protein binding-IPI10655480  11980720  17500595  17519354  26816381  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006261DNA-dependent DNA replication-IDA12434153  
GO:0006338chromatin remodeling-TAS10662543  27328812  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-NAS10662543  
GO ID GO Term Qualifier Evidence PubMed
GO:0008623CHRAC-IDA10880450  
GO:0016590ACF complex-TAS10662543  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28412501Regulation of BAZ1A and nucleosome positioning in the nucleus accumbens in response to cocaine. (2017 Jun 14)Sun HNeuroscience