Gene: CHIT1

1118
CHI3|CHIT|CHITD
chitinase 1
protein-coding
1q32.1
Ensembl:ENSG00000133063 MIM:600031 Vega:OTTHUMG00000042126 UniprotKB:Q13231
NG_012867.1
PubMed
0   ANCO-SNPs
ND
1   
2.097e-3 (AD)  5.761e-1 (ND)   (Frontal_Cortex)
2.262e-1 (AD)  1.969e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RASL11B0.558
SERPINF10.552
KIAA1211L0.545
PREP0.544
NRN10.533
SMAP20.53
EPHX40.529
LRFN50.529
FAR20.527
TMOD10.527

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.401
MORC4-0.344
ZNF501-0.343
CARHSP1-0.329
SFRP4-0.329
ACOX2-0.325
FOXJ1-0.321
ZFHX4-0.32
PARD3B-0.319
SYDE1-0.315

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02325Isopropyl AlcoholSmall Molecule67-63-0Approved|InvestigationalTarget
DB03109N-Acetyl-D-AllosamineSmall MoleculeExperimentalTarget
DB035392-(Acetylamino)-2-Deoxy-6-O-Methyl-Alpha-D-AllopyranoseSmall MoleculeExperimentalTarget
DB03632ArgifinSmall MoleculeExperimentalTarget
DB04350ArgadinSmall Molecule289665-92-5ExperimentalTarget
DB04404AllosamizolineSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHIT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHIT1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CHIT1 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of CHIT1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of CHIT1 mRNA28959563
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of CHIT1 mRNA"19936710
C054851allosamidinallosamidin results in decreased activity of CHIT1 protein16005164
C006632arsenic trioxidearsenic trioxide results in decreased expression of CHIT1 mRNA19128835
D001280AtrazineAtrazine results in increased expression of CHIT1 mRNA22378314
D001374AzacitidineAzacitidine results in increased expression of CHIT1 mRNA20823114
D004958EstradiolEstradiol results in increased expression of CHIT1 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of CHIT1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CHIT1 mRNA18154678
D002686ChitinCHIT1 protein binds to Chitin16005164
D004390ChlorpyrifosChlorpyrifos affects the expression of CHIT1 mRNA21496282
D004390Chlorpyrifos[nickel chloride co-treated with Chlorpyrifos] affects the expression of CHIT1 mRNA21496282
D003300CopperCopper results in increased expression of CHIT1 mRNA18522721
D003300CopperCopper affects the expression of CHIT1 mRNA23825565
C039281furanfuran results in increased methylation of CHIT1 gene22079235
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of CHIT1 mRNA19376150
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CHIT1 mRNA25613284
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CHIT1 mRNA21641980
D009532NickelNickel results in decreased expression of CHIT1 mRNA24084258
C022838nickel chloridenickel chloride affects the expression of CHIT1 mRNA21496282
C022838nickel chloride[nickel chloride co-treated with Chlorpyrifos] affects the expression of CHIT1 mRNA21496282
C030110oxaliplatinoxaliplatin results in increased expression of CHIT1 mRNA25729387
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CHIT1 mRNA19710929
C005556propionaldehydepropionaldehyde results in decreased expression of CHIT1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of CHIT1 mRNA24780913
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CHIT1 mRNA21641980
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CHIT1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of CHIT1 mRNA23557971
D019772TopotecanTopotecan results in decreased expression of CHIT1 mRNA25729387
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CHIT1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of CHIT1 mRNA23179753|2627250

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds-TAS-  
GO:0004568chitinase activity-IBA21873635  
GO:0004568chitinase activity-TAS9748235  
GO:0008061chitin binding-IBA21873635  
GO:0008061chitin binding-TAS9748235  
GO:0008843endochitinase activity-IDA19725875  
GO ID GO Term Qualifier Evidence PubMed
GO:0000272polysaccharide catabolic process-IEA-  
GO:0006032chitin catabolic process-IBA21873635  
GO:0006032chitin catabolic process-IDA19725875  
GO:0006032chitin catabolic process-TAS9748235  
GO:0006955immune response-NAS9748235  
GO:0009617response to bacterium-TAS9402970  
GO:0043312neutrophil degranulation-TAS-  
GO:0044245polysaccharide digestion-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IBA21873635  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA19725875  
GO:0005764lysosome-IEA-  
GO:0035580specific granule lumen-TAS-  
GO:1904724tertiary granule lumen-TAS-  
KEGG ID KEGG Term
hsa00520Amino sugar and nucleotide sugar metabolism
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-189085Digestion of dietary carbohydrateTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-8935690DigestionTAS
R-HSA-8963743Digestion and absorptionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18845328Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit. (2008 Nov)Seibold MAJ Allergy Clin Immunol