Gene: MAP4K5

11183
GCKR|KHS|KHS1|MAPKKKK5
mitogen-activated protein kinase kinase kinase kinase 5
protein-coding
14q22.1
Ensembl:ENSG00000012983 MIM:604923 Vega:OTTHUMG00000170888 UniprotKB:Q9Y4K4
NC_000014.9
PubMed
0   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.494e-1 (AD)  2.812e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAXBP10.892
ANKRD13A0.892
ELF20.891
CEP440.891
OSBPL90.89
MBTD10.887
TIA10.879
LRCH30.878
ZNF4510.877
PAN30.875

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.575
OR4F29-0.55
HES5-0.199
OR4F16-0.188
GOLGA6L1-0.18
HMHB1-0.172
STON1-GTF2A1L-0.168
CRH-0.167
PPIAL4D-0.159
KRTAP19-1-0.155

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of MAP4K5 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MAP4K5 mRNA"27291303
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAP4K5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAP4K5 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of MAP4K5 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of MAP4K5 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MAP4K5 gene27153756
D001104ArbutinArbutin results in decreased expression of MAP4K5 mRNA17103032
D001151ArsenicArsenic affects the methylation of MAP4K5 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of MAP4K5 mRNA"17331233
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MAP4K5 mRNA"20018196
C006780bisphenol Abisphenol A affects the expression of MAP4K5 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MAP4K5 mRNA26364221
C006780bisphenol Abisphenol A affects the expression of MAP4K5 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of MAP4K5 mRNA25181051
D002104CadmiumCadmium results in increased expression of MAP4K5 mRNA23369406
D060729Coal AshCoal Ash results in decreased expression of MAP4K5 mRNA19000753
D016572CyclosporineCyclosporine results in increased expression of MAP4K5 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of MAP4K5 mRNA19770486
D004147DioxinsDioxins affects the expression of MAP4K5 mRNA20463971
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of MAP4K5 mRNA]15016801
C001277geldanamycingeldanamycin results in increased expression of MAP4K5 mRNA26705709
D017313FenretinideFenretinide results in increased expression of MAP4K5 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MAP4K5 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of MAP4K5 mRNA27392435
C008261lead acetatelead acetate results in increased expression of MAP4K5 mRNA21322097
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MAP4K5 mRNA23103053
C017096n-butoxyethanoln-butoxyethanol results in increased expression of MAP4K5 mRNA19812364
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MAP4K5 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of MAP4K5 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of MAP4K5 mRNA]22629407
D010634PhenobarbitalPhenobarbital affects the expression of MAP4K5 mRNA19159669
D010936Plant ExtractsPlant Extracts results in increased expression of MAP4K5 mRNA23557933
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of MAP4K5 mRNA21427059
D012643Selenium[Selenium deficiency co-treated with Vitamin E deficiency] results in increased expression of MAP4K5 mRNA11444866
D018038Sodium SeleniteSodium Selenite results in decreased expression of MAP4K5 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MAP4K5 mRNA17555868
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MAP4K5 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MAP4K5 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MAP4K5 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of MAP4K5 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of MAP4K5 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MAP4K5 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of MAP4K5 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of MAP4K5 mRNA21934132
D014212TretinoinTretinoin results in increased expression of MAP4K5 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAP4K5 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of MAP4K5 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of MAP4K5 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of MAP4K5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MAP4K5 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased expression of MAP4K5 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MAP4K5 gene25560391
D014810Vitamin E[Selenium deficiency co-treated with Vitamin E deficiency] results in increased expression of MAP4K5 mRNA11444866
C111237vorinostatvorinostat results in decreased expression of MAP4K5 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-TAS9038372  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA9038372  
GO:0005515protein binding-IPI9788432  17474147  19380743  20936779  21706016  
GO:0005524ATP binding-IDA9038372  
GO:0008349MAP kinase kinase kinase kinase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IBA21873635  
GO:0000185activation of MAPKKK activity-IEA-  
GO:0006468protein phosphorylation-IDA9038372  
GO:0007257activation of JUN kinase activity-TAS9038372  
GO:0007346regulation of mitotic cell cycle-IBA21873635  
GO:0023014signal transduction by protein phosphorylation-IBA21873635  
GO:0032147activation of protein kinase activity-IBA21873635  
GO:0035556intracellular signal transduction-IDA9038372  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA9038372  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal