Gene: RASSF1

11186
123F2|NORE2A|RASSF1A|RDA32|REH3P21
Ras association domain family member 1
protein-coding
3p21.31
Ensembl:ENSG00000068028 MIM:605082 Vega:OTTHUMG00000149958 UniprotKB:Q9NS23
NG_023270.1
PubMed
0   ANCO-SNPs
ND
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.471e-1 (AD)  6.233e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UIMC10.813
RELA0.8
NFKBIA0.798
LMNA0.792
CCNL10.79
RRBP10.787
DNM20.783
PFN10.777
SAT10.773
TPM40.773

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.525
OR4F5-0.516
KIT-0.211
HAPLN1-0.207
BTBD18-0.202
PCDHAC1-0.192
GPR52-0.191
NXPH2-0.191
IGF1-0.191
CYP1A1-0.184

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of RASSF1 mRNA28329830
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of RASSF1 mRNA"20713471
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RASSF1 mRNA"21346803
C501332ABT-737ABT-737 promotes the reaction [RASSF1 results in increased susceptibility to Cisplatin]21880625
C501332ABT-737ABT-737 promotes the reaction [RASSF1 results in increased susceptibility to Etoposide]21880625
D000082AcetaminophenAcetaminophen results in increased expression of RASSF1 mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of RASSF1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RASSF1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of RASSF1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RASSF1 mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased methylation of RASSF1 promoter"26410583
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RASSF1 mRNA24449571
D001151ArsenicArsenic affects the methylation of RASSF1 gene25304211
D001151ArsenicArsenic results in increased methylation of RASSF1 promoter15987713
C006632arsenic trioxidearsenic trioxide promotes the reaction [decitabine results in increased expression of RASSF1 mRNA]16613325
C006632arsenic trioxidearsenic trioxide results in decreased methylation of RASSF1 gene20079060
C006632arsenic trioxidearsenic trioxide results in decreased methylation of RASSF1 promoter16613325
C006632arsenic trioxide[arsenic trioxide results in decreased methylation of RASSF1 promoter] which results in increased expression of RASSF1 mRNA16613325|1661332
C006632arsenic trioxidearsenic trioxide results in increased expression of and affects the localization of RASSF1 protein16613325
C006632arsenic trioxidearsenic trioxide results in increased expression of RASSF1 mRNA16613325|2007906
C006632arsenic trioxidearsenic trioxide results in increased expression of RASSF1 protein20079060
C006632arsenic trioxidedecitabine promotes the reaction [arsenic trioxide results in increased expression of RASSF1 mRNA]16613325
D001194AsbestosAsbestos results in increased methylation of RASSF1 promoter15911247
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of RASSF1 mRNA"17331233
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of RASSF1 mRNA"18687144
D001280AtrazineAtrazine results in increased expression of RASSF1 mRNA22378314
D001280AtrazineAtrazine results in decreased expression of RASSF1 mRNA22982499
C547126AZM551248AZM551248 results in increased expression of RASSF1 mRNA22323515
D053119BenzophenanthridinesBenzophenanthridines analog results in decreased expression of RASSF1 mRNA23117580
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RASSF1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RASSF1 mRNA22228805
D004958EstradiolEstradiol affects the expression of RASSF1 mRNA15598610
D004958EstradiolEstradiol results in decreased expression of RASSF1 mRNA20008439
D004958EstradiolEstradiol results in increased methylation of RASSF1 exon20008439
D004958EstradiolEstradiol results in increased methylation of RASSF1 promoter20008439
C044887beta-methylcholinebeta-methylcholine affects the expression of RASSF1 mRNA21179406
C095105bexarotenebexarotene results in decreased expression of RASSF1 mRNA17849452
C006780bisphenol Abisphenol A affects the expression of RASSF1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of RASSF1 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RASSF1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of RASSF1 mRNA25181051
D002087ButyratesButyrates promotes the reaction [decitabine results in decreased methylation of RASSF1 promoter]18203293
D002087ButyratesButyrates promotes the reaction [decitabine results in increased expression of RASSF1 mRNA]18203293
D002087ButyratesButyrates promotes the reaction [decitabine results in increased expression of RASSF1 protein]18203293
D002104CadmiumCadmium results in increased methylation of RASSF1 promoter17938735
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of RASSF1 protein17938735
D019256Cadmium Chloridedecitabine inhibits the reaction [Cadmium Chloride results in decreased expression of RASSF1 protein]17938735
D019256Cadmium Chloridedecitabine inhibits the reaction [Cadmium Chloride results in increased methylation of RASSF1 promoter]17938735
C031180chrysenechrysene results in increased expression of RASSF1 mRNA26377693
D003078ColchicineColchicine results in increased expression of RASSF1 mRNA20624997
D016572CyclosporineCyclosporine results in increased expression of RASSF1 mRNA20106945|2556210
C014347decitabinearsenic trioxide promotes the reaction [decitabine results in increased expression of RASSF1 mRNA]16613325
C014347decitabineButyrates promotes the reaction [decitabine results in decreased methylation of RASSF1 promoter]18203293
C014347decitabineButyrates promotes the reaction [decitabine results in increased expression of RASSF1 mRNA]18203293
C014347decitabineButyrates promotes the reaction [decitabine results in increased expression of RASSF1 protein]18203293
C014347decitabinedecitabine affects the expression of RASSF1 mRNA18320071
C014347decitabinedecitabine affects the methylation of RASSF1 promoter17526942|1757124
C014347decitabine[decitabine co-treated with trichostatin A] affects the expression of RASSF1 protein17019711
C014347decitabine[[decitabine co-treated with trichostatin A] affects the methylation of RASSF1 promoter] which affects the expression of RASSF1 mRNA18819746|1881974
C014347decitabinedecitabine inhibits the reaction [Cadmium Chloride results in decreased expression of RASSF1 protein]17938735
C014347decitabinedecitabine inhibits the reaction [Cadmium Chloride results in increased methylation of RASSF1 promoter]17938735
C014347decitabinedecitabine promotes the reaction [arsenic trioxide results in increased expression of RASSF1 mRNA]16613325
C014347decitabinedecitabine results in decreased methylation of RASSF1 gene19840838
C014347decitabinedecitabine results in decreased methylation of RASSF1 promoter16613325|1820329
C014347decitabine[decitabine results in decreased methylation of RASSF1 promoter] which results in increased expression of RASSF1 mRNA16613325|1661332
C014347decitabinedecitabine results in increased expression of RASSF1 mRNA16613325|1820329
C014347decitabinedecitabine results in increased expression of RASSF1 protein16613325|1820329
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RASSF1 mRNA28628672
D016264Dextran SulfateRASSF1 gene mutant form results in increased susceptibility to Dextran Sulfate24146755
D016264Dextran Sulfate[RASSF1 gene mutant form results in increased susceptibility to Dextran Sulfate] which results in decreased activity of STK4 protein24146755
D016264Dextran Sulfate[RASSF1 gene mutant form results in increased susceptibility to Dextran Sulfate] which results in increased activity of MPO protein24146755
D016264Dextran Sulfate[RASSF1 gene mutant form results in increased susceptibility to Dextran Sulfate] which results in increased expression of BAX mRNA24146755
D016264Dextran Sulfate[RASSF1 gene mutant form results in increased susceptibility to Dextran Sulfate] which results in increased expression of BAX protein24146755
D016264Dextran Sulfate[RASSF1 gene mutant form results in increased susceptibility to Dextran Sulfate] which results in increased phosphorylation of and affects the localization of YAP1 protein24146755
D016264Dextran Sulfate[RASSF1 gene mutant form results in increased susceptibility to Dextran Sulfate] which results in increased secretion of CCL2 protein24146755
D016264Dextran Sulfate[RASSF1 gene mutant form results in increased susceptibility to Dextran Sulfate] which results in increased secretion of IL6 protein24146755
D003976DiazinonDiazinon results in increased methylation of RASSF1 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RASSF1 mRNA17361019|2126653
D002945CisplatinABT-737 promotes the reaction [RASSF1 results in increased susceptibility to Cisplatin]21880625
D002945Cisplatin[Cisplatin co-treated with panobinostat] affects the expression of RASSF1 mRNA21791302
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of RASSF1 mRNA]27392435
D002945CisplatinCisplatin results in increased expression of RASSF1 mRNA27594783
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of RASSF1 mRNA]27392435
D002945CisplatinRASSF1 protein results in increased susceptibility to Cisplatin17444856
D002945CisplatinRASSF1 results in increased susceptibility to Cisplatin21880625
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of RASSF1 protein20970405
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of RASSF1 promoter20970405
D004147DioxinsDioxins affects the expression of RASSF1 mRNA20463971
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RASSF1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RASSF1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RASSF1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of RASSF1 mRNA23649840
D005047EtoposideABT-737 promotes the reaction [RASSF1 results in increased susceptibility to Etoposide]21880625
D005047Etoposide[RASSF1 co-treated with Etoposide] affects the folding of and results in increased activity of BAX protein21880625
D005047Etoposide[RASSF1 co-treated with Etoposide] results in increased cleavage of CASP3 protein21880625
D005047Etoposide[RASSF1 co-treated with Etoposide] results in increased expression of CDKN1A protein21880625
D005047EtoposideRASSF1 results in increased susceptibility to Etoposide21880625
D015025ZearalenoneZearalenone results in increased expression of RASSF1 mRNA28965971
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of RASSF1 mRNA28329830
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased methylation of RASSF1 promoter20188851
C039281furanfuran results in increased expression of RASSF1 mRNA24183702
C039281furanfuran results in decreased expression of RASSF1 mRNA24614236
C039281furanfuran results in increased methylation of RASSF1 promoter24614236
D005839GentamicinsGentamicins results in increased expression of RASSF1 mRNA22061828
C511402Grape Seed ProanthocyanidinsGrape Seed Proanthocyanidins results in increased expression of RASSF1 mRNA22749965
C511402Grape Seed ProanthocyanidinsGrape Seed Proanthocyanidins results in increased expression of RASSF1 protein22749965
D017313FenretinideFenretinide results in increased expression of RASSF1 mRNA28973697
D006851Hydrochloric AcidHydrochloric Acid results in decreased expression of RASSF1 mRNA15046208
C016517indole-3-carbinolindole-3-carbinol affects the expression of RASSF1 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RASSF1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RASSF1 mRNA28628672
D007545IsoproterenolIsoproterenol results in decreased expression of RASSF1 mRNA24945829
D007545IsoproterenolIsoproterenol results in decreased expression of RASSF1 protein24945829
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of RASSF1 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of RASSF1 mRNA]27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RASSF1 mRNA23086925
C410337K 7174K 7174 results in increased expression of RASSF1 mRNA24086573
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RASSF1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of RASSF1 mRNA26378955
D008748Methylcholanthrene[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of RASSF1 protein20970405
D008748Methylcholanthrene[Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of RASSF1 promoter20970405
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RASSF1 mRNA23458150
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RASSF1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RASSF1 mRNA23649840
D016685MitomycinRASSF1 protein results in increased susceptibility to Mitomycin17444856
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RASSF1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RASSF1 mRNA"25554681
D009532NickelNickel analog results in increased expression of RASSF1 mRNA24579805
D009532NickelNickel analog results in increased expression of RASSF1 protein24579805
C017557nickel subsulfidenickel subsulfide results in decreased expression of RASSF1 mRNA21565688
C017557nickel subsulfidenickel subsulfide results in increased methylation of RASSF1 gene21565688
D009966OrphenadrineOrphenadrine affects the expression of RASSF1 mRNA23665939
C496932panobinostat[Cisplatin co-treated with panobinostat] affects the expression of RASSF1 mRNA21791302
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of RASSF1 mRNA19095052
D010634PhenobarbitalPhenobarbital affects the expression of RASSF1 mRNA23091169
D010656PhenylephrineRASSF1 protein results in decreased susceptibility to Phenylephrine19652091
D010656PhenylephrineRASSF1 protein results in decreased susceptibility to Phenylephrine19652091
D010936Plant ExtractsPlant Extracts results in increased expression of RASSF1 mRNA23557933
D011342ProcainamideProcainamide results in increased expression of RASSF1 protein17938735
C045950propiconazolepropiconazole results in increased expression of RASSF1 mRNA21278054
D011794QuercetinQuercetin results in increased expression of RASSF1 mRNA21632981
D012643SeleniumSelenium results in increased expression of RASSF1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of RASSF1 mRNA25351596
D012906SmokeSmoke analog affects the expression of RASSF123174910
D012906SmokeSmoke analog affects the methylation of RASSF1 promoter23174910
C017947sodium arsenitesodium arsenite affects the methylation of RASSF1 gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of RASSF1 mRNA12634122
D012999SomanSoman results in increased expression of RASSF1 mRNA19281266
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RASSF1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of RASSF1 mRNA26378955
D013605T-2 ToxinT-2 Toxin results in increased expression of RASSF1 mRNA26141394
D013629TamoxifenTamoxifen affects the expression of RASSF1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RASSF1 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RASSF1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RASSF1 mRNA26290441
D013853ThioacetamideThioacetamide results in increased expression of RASSF1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of RASSF1 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of RASSF1 promoter25214829
C012589trichostatin A[decitabine co-treated with trichostatin A] affects the expression of RASSF1 protein17019711
C012589trichostatin A[[decitabine co-treated with trichostatin A] affects the methylation of RASSF1 promoter] which affects the expression of RASSF1 mRNA18819746|1881974
D014520UrethaneUrethane results in increased expression of RASSF1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of RASSF1 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RASSF1 promoter26410583
D014747VinblastineVinblastine results in increased expression of RASSF1 mRNA20624997
D014750VincristineVincristine results in increased expression of RASSF1 mRNA20624997
C017963vinyl carbamatevinyl carbamate results in decreased expression of RASSF1 mRNA17849452
D014810Vitamin EVitamin E results in increased expression of RASSF1 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of RASSF1 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18566590  20562859  21199877  23455924  
GO:0008270zinc ion binding-TAS11333291  
GO ID GO Term Qualifier Evidence PubMed
GO:0007050cell cycle arrest-IMP12024041  
GO:0007265Ras protein signal transduction-IDA15109305  
GO:0070507regulation of microtubule cytoskeleton organization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle pole-IEA-  
GO:0005634nucleus-IDA14743218  
GO:0005737cytoplasm-IEA-  
GO:0005815microtubule organizing center-IEA-  
GO:0005874microtubule-IEA-  
GO:0015630microtubule cytoskeleton-IDA14743218  
KEGG ID KEGG Term
hsa05200Pathways in cancer
hsa05219Bladder cancer
hsa05223Non-small cell lung cancer
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22217548Similar DNA methylation pattern in lung tumours from smokers and never-smokers with second-hand tobacco smoke exposure. (2012 Jul)Scesnaite AMutagenesis
18349282DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients. (2008 Mar)Feng QCancer Epidemiol Biomarkers Prev
12795841[Expression of different RASSF1 transcripts and its clinical significance in lung carcinoma]. (2003 Mar)Shao KZhonghua Zhong Liu Za Zhi
19807915Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation. (2009 Oct 6)Taioli EBMC Cancer
28421310Comparison of Selected Protein Levels in Tumour and Surgical Margin in a Group of Patients with Oral Cavity Cancer. (2017 Aug)Strzelczyk JKBiochem Genet
25754026Meta-analyses of gene methylation and smoking behavior in non-small cell lung cancer patients. (2015 Mar 10)Huang TSci Rep
20371677Long interspersed nuclear element 1 hypomethylation is a marker of poor prognosis in stage IA non-small cell lung cancer. (2010 Apr 15)Saito KClin Cancer Res
16125301Single nucleotide polymorphism at codon 133 of the RASSF1 gene is preferentially associated with human lung adenocarcinoma risk. (2006 Jul 8)Kanzaki HCancer Lett
22962272DNA methylation biomarkers offer improved diagnostic efficiency in lung cancer. (2012 Nov 15)Nikolaidis GCancer Res