Gene: PKP3

11187
-
plakophilin 3
protein-coding
11p15.5
Ensembl:ENSG00000184363 MIM:605561 Vega:OTTHUMG00000119068 UniprotKB:Q9Y446
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.482e-1 (AD)  3.879e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRHR10.704
RHOV0.703
ABCG40.698
CDH220.689
COL26A10.685
NPM20.678
MCHR10.678
TFR20.676
KCNN20.676
RELL20.674

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPM-0.451
YES1-0.441
SGMS2-0.43
HEY2-0.424
ACTL6A-0.423
REST-0.42
WWTR1-0.406
TGFB3-0.402
CNN2-0.397
RAI14-0.395

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PKP3 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of PKP3 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP3 mRNA"27188386
C0293704-toluidine4-toluidine results in increased expression of PKP3 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP3 mRNA"27188386
C006632arsenic trioxidePKP3 protein results in decreased susceptibility to arsenic trioxide20707922
C015001arsenitearsenite results in increased expression of PKP3 mRNA18191166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PKP3 mRNA19770486
C006780bisphenol Abisphenol A results in decreased methylation of PKP3 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of PKP3 mRNA25181051
D002330CarmustinePKP3 mRNA affects the susceptibility to Carmustine16365179
C018021cobaltous chloridecobaltous chloride results in increased expression of PKP3 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of PKP3 mRNA19549813
D002117CalcitriolCalcitriol results in increased expression of PKP3 mRNA26485663
C039281furanfuran results in decreased expression of PKP3 mRNA25539665
C544151jinfukangjinfukang results in increased expression of PKP3 mRNA27392435
C410337K 7174K 7174 results in decreased expression of PKP3 mRNA24086573
C568376MT19c compoundMT19c compound results in decreased expression of PKP3 mRNA21781307
D009151Mustard GasMustard Gas results in increased phosphorylation of PKP3 protein19845377
C028007nickel monoxidenickel monoxide results in increased expression of PKP3 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of PKP3 mRNA18651567
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of PKP3 mRNA23948077
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PKP3 protein26879310
C006253pirinixic acidpirinixic acid results in increased expression of PKP3 mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of PKP3 mRNA23557933
C059514resveratrolresveratrol results in decreased expression of PKP3 protein18089832
D012906SmokeSmoke results in decreased expression of PKP3 mRNA21095227
C009277sodium arsenatesodium arsenate results in decreased expression of PKP3 mRNA23922661
C047246temozolomidePKP3 mRNA affects the susceptibility to temozolomide16365179
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PKP3 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PKP3 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PKP3 mRNA17035482
D013853ThioacetamideThioacetamide results in decreased expression of PKP3 mRNA23411599
D014241TrichloroethyleneTrichloroethylene results in increased methylation of PKP3 gene27618143
D014520UrethaneUrethane results in decreased expression of PKP3 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP3 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of PKP3 mRNA23527032|2627250
D014635Valproic AcidValproic Acid results in increased methylation of PKP3 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PKP3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA bindingNOTIDA25225333  
GO:0005515protein binding-IPI25225333  
GO:0019899enzyme binding-IPI25225333  
GO:0045182translation regulator activityNOTIMP25225333  
GO:0045294alpha-catenin binding-IPI23136403  
GO:0045296cadherin binding-IBA21873635  
GO:0050839cell adhesion molecule binding-IPI20859650  
GO:0098641cadherin binding involved in cell-cell adhesion-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0002159desmosome assembly-IMP20859650  
GO:0006417regulation of translationNOTIMP25225333  
GO:0007043cell-cell junction assembly-IBA21873635  
GO:0009966regulation of signal transduction-IBA21873635  
GO:0010628positive regulation of gene expression-IMP25225333  
GO:0031424keratinization-TAS-  
GO:0070268cornification-TAS-  
GO:0072659protein localization to plasma membrane-IMP20859650  
GO:0098609cell-cell adhesion-IBA21873635  
GO:0098609cell-cell adhesion-IEA-  
GO:1902373negative regulation of mRNA catabolic process-IMP25225333  
GO ID GO Term Qualifier Evidence PubMed
GO:0001533cornified envelope-TAS-  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA20859650  
GO:0005886plasma membrane-TAS-  
GO:0005911cell-cell junction-IBA21873635  
GO:0005911cell-cell junction-TAS10374265  
GO:0005913cell-cell adherens junction-HDA25468996  
GO:0005913cell-cell adherens junction-IBA21873635  
GO:0030054cell junction-IDA-  
GO:0030057desmosome-IEA-  
GO:1990124messenger ribonucleoprotein complex-IDA25225333  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25482056Fetal lung and placental methylation is associated with in utero nicotine exposure. (2014 Nov)Chhabra DEpigenetics