Gene: NISCH

11188
I-1|IR1|IRAS|hIRAS
nischarin
protein-coding
3p21.1
Ensembl:ENSG00000010322 MIM:615507 Vega:OTTHUMG00000158571 UniprotKB:Q9Y2I1
NG_033112.1
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.949e-1 (AD)  2.837e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEURL40.965
SPTAN10.958
MMS190.957
SIN3B0.956
HTT0.951
ATG9A0.951
MAPK8IP30.951
AP2A10.951
USP200.947
ATP6V0A10.946

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.632
OR4F29-0.591
TFPI2-0.402
SH2D1A-0.378
KLRB1-0.373
RAI14-0.372
C9orf135-0.372
KCNJ15-0.36
CD48-0.358
PROK2-0.353

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00697TizanidineSmall Molecule51322-75-9Approved|InvestigationalTarget
DB08838AgmatineSmall Molecule306-60-5Experimental|InvestigationalTarget
DB09242MoxonidineSmall Molecule75438-57-2Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0513601,3-dipropyl-8-cyclopentylxanthine"1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol]"22613216
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NISCH mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NISCH mRNA"18648102
D020106AcrylamideAcrylamide results in increased expression of NISCH mRNA28959563
D000242Cyclic AMP[Naphazoline affects the activity of NISCH protein] which results in decreased abundance of Cyclic AMP12037379
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of NISCH gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NISCH mRNA19770486
C044887beta-methylcholinebeta-methylcholine affects the expression of NISCH mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of NISCH mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NISCH mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of NISCH mRNA15336504
D019256Cadmium ChlorideCadmium Chloride affects the expression of NISCH mRNA20883709
D002110CaffeineCaffeine inhibits the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol]22613216
D002994ClofibrateClofibrate results in decreased expression of NISCH mRNA23811191
D003000ClonidineClonidine binds to NISCH protein24120658
D003000ClonidineClonidine binds to NISCH protein24120658
D003000ClonidineGuanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein]24120658
D003000ClonidineClonidine binds to NISCH protein24120658
D003000ClonidineClonidine binds to NISCH protein24120658
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NISCH mRNA28628672
D020927DexmedetomidineDexmedetomidine affects the activity of NISCH7486159
D003976DiazinonDiazinon results in decreased expression of NISCH mRNA29108742
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NISCH mRNA21266533
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in decreased expression of NISCH mRNA21858171
C000944dicrotophosdicrotophos results in increased expression of NISCH mRNA28302478
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of NISCH gene23968726
D004317DoxorubicinDoxorubicin results in increased expression of NISCH mRNA25896364
C062597efaroxan[efaroxan results in decreased activity of NISCH protein] which results in decreased susceptibility to Ethanol22613216
C062597efaroxanefaroxan binds to and results in decreased activity of NISCH protein16301242
C062597efaroxanefaroxan results in decreased activity of NISCH protein11486246|2261321
D000431Ethanol"1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol]"22613216
D000431EthanolADORA2A protein affects the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol]22613216
D000431EthanolCaffeine inhibits the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol]22613216
D000431Ethanol[efaroxan results in decreased activity of NISCH protein] which results in decreased susceptibility to Ethanol22613216
D000431Ethanol[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol22613216
D005485FlutamideFlutamide results in decreased expression of NISCH mRNA24136188
C069837fullerene C60fullerene C60 results in increased expression of NISCH mRNA19167457
D005839GentamicinsGentamicins results in increased expression of NISCH mRNA22061828
D006150Guanine NucleotidesGuanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein]24120658
D006150Guanine NucleotidesGuanine Nucleotides inhibits the reaction [Naphazoline binds to NISCH protein]24120658
D006152Cyclic GMP[Naphazoline affects the activity of NISCH protein] which results in increased abundance of Cyclic GMP12037379
C492448ICG 001ICG 001 results in decreased expression of NISCH mRNA26191083
D019329IdazoxanIdazoxan binds to and results in decreased activity of NISCH protein8732285
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NISCH mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NISCH mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NISCH mRNA28628672
C005219methyl cellosolvemethyl cellosolve results in increased expression of NISCH mRNA21061450
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NISCH mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NISCH mRNA23649840
C437683motexafin gadoliniummotexafin gadolinium results in decreased expression of NISCH mRNA16357179
C043482moxonidine"1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol]"22613216
C043482moxonidineADORA2A protein affects the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol]22613216
C043482moxonidineCaffeine inhibits the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol]22613216
C043482moxonidine[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol22613216
C043482moxonidinemoxonidine binds to and results in increased activity of NISCH protein22613216
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NISCH mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NISCH mRNA"25554681|2562005
D009278NaphazolineGuanine Nucleotides inhibits the reaction [Naphazoline binds to NISCH protein]24120658
D009278NaphazolineNaphazoline binds to NISCH protein24120658
D009278NaphazolineNaphazoline affects the activity of NISCH protein12037379
D009278Naphazoline[Naphazoline affects the activity of NISCH protein] which results in decreased abundance of Cyclic AMP12037379
D009278Naphazoline[Naphazoline affects the activity of NISCH protein] which results in decreased abundance of Norepinephrine12037379
D009278Naphazoline[Naphazoline affects the activity of NISCH protein] which results in increased abundance of Cyclic GMP12037379
D009278Naphazoline[Naphazoline affects the activity of NISCH protein] which results in increased secretion of NPPA protein12037379
D009278NaphazolineNaphazoline results in increased activity of NISCH protein11180982
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of NISCH mRNA19812364
C028007nickel monoxidenickel monoxide results in increased expression of NISCH mRNA19167457
D009638Norepinephrine[Naphazoline affects the activity of NISCH protein] which results in decreased abundance of Norepinephrine12037379
C025589ochratoxin Aochratoxin A results in increased expression of NISCH mRNA23358140
D010100OxygenOxygen deficiency results in increased expression of NISCH mRNA24205000
D010634PhenobarbitalPhenobarbital affects the expression of NISCH mRNA23091169
D010705PhosgenePhosgene affects the expression of NISCH mRNA16300373
D010795Phthalic AcidsPhthalic Acids results in decreased expression of NISCH mRNA21061450
D010795Phthalic AcidsPhthalic Acids results in increased expression of NISCH mRNA21061450
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of NISCH gene23968726
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NISCH mRNA19710929
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in decreased expression of NISCH mRNA21858171
C045950propiconazolepropiconazole results in decreased expression of NISCH mRNA21278054
C032302rilmenidinerilmenidine binds to and results in increased activity of NISCH protein16595736
D012822Silicon DioxideSilicon Dioxide results in decreased expression of NISCH mRNA19073995
C017947sodium arsenitesodium arsenite results in increased expression of NISCH mRNA20883709
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NISCH mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NISCH mRNA18796159
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of NISCH mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NISCH mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NISCH mRNA25613284
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NISCH mRNA"26743178
D014635Valproic AcidValproic Acid affects the expression of NISCH mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NISCH mRNA28001369|2915479
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NISCH gene25560391
C025643vinclozolinvinclozolin affects the expression of NISCH mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of NISCH mRNA23034163
D014750VincristineVincristine results in decreased expression of NISCH mRNA23649840
D019345Zinc AcetateZinc Acetate results in decreased expression of NISCH mRNA16357179

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005178integrin binding-IEA-  
GO:0005200structural constituent of cytoskeleton-IBA21873635  
GO:0005515protein binding-IPI23386062  29568061  
GO:0019901protein kinase binding-IBA21873635  
GO:0035091phosphatidylinositol binding-IEA-  
GO:0042802identical protein binding-IPI23386062  
GO ID GO Term Qualifier Evidence PubMed
GO:0006006glucose metabolic process-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0008217regulation of blood pressure-IEA-  
GO:0016601Rac protein signal transduction-IEA-  
GO:0030036actin cytoskeleton organization-IEA-  
GO:0030336negative regulation of cell migration-IEA-  
GO:0032228regulation of synaptic transmission, GABAergic-IEA-  
GO:0048243norepinephrine secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005769early endosome-IEA-  
GO:0005829cytosol-IDA15028622  
GO:0005886plasma membrane-IDA15028622  
GO:0016020membrane-HDA19946888  
GO:0055037recycling endosome-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20592015Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR. (2010 Jul 1)Ostrow KLClin Cancer Res
23503203Cigarette smoke induces methylation of the tumor suppressor gene NISCH. (2013 Apr)Ostrow KLEpigenetics