Gene: WIF1

11197
WIF-1
WNT inhibitory factor 1
protein-coding
12q14.3
Ensembl:ENSG00000156076 MIM:605186 Vega:OTTHUMG00000168832 UniprotKB:Q9Y5W5
NC_000012.12
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.908e-1 (AD)  5.619e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC1A20.831
SLC13A50.829
SLC15A20.792
CHRDL10.787
HSD17B60.779
SFXN50.767
SLC4A40.763
SLC7A100.758
SLC1A40.747
PAMR10.747

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD48-0.411
GRAP2-0.409
DPYD-0.407
F13A1-0.396
FCGR2C-0.395
MBOAT1-0.393
CNTF-0.392
SLAMF6-0.392
GADL1-0.389
SELL-0.388

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0329042,2',3,5',6-pentachlorobiphenyl"WIF1 protein results in decreased susceptibility to 2,2',3,5',6-pentachlorobiphenyl"22534176
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WIF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of WIF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WIF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WIF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of WIF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WIF1 mRNA"27188386
D020106AcrylamideAcrylamide results in increased expression of WIF1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of WIF1 gene27153756
C006632arsenic trioxidearsenic trioxide results in decreased expression of WIF1 mRNA26705709
D001241AspirinAspirin results in increased expression of WIF1 mRNA11906190
C547126AZM551248AZM551248 results in decreased expression of WIF1 mRNA22323515
C487081belinostatbelinostat results in decreased expression of WIF1 mRNA26272509
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of WIF1 mRNA26271895
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of WIF1 protein26271895
D004958Estradiol[bisphenol A results in increased susceptibility to Estradiol] which results in increased expression of WIF1 mRNA27312807
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of WIF1 mRNA26496021
D004958EstradiolEstradiol results in decreased expression of WIF1 mRNA26945725
C006780bisphenol A[bisphenol A results in increased susceptibility to Estradiol] which results in increased expression of WIF1 mRNA27312807
C006780bisphenol Abisphenol A affects the expression of WIF1 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of WIF1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of WIF1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of WIF1 mRNA25381574
C006780bisphenol Abisphenol A results in increased expression of WIF1 protein25963729
C006780bisphenol Abisphenol A results in increased methylation of WIF1 gene28505145
C006780bisphenol ACurcumin inhibits the reaction [bisphenol A results in increased expression of WIF1 protein]25963729
D0151248-Bromo Cyclic Adenosine Monophosphate[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of WIF1 mRNA16997883
C084597chlorcyclizinechlorcyclizine results in increased expression of WIF1 mRNA21058326
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of WIF1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of WIF1 mRNA26272509
C018021cobaltous chloridecobaltous chloride results in decreased expression of WIF1 mRNA24386269
D003474CurcuminCurcumin inhibits the reaction [bisphenol A results in increased expression of WIF1 protein]25963729
D003474CurcuminCurcumin results in decreased expression of WIF1 protein25963729
C014347decitabinedecitabine affects the methylation of WIF1 promoter17384664
C014347decitabine[decitabine affects the methylation of WIF1 promoter] which affects the expression of WIF1 mRNA17384664|1738466
C014347decitabine[decitabine co-treated with trichostatin A] results in increased expression of WIF1 mRNA17923031
C014347decitabinedecitabine results in decreased methylation of WIF1 promoter21515334
C014347decitabine[decitabine results in decreased methylation of WIF1 promoter] which results in increased expression of WIF1 mRNA21515334|2151533
C014347decitabinedecitabine results in increased expression of WIF1 mRNA16367923|2151533
C014347decitabinedecitabine results in decreased expression of WIF1 mRNA27915011
C107676deguelindeguelin results in increased expression of WIF1 mRNA19861542
D003907Dexamethasone[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of WIF1 mRNA16997883
D016264Dextran Sulfate[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of WIF1 mRNA26271895
D016264Dextran Sulfate[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of WIF1 protein26271895
C016366dibenzothiophenedibenzothiophene results in increased expression of WIF1 mRNA23656968
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of WIF1 mRNA28962523
D004041Dietary FatsDietary Fats results in increased expression of WIF1 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of WIF1 mRNA28085963
D004147DioxinsDioxins affects the expression of WIF1 mRNA20463971
D004317Doxorubicin[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of WIF1 mRNA21040762
C118739entinostatentinostat results in increased expression of WIF1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WIF1 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of WIF1 mRNA17351261
D005013EthosuximideEthosuximide inhibits the reaction [APP protein modified form results in increased expression of WIF1 mRNA]26420483
D005047EtoposideWIF1 protein results in increased susceptibility to Etoposide15389810
D005419FlavonoidsFlavonoids results in increased expression of WIF1 mRNA18035473
D005557FormaldehydeFormaldehyde results in increased expression of WIF1 mRNA23649840
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of WIF1 mRNA16997883
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of WIF1 mRNA26752646
D007840LatexLatex analog results in decreased expression of WIF1 mRNA24768652
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of WIF1 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of WIF1 mRNA"26251327
D015735MifepristoneMifepristone results in increased expression of WIF1 mRNA19439560
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of WIF1 mRNA"21624382|2555468
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of WIF1 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of WIF1 mRNA19812364
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of WIF1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of WIF1 mRNA25729387
D017239PaclitaxelWIF1 protein results in increased susceptibility to Paclitaxel15389810
D000073878Palm OilPalm Oil results in increased expression of WIF1 mRNA18042831
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of WIF1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of WIF1 mRNA19482888
D010656PhenylephrinePhenylephrine results in increased expression of WIF1 mRNA18158353
D011374ProgesteronePGR protein affects the reaction [Progesterone results in decreased expression of WIF1 mRNA]17556502
D011374ProgesteroneProgesterone results in decreased expression of WIF1 mRNA17556502
C030984pyrenepyrene results in decreased expression of WIF1 mRNA23656968
D015474IsotretinoinIsotretinoin results in increased expression of WIF1 mRNA20436886
D012822Silicon DioxideSilicon Dioxide results in decreased expression of WIF1 mRNA22431001
D053260SootSoot results in decreased expression of WIF1 mRNA26551751
C001873sporidesminMIR31 mRNA affects the reaction [sporidesmin affects the expression of WIF1 mRNA]28193462
C001873sporidesminsporidesmin affects the expression of WIF1 mRNA28193462
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of WIF1 mRNA18495758
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of WIF1 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of WIF1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of WIF1 mRNA24928892
C009495titanium dioxidetitanium dioxide results in decreased expression of WIF1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of WIF1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of WIF1 mRNA25729387
C012589trichostatin A[decitabine co-treated with trichostatin A] results in increased expression of WIF1 mRNA17923031
C012589trichostatin Atrichostatin A results in increased expression of WIF1 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of WIF1 mRNA19042947
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of WIF1 mRNA15885361
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WIF1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of WIF1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of WIF1 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of WIF1 gene25560391
C025643vinclozolinvinclozolin affects the expression of WIF1 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of WIF1 mRNA18042343

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IBA21873635  
GO:0005515protein binding-IPI19188438  21743455  22986341  25416956  26342861  
GO:0017147Wnt-protein binding-NAS24431302  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-NAS10201374  
GO:0007275multicellular organism development-IEA-  
GO:0016055Wnt signaling pathway-IEA-  
GO:0030178negative regulation of Wnt signaling pathway-NAS24431302  
GO:0045600positive regulation of fat cell differentiation-IEA-  
GO:0048856anatomical structure development-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IBA21873635  
GO:0005576extracellular region-IEA-  
GO:0009986cell surface-IBA21873635  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-195721Signaling by WNTIEA
R-HSA-201681TCF dependent signaling in response to WNTIEA
R-HSA-3772470Negative regulation of TCF-dependent signaling by WNT ligand antagonistsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23686431Wif1 hypermethylation as unfavorable prognosis of non-small cell lung cancers with EGFR mutation. (2013 Jul)Lee SMMol Cells
19174556WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. (2009 Feb)Tang YMol Cancer Ther
28927526Putative biomarkers for cervical cancer: SNVs, methylation and expression profiles. (2017 Jul)Cardoso MFSMutat Res
25754026Meta-analyses of gene methylation and smoking behavior in non-small cell lung cancer patients. (2015 Mar 10)Huang TSci Rep