Gene: KLK8

11202
HNP|NP|NRPN|PRSS19|TADG14
kallikrein related peptidase 8
protein-coding
19q13.41
Ensembl:ENSG00000129455 MIM:605644 Vega:OTTHUMG00000183086 UniprotKB:O60259
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRIM64C0.62
OR4L10.616
OR11A10.611
OR4N50.602
OR9K20.594
MAS1L0.583
OR10H30.581
OR6C760.575
OR52N10.575
SPZ10.572

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NWD1-0.38
LPAR3-0.377
SLC39A12-0.377
FGFR3-0.375
PRSS35-0.374
SLC15A2-0.368
CHRDL1-0.361
GABRG1-0.36
PAPLN-0.359
CABLES1-0.354

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of KLK8 mRNA"26377693
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLK8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLK8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLK8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLK8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLK8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLK8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLK8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLK8 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of KLK8 mRNA28959563
D000447AldehydesAldehydes results in increased expression of KLK8 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KLK8 mRNA16483693
D000976AntipainAntipain results in decreased activity of KLK8 protein16800733
D001152ArsenicalsArsenicals results in increased expression of KLK8 mRNA28625800
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KLK8 mRNA21839799
C006780bisphenol Abisphenol A results in decreased expression of KLK8 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of KLK8 mRNA26079696
D002104CadmiumCadmium results in increased expression of KLK8 mRNA21120746
D002118CalciumCalcium results in increased activity of KLK8 protein16800733
D002122Calcium ChlorideCalcium Chloride results in increased activity of KLK8 protein16800733
C002101chymostatinchymostatin results in decreased activity of KLK8 protein16800733
D003471CuprizoneCuprizone results in decreased expression of KLK8 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of KLK8 mRNA23640034
D003976DiazinonDiazinon results in increased methylation of KLK8 gene22964155
D002945Cisplatin[Cisplatin co-treated with panobinostat] affects the expression of KLK8 mRNA21791302
D002945CisplatinKLK8 protein affects the susceptibility to Cisplatin16217747
D004041Dietary FatsDietary Fats results in increased expression of KLK8 mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of KLK8 mRNA15171707
D002117CalcitriolCalcitriol results in increased expression of KLK8 mRNA26485663
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of KLK8 mRNA25198161
C118739entinostatentinostat results in increased expression of KLK8 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLK8 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of KLK8 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of KLK8 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of KLK8 mRNA17942748
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of KLK8 mRNA27776689
C032854leupeptinleupeptin results in decreased activity of KLK8 protein16800733
C002385linsidominelinsidomine results in increased oxidation of KLK8 protein28086193
D008274MagnesiumMagnesium results in increased activity of KLK8 protein16800733
D015636Magnesium ChlorideMagnesium Chloride results in increased activity of KLK8 protein16800733
D008278Magnesium SulfateMagnesium Sulfate results in increased activity of KLK8 protein16800733
C042720mercuric bromidemercuric bromide results in decreased expression of KLK8 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLK8 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of KLK8 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of KLK8 mRNA"25554681
C029938nickel sulfatenickel sulfate results in decreased activity of KLK8 protein16800733
D010126OzoneOzone results in decreased expression of KLK8 mRNA12763052
D000073878Palm OilPalm Oil results in increased expression of KLK8 mRNA18042831
C496932panobinostat[Cisplatin co-treated with panobinostat] affects the expression of KLK8 mRNA21791302
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLK8 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of KLK8 mRNA26272509
C046012pentanalpentanal results in increased expression of KLK8 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLK8 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of KLK8 mRNA26272509
D011188PotassiumPotassium results in increased activity of KLK8 protein16800733
D011189Potassium ChloridePotassium Chloride results in increased activity of KLK8 protein16800733
C005556propionaldehydepropionaldehyde results in increased expression of KLK8 mRNA26079696
C009250sevofluranesevoflurane results in increased expression of KLK8 mRNA26206149
D012906SmokeSmoke results in decreased expression of KLK8 mRNA21095227
C017947sodium arsenitesodium arsenite affects the methylation of KLK8 gene28589171
D013629TamoxifenTamoxifen affects the expression of KLK8 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KLK8 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of KLK8 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLK8 mRNA17035482
C009495titanium dioxidetitanium dioxide results in decreased expression of KLK8 mRNA23557971
C012589trichostatin Atrichostatin A results in increased expression of KLK8 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of KLK8 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KLK8 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of KLK8 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KLK8 gene25560391
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of KLK8 mRNA"25198161
D015032ZincZinc results in decreased activity of KLK8 protein16800733
D019287Zinc SulfateZinc Sulfate results in decreased activity of KLK8 protein16800733

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IDA16337200  
GO:0005515protein binding-IPI17761692  19194479  24705354  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0007613memory-IBA21873635  
GO:0007613memory-ISS-  
GO:0008219cell death-ISS-  
GO:0009611response to wounding-ISS-  
GO:0031642negative regulation of myelination-ISS-  
GO:0043616keratinocyte proliferation-ISS-  
GO:0048681negative regulation of axon regeneration-ISS-  
GO:0048812neuron projection morphogenesis-IBA21873635  
GO:0048812neuron projection morphogenesis-ISS-  
GO:0050807regulation of synapse organization-ISS-  
GO:0050808synapse organization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-ISS-  
GO:0005737cytoplasm-IDA17761692  
GO:0030141secretory granule-IBA21873635  
GO:0097180serine protease inhibitor complex-IDA17761692  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18316555A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma. (2008 Mar 1)Planque CClin Cancer Res