Gene: CHM

1121
DXS540|GGTA|HSD-32|REP-1|TCD
CHM, Rab escort protein 1
protein-coding
Xq21.2
Ensembl:ENSG00000188419 MIM:300390 Vega:OTTHUMG00000021937 UniprotKB:P24386
NG_009874.2
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LMBR10.961
SEC23A0.954
TRUB10.953
DMXL20.953
WDR120.953
MTMR70.952
SLC4A100.95
SYNJ10.949
NCKAP10.949
G3BP20.948

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.532
ROM1-0.474
RAB13-0.47
HEY2-0.459
MYL3-0.454
FLT3LG-0.451
S100A1-0.448
COPZ2-0.435
EMP3-0.43
RNF135-0.429

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CHM mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHM mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CHM mRNA26690555
D020106AcrylamideAcrylamide results in increased expression of CHM mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CHM gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CHM mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHM mRNA16483693
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of CHM mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CHM mRNA15034205
C044887beta-methylcholinebeta-methylcholine affects the expression of CHM mRNA21179406
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of CHM mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of CHM mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased phosphorylation of CHM protein22174045
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CHM protein12629582
D003010ClorgylineClorgyline results in increased expression of CHM mRNA19691856
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of CHM mRNA20971185
D003471CuprizoneCuprizone results in decreased expression of CHM mRNA26577399
D003703DemecolcineDemecolcine results in increased expression of CHM mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CHM mRNA21266533
D004147DioxinsDioxins affects the expression of CHM mRNA20463971
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CHM mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of CHM mRNA23649840
C039281furanfuran results in decreased expression of CHM mRNA25539665
D005839GentamicinsGentamicins results in increased expression of CHM protein mutant form18809619
C544151jinfukangjinfukang results in decreased expression of CHM mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CHM mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CHM mRNA23649840
D009532NickelNickel results in increased expression of CHM mRNA24768652|2558310
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of CHM mRNA20971185
D010303ParomomycinParomomycin results in increased expression of CHM protein mutant form18809619
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CHM mRNA27153767
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHM mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CHM mRNA26272509
D012834SilverSilver results in decreased expression of CHM mRNA27131904
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of CHM mRNA26496021
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of CHM mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CHM mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CHM mRNA15034205
D014050TolueneCHM gene polymorphism affects the susceptibility to Toluene28013218
C012589trichostatin Atrichostatin A results in increased expression of CHM mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHM mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of CHM mRNA23179753|2627250
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CHM gene25560391
D014750VincristineVincristine results in increased expression of CHM mRNA23649840
C111237vorinostatvorinostat results in increased expression of CHM mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004663Rab geranylgeranyltransferase activity-TAS8380507  
GO:0005092GDP-dissociation inhibitor activity-IEA-  
GO:0005096GTPase activator activity-IEA-  
GO:0017137Rab GTPase binding-IDA7957092  
GO:0017137Rab GTPase binding-IPI7957092  
GO ID GO Term Qualifier Evidence PubMed
GO:0006612protein targeting to membrane-IMP7957092  
GO:0007264small GTPase mediated signal transduction-IEA-  
GO:0007601visual perception-IEA-  
GO:0018344protein geranylgeranylation-IDA7957092  
GO:0042981regulation of apoptotic process-TAS-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IMP7957092  
GO:0005829cytosol-TAS-  
GO:0005968Rab-protein geranylgeranyltransferase complex-IDA7957092  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5633008TP53 Regulates Transcription of Cell Death GenesTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6803205TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertainTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8873719RAB geranylgeranylationTAS
R-HSA-8876198RAB GEFs exchange GTP for GDP on RABsTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24401931Association of cardiovascular risk factors with disease severity in cerebral cavernous malformation type 1 subjects with the common Hispanic mutation. (2014)Choquet HCerebrovasc Dis
12487923[Effect of traditional Chinese medicine on expression of extracellular signal-regulating kinase-1 and mitogen activated protein kinase phosphatase-1 in brain and liver of fetal rats with fetal growth restriction]. (2002 Nov)Wu YZhonghua Fu Chan Ke Za Zhi
27513070Cardiovascular Health Status by Occupational Group - 21 States, 2013. (2016 Aug 12)Shockey TMMMWR Morb Mortal Wkly Rep