Gene: AKAP13

11214
AKAP-13|AKAP-Lbc|ARHGEF13|BRX|HA-3|Ht31|LBC|PRKA13|PROTO-LB|PROTO-LBC|c-lbc|p47
A-kinase anchoring protein 13
protein-coding
15q25.3
Ensembl:ENSG00000170776 MIM:604686 Vega:OTTHUMG00000172205 UniprotKB:Q12802
NC_000015.10
PubMed|SNP Mapped
3   ANCO-SNPs
ND|AD
2   
6.474e-2 (AD)  3.990e-1 (ND)   (Frontal_Cortex)
2.890e-1 (AD)  6.340e-3 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11858860chr15:85408215 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs13379803chr15:85405478 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs16977810chr15:85395420 (GRCh38.p7)C>A / C>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20726664chr15:86168936AKAP135.100e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DCP1A0.839
DCAF50.833
LRCH10.832
RCOR10.831
EDEM10.831
ADCY30.831
ZNF5500.83
GAPVD10.828
NUP1530.828
HEATR10.827

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.422
OR4F29-0.386
KLRC2-0.364
DIAPH3-0.336
KLRC3-0.33
PDE11A-0.318
S100A1-0.302
REN-0.301
HES5-0.299
APOA1-0.297

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C02017516 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione"16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased expression of AKAP13 mRNA"20519331
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of AKAP13 mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of AKAP13 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl affects the expression of AKAP13 mRNA"20638727
D000082AcetaminophenAcetaminophen affects the expression of AKAP13 mRNA25458485
D000082AcetaminophenAcetaminophen affects the expression of AKAP13 mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of AKAP13 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of AKAP13 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of AKAP13 mRNA20458559
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of AKAP13 mRNA26377693
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AKAP13 mRNA"19150397|2001819
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of AKAP13 mRNA]24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of AKAP13 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of AKAP13 mRNA19167446|2475840
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of AKAP13 mRNA25270620
C044887beta-methylcholinebeta-methylcholine affects the expression of AKAP13 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of AKAP13 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of AKAP13 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of AKAP13 gene28505145
D002166CamptothecinAKAP13 mRNA results in decreased susceptibility to Camptothecin25269479
C018021cobaltous chloridecobaltous chloride results in increased expression of AKAP13 mRNA21139344
D005576ColforsinAKAP13 protein modified form affects the reaction [Colforsin affects the localization of ADRA2C protein]24701590
D005576ColforsinAKAP13 protein modified form affects the reaction [Colforsin results in increased expression of ADRA2C mRNA]24701590
D005576ColforsinAKAP13 protein modified form inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]24701590
D019327Copper SulfateCopper Sulfate results in increased expression of AKAP13 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of AKAP13 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of AKAP13 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of AKAP13 mRNA25562108
C093628cyproconazolecyproconazole results in decreased expression of AKAP13 mRNA22334560
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of AKAP13 mRNA"25908611
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of AKAP13 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of AKAP13 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of AKAP13 mRNA19561079
C000944dicrotophosdicrotophos results in increased expression of AKAP13 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of AKAP13 mRNA26924002
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of AKAP13 protein23301498
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of AKAP13 mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AKAP13 mRNA22079256
C109476epoxiconazoleepoxiconazole results in decreased expression of AKAP13 mRNA22334560
C024565ethylene dichlorideethylene dichloride results in decreased expression of AKAP13 mRNA28189721
C082360fipronilfipronil results in decreased expression of AKAP13 mRNA23962444
D005839GentamicinsGentamicins results in increased expression of AKAP13 mRNA22061828
D006046Gold[Gold co-treated with Polyethylene Glycols] results in increased expression of AKAP13 mRNA19695318
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AKAP13 mRNA25613284
D007501IronIron deficiency results in decreased expression of AKAP13 mRNA16629162
D007545IsoproterenolIsoproterenol results in increased expression of AKAP13 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of AKAP13 mRNA24796395
D008694MethamphetamineMethamphetamine results in increased expression of AKAP13 mRNA26307267
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to AKAP13 promoter]20348232
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of AKAP13 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of AKAP13 mRNA26272509
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of AKAP13 mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of AKAP13 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AKAP13 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of AKAP13 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of AKAP13 mRNA25729387
D010634PhenobarbitalPhenobarbital results in decreased expression of AKAP13 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AKAP13 mRNA19710929
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in increased expression of AKAP13 mRNA19695318
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AKAP13 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of AKAP13 mRNA22079256|2271453
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of AKAP13 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of AKAP13 mRNA20864642
C045950propiconazolepropiconazole results in decreased expression of AKAP13 mRNA22334560
D011441PropylthiouracilPropylthiouracil results in increased expression of AKAP13 mRNA24780913
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of AKAP13 mRNA19244175
C078903seocalcitolseocalcitol results in increased expression of AKAP13 mRNA12040012
C017947sodium arsenitesodium arsenite results in decreased expression of AKAP13 mRNA28595984
C004648testosterone enanthatetestosterone enanthate affects the expression of AKAP13 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AKAP13 mRNA21296121
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AKAP13 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of AKAP13 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of AKAP13 mRNA25729387
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of AKAP13 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of AKAP13 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of AKAP13 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of AKAP13 gene29154799
C025643vinclozolinvinclozolin affects the expression of AKAP13 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of AKAP13 mRNA23034163
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of AKAP13 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of AKAP13 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of AKAP13 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004691cAMP-dependent protein kinase activity-IEA-  
GO:0005078MAP-kinase scaffold activity-IDA21224381  
GO:0005085guanyl-nucleotide exchange factor activity-TAS-  
GO:0005089Rho guanyl-nucleotide exchange factor activity-IDA11546812  25186459  
GO:0005089Rho guanyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI9627117  15324660  15691829  16301118  17353931  21224381  
GO:0017048Rho GTPase binding-IPI25186459  
GO:0032947protein-containing complex scaffold activity-IDA23090968  
GO:0046872metal ion binding-IEA-  
GO:0051018protein kinase A binding-IDA11546812  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-IDA11546812  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007507heart development-ISS-  
GO:0010611regulation of cardiac muscle hypertrophy-IEA-  
GO:0035025positive regulation of Rho protein signal transduction-IDA11546812  
GO:0035025positive regulation of Rho protein signal transduction-IMP21224381  
GO:0043065positive regulation of apoptotic process-TAS-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IMP23090968  
GO:0043406positive regulation of MAP kinase activity-IEA-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO:0051168nuclear export-IEA-  
GO:0055007cardiac muscle cell differentiation-ISS-  
GO:0060297regulation of sarcomere organization-ISS-  
GO:0060348bone development-ISS-  
GO:0071875adrenergic receptor signaling pathway-IMP21224381  23090968  
GO:0086023adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process-ISS-  
GO:1900169regulation of glucocorticoid mediated signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005829cytosol-IDA11546812  
GO:0005829cytosol-TAS-  
GO:0005884actin filament-IEA-  
GO:0005938cell cortex-IDA11546812  
GO:0016020membrane-HDA19946888  
GO:0030864cortical actin cytoskeletoncolocalizes_withIDA11546812  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-193648NRAGE signals death through JNKTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-204998Cell death signalling via NRAGE, NRIF and NADETAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-73887Death Receptor SignallingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17068819Discovery of deregulation of zinc homeostasis and its associated genes in esophageal squamous cell carcinoma using cDNA microarray. (2007 Jan 15)Kumar AInt J Cancer
29066090Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. (2017 Nov)Allen RJLancet Respir Med