Gene: AKAP10

11216
AKAP-10|D-AKAP-2|D-AKAP2|PRKA10
A-kinase anchoring protein 10
protein-coding
17p11.2
Ensembl:ENSG00000108599 MIM:604694 Vega:OTTHUMG00000059515 UniprotKB:O43572
NG_011493.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.684e-1 (AD)  2.833e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZC3H140.92
DNAJC130.92
KRIT10.917
TMEM2450.912
COG50.909
PHF200.908
SEC24B0.908
ANKRD170.907
EXOC20.905
LONP20.905

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.578
OR4F29-0.546
KLRB1-0.335
MTRNR2L6-0.306
MTRNR2L10-0.285
NANOGNB-0.281
TBX21-0.279
KLRK1-0.275
MS4A1-0.274
HMX1-0.268

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AKAP10 mRNA"25510870
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of AKAP10 mRNA"18343893
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AKAP10 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AKAP10 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AKAP10 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AKAP10 mRNA"25510870
C0299552-nitrotoluene2-nitrotoluene results in decreased expression of AKAP10 mRNA15612046
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKAP10 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKAP10 mRNA"27188386
C496492abrineabrine results in decreased expression of AKAP10 mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of AKAP10 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of AKAP10 mRNA22230336
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of AKAP10 mRNA21298039
D001280AtrazineAtrazine results in increased expression of AKAP10 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AKAP10 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AKAP10 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of AKAP10 mRNA20068009
C006780bisphenol Abisphenol A results in increased expression of AKAP10 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AKAP10 mRNA28628672
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of AKAP10 mRNA23650126
D003703DemecolcineDemecolcine results in increased expression of AKAP10 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AKAP10 mRNA28628672
C000944dicrotophosdicrotophos results in decreased expression of AKAP10 mRNA28302478
C024629dimethyl phthalatedimethyl phthalate affects the expression of AKAP10 mRNA26924002
D005557FormaldehydeFormaldehyde results in decreased expression of AKAP10 mRNA20655997
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AKAP10 mRNA28628672
C051890irinotecanirinotecan metabolite results in decreased expression of AKAP10 mRNA15956246
C051890irinotecanirinotecan results in decreased expression of AKAP10 mRNA15956246
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AKAP10 mRNA28628672
D007854LeadLead affects the expression of AKAP10 mRNA28903495
C045463leflunomideleflunomide results in increased expression of AKAP10 mRNA28988120
C036868methyl carbamatemethyl carbamate results in decreased expression of AKAP10 mRNA15612046
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of AKAP10 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of AKAP10 mRNA"25554681
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AKAP10 mRNA"25510870
D010615PhenacetinPhenacetin results in increased expression of AKAP10 mRNA17082564
C030299phenylhydrazinephenylhydrazine results in increased expression of AKAP10 mRNA17082564
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKAP10 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of AKAP10 mRNA26272509
D010672PhenytoinPhenytoin results in increased expression of AKAP10 mRNA20345932
D010936Plant ExtractsPlant Extracts results in increased expression of AKAP10 mRNA23557933
C009277sodium arsenatesodium arsenate results in increased expression of AKAP10 mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AKAP10 mRNA18343893|2157046
C012589trichostatin Atrichostatin A results in increased expression of AKAP10 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of AKAP10 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of AKAP10 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of AKAP10 mRNA26705709
D001335Vehicle EmissionsVehicle Emissions affects the methylation of AKAP10 gene25560391
D014750VincristineVincristine results in increased expression of AKAP10 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20159461  
GO:0051018protein kinase A binding-IPI25097019  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS9326583  
GO:0007596blood coagulation-TAS-  
GO:0008104protein localization-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA-  
GO:0032991protein-containing complex-IDA25097019  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21701445Possible counter effect in newborns of 1936A>G (I646V) polymorphism in the AKAP10 gene encoding A-kinase-anchoring protein 10. (2012 Mar)Loniewska BJ Perinatol